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Crystal structure of the mouse p53 core domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006915	biological_process	apoptotic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 3001

Chain	Residue
A	CYS1173
A	HIS1176
A	CYS1235
A	CYS1239

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Functional Information from PROSITE/UniProt

site_id	PS00348
Number of Residues	13
Details	P53 p53 family signature. MCNSSCMGGMNRR

Chain	Residue	Details
A	MET1234-ARG1246

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	190
Details	DNA_BIND: DNA_BIND => ECO:0000250|UniProtKB:P04637

Chain	Residue	Details
A	THR1099-LYS1289

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:16717092

Chain	Residue	Details
A	CYS1173
A	HIS1176
A	CYS1235
A	CYS1239

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Interaction with DNA => ECO:0000269|PubMed:16717092

Chain	Residue	Details
A	LYS1117

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P04637

Chain	Residue	Details
A	LYS1117

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site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine; by AURKB => ECO:0000250|UniProtKB:P04637

Chain	Residue	Details
A	SER1180
A	SER1266

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site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by AURKB => ECO:0000250|UniProtKB:P04637

Chain	Residue	Details
A	THR1281

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site_id	SWS_FT_FI7
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P04637

Chain	Residue	Details
A	LYS1288
A	LYS1289

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