2IMW

Mechanism of Template-Independent Nucleotide Incorporation Catalyzed by a Template-Dependent DNA Polymerase

Functional Information from GO Data

Chain	GOid	namespace	contents
P	0000287	molecular_function	magnesium ion binding
P	0003677	molecular_function	DNA binding
P	0003684	molecular_function	damaged DNA binding
P	0003887	molecular_function	DNA-directed DNA polymerase activity
P	0005737	cellular_component	cytoplasm
P	0006260	biological_process	DNA replication
P	0006261	biological_process	DNA-templated DNA replication
P	0006281	biological_process	DNA repair
P	0006974	biological_process	DNA damage response
P	0016740	molecular_function	transferase activity
P	0016779	molecular_function	nucleotidyltransferase activity
P	0034061	molecular_function	DNA polymerase activity
P	0042276	biological_process	error-prone translesion synthesis
P	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA P 406

Chain	Residue
P	ASP7
P	PHE8
P	ASP105
P	DDS401
P	HOH660

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA P 407

Chain	Residue
T	HOH50
T	HOH193
P	ALA181
P	ILE186
P	HOH663
P	HOH669

---

site_id	AC3
Number of Residues	22
Details	BINDING SITE FOR RESIDUE DDS P 401

Chain	Residue
P	ASP7
P	PHE8
P	ASP9
P	TYR10
P	PHE11
P	ALA44
P	THR45
P	TYR48
P	ARG51
P	ASP105
P	LYS159
P	CA406
P	HOH508
P	HOH509
P	HOH513
P	HOH613
P	HOH660
P	HOH665
P	HOH670
P	HOH672
S	DG1801
T	DC1918

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO P 501

Chain	Residue
P	GLU100
P	LYS148
P	ARG240
S	HOH206

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO P 502

Chain	Residue
P	LYS78
P	ARG247
S	DG1802

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO P 503

Chain	Residue
P	ALA220
P	TYR224

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO P 504

Chain	Residue
P	HIS285
P	VAL287
P	SER297
P	ARG336
P	LYS348

---

site_id	AC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO P 505

Chain	Residue
P	TYR122

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO P 506

Chain	Residue
P	VAL249
P	ARG267
P	GLU271

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	184
Details	Domain: {"description":"UmuC"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Substrate discrimination"}

Chain

Residue

Details

---