2IJ5
Crystal structure of cytochrome P450 CYP121, P212121 space group
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0009975 | molecular_function | cyclase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| A | 0016717 | molecular_function | oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water |
| A | 0020037 | molecular_function | heme binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070025 | molecular_function | carbon monoxide binding |
| B | 0004497 | molecular_function | monooxygenase activity |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0009975 | molecular_function | cyclase activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| B | 0016717 | molecular_function | oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water |
| B | 0020037 | molecular_function | heme binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070025 | molecular_function | carbon monoxide binding |
| C | 0004497 | molecular_function | monooxygenase activity |
| C | 0005506 | molecular_function | iron ion binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0009975 | molecular_function | cyclase activity |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| C | 0016717 | molecular_function | oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water |
| C | 0020037 | molecular_function | heme binding |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0070025 | molecular_function | carbon monoxide binding |
| D | 0004497 | molecular_function | monooxygenase activity |
| D | 0005506 | molecular_function | iron ion binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0009975 | molecular_function | cyclase activity |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| D | 0016717 | molecular_function | oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water |
| D | 0020037 | molecular_function | heme binding |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0070025 | molecular_function | carbon monoxide binding |
| E | 0004497 | molecular_function | monooxygenase activity |
| E | 0005506 | molecular_function | iron ion binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0009975 | molecular_function | cyclase activity |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| E | 0016717 | molecular_function | oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water |
| E | 0020037 | molecular_function | heme binding |
| E | 0046872 | molecular_function | metal ion binding |
| E | 0070025 | molecular_function | carbon monoxide binding |
| F | 0004497 | molecular_function | monooxygenase activity |
| F | 0005506 | molecular_function | iron ion binding |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0009975 | molecular_function | cyclase activity |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| F | 0016717 | molecular_function | oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water |
| F | 0020037 | molecular_function | heme binding |
| F | 0046872 | molecular_function | metal ion binding |
| F | 0070025 | molecular_function | carbon monoxide binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2820 |
| Chain | Residue |
| A | SER61 |
| A | MET62 |
| A | LYS63 |
| A | GLN342 |
| A | HIS343 |
| A | HOH3103 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 2821 |
| Chain | Residue |
| B | ASN84 |
| B | GLN342 |
| B | HIS343 |
| B | SER61 |
| B | MET62 |
| B | LYS63 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 C 2822 |
| Chain | Residue |
| C | ARG58 |
| C | SER61 |
| C | MET62 |
| C | LYS63 |
| C | GLN342 |
| C | HIS343 |
| C | HOH2961 |
| C | HOH3171 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 D 2823 |
| Chain | Residue |
| D | ARG58 |
| D | SER61 |
| D | MET62 |
| D | LYS63 |
| D | HIS343 |
| D | HOH2873 |
| D | HOH3027 |
| D | HOH3065 |
| D | HOH3200 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 E 2824 |
| Chain | Residue |
| D | ARG28 |
| E | ARG58 |
| E | SER61 |
| E | MET62 |
| E | LYS63 |
| E | HIS343 |
| E | HOH2873 |
| E | HOH2905 |
| E | HOH3221 |
| E | HOH3233 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 F 2825 |
| Chain | Residue |
| F | ARG58 |
| F | SER61 |
| F | MET62 |
| F | LYS63 |
| F | HIS343 |
| F | HOH2989 |
| F | HOH3001 |
| F | HOH3158 |
| site_id | AC7 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE HEM A 462 |
| Chain | Residue |
| A | MET62 |
| A | MET86 |
| A | HIS146 |
| A | PHE230 |
| A | GLY234 |
| A | SER237 |
| A | THR238 |
| A | PHE241 |
| A | PHE280 |
| A | LEU284 |
| A | ARG286 |
| A | ALA337 |
| A | PHE338 |
| A | GLY339 |
| A | HIS343 |
| A | CYS345 |
| A | PRO346 |
| A | HOH2861 |
| A | HOH2886 |
| A | HOH2888 |
| A | HOH2928 |
| A | HOH2975 |
| A | HOH2991 |
| site_id | AC8 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE HEM B 462 |
| Chain | Residue |
| B | MET62 |
| B | MET86 |
| B | HIS146 |
| B | PHE230 |
| B | GLY234 |
| B | SER237 |
| B | THR238 |
| B | PHE241 |
| B | PHE280 |
| B | LEU284 |
| B | ARG286 |
| B | ALA337 |
| B | PHE338 |
| B | GLY339 |
| B | HIS343 |
| B | CYS345 |
| B | PRO346 |
| B | HOH2845 |
| B | HOH2853 |
| B | HOH2928 |
| B | HOH2955 |
| B | HOH3010 |
| B | HOH3025 |
| site_id | AC9 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE HEM C 462 |
| Chain | Residue |
| C | THR238 |
| C | PHE241 |
| C | PHE280 |
| C | LEU284 |
| C | ARG286 |
| C | ALA337 |
| C | PHE338 |
| C | GLY339 |
| C | HIS343 |
| C | CYS345 |
| C | PRO346 |
| C | HOH2828 |
| C | HOH2840 |
| C | HOH2882 |
| C | HOH2916 |
| C | HOH2919 |
| C | HOH3015 |
| C | MET62 |
| C | MET86 |
| C | HIS146 |
| C | PHE230 |
| C | GLY234 |
| C | SER237 |
| site_id | BC1 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE HEM D 462 |
| Chain | Residue |
| D | MET62 |
| D | MET86 |
| D | HIS146 |
| D | ALA233 |
| D | GLY234 |
| D | SER237 |
| D | PHE241 |
| D | PHE280 |
| D | LEU284 |
| D | ARG286 |
| D | ALA337 |
| D | PHE338 |
| D | GLY339 |
| D | HIS343 |
| D | CYS345 |
| D | PRO346 |
| D | GLY347 |
| D | HOH2837 |
| D | HOH2851 |
| D | HOH2863 |
| D | HOH2971 |
| D | HOH3000 |
| D | HOH3037 |
| site_id | BC2 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE HEM E 462 |
| Chain | Residue |
| E | MET62 |
| E | MET86 |
| E | HIS146 |
| E | PHE230 |
| E | GLY234 |
| E | SER237 |
| E | PHE241 |
| E | PHE280 |
| E | LEU284 |
| E | ARG286 |
| E | ALA337 |
| E | PHE338 |
| E | GLY339 |
| E | HIS343 |
| E | CYS345 |
| E | PRO346 |
| E | HOH2862 |
| E | HOH2881 |
| E | HOH2935 |
| E | HOH3017 |
| E | HOH3031 |
| E | HOH3265 |
| E | HOH3277 |
| site_id | BC3 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE HEM F 462 |
| Chain | Residue |
| F | MET62 |
| F | MET86 |
| F | HIS146 |
| F | PHE230 |
| F | GLY234 |
| F | SER237 |
| F | THR238 |
| F | PHE280 |
| F | LEU284 |
| F | ARG286 |
| F | ALA337 |
| F | PHE338 |
| F | GLY339 |
| F | HIS343 |
| F | CYS345 |
| F | PRO346 |
| F | HOH2840 |
| F | HOH2927 |
| F | HOH2977 |
| F | HOH3039 |
| F | HOH3045 |
| F | HOH3059 |
Functional Information from PROSITE/UniProt
| site_id | PS00086 |
| Number of Residues | 10 |
| Details | CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGrGQHFCPG |
| Chain | Residue | Details |
| A | PHE338-GLY347 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17028183","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19416919","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12435731","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17028183","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18818197","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19416919","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22890978","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23620594","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Binding site: {"description":"axial binding residue"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 12 |
| Details | Site: {"description":"Participates in a stacking interactions with the tyrosyl of cYY"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | Site: {"description":"Important for the position of heme"} |
| Chain | Residue | Details |
