Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2IIR

Acetate kinase from a hypothermophile Thermotoga maritima

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006082	biological_process	organic acid metabolic process
A	0006083	biological_process	acetate metabolic process
A	0006085	biological_process	acetyl-CoA biosynthetic process
A	0008776	molecular_function	acetate kinase activity
A	0016301	molecular_function	kinase activity
A	0016310	biological_process	phosphorylation
A	0016774	molecular_function	phosphotransferase activity, carboxyl group as acceptor
A	0046872	molecular_function	metal ion binding
B	0000287	molecular_function	magnesium ion binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0006082	biological_process	organic acid metabolic process
B	0006083	biological_process	acetate metabolic process
B	0006085	biological_process	acetyl-CoA biosynthetic process
B	0008776	molecular_function	acetate kinase activity
B	0016301	molecular_function	kinase activity
B	0016310	biological_process	phosphorylation
B	0016774	molecular_function	phosphotransferase activity, carboxyl group as acceptor
B	0046872	molecular_function	metal ion binding
C	0000287	molecular_function	magnesium ion binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0006082	biological_process	organic acid metabolic process
C	0006083	biological_process	acetate metabolic process
C	0006085	biological_process	acetyl-CoA biosynthetic process
C	0008776	molecular_function	acetate kinase activity
C	0016301	molecular_function	kinase activity
C	0016310	biological_process	phosphorylation
C	0016774	molecular_function	phosphotransferase activity, carboxyl group as acceptor
C	0046872	molecular_function	metal ion binding
D	0000287	molecular_function	magnesium ion binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0006082	biological_process	organic acid metabolic process
D	0006083	biological_process	acetate metabolic process
D	0006085	biological_process	acetyl-CoA biosynthetic process
D	0008776	molecular_function	acetate kinase activity
D	0016301	molecular_function	kinase activity
D	0016310	biological_process	phosphorylation
D	0016774	molecular_function	phosphotransferase activity, carboxyl group as acceptor
D	0046872	molecular_function	metal ion binding
E	0000287	molecular_function	magnesium ion binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0006082	biological_process	organic acid metabolic process
E	0006083	biological_process	acetate metabolic process
E	0006085	biological_process	acetyl-CoA biosynthetic process
E	0008776	molecular_function	acetate kinase activity
E	0016301	molecular_function	kinase activity
E	0016310	biological_process	phosphorylation
E	0016774	molecular_function	phosphotransferase activity, carboxyl group as acceptor
E	0046872	molecular_function	metal ion binding
F	0000287	molecular_function	magnesium ion binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0006082	biological_process	organic acid metabolic process
F	0006083	biological_process	acetate metabolic process
F	0006085	biological_process	acetyl-CoA biosynthetic process
F	0008776	molecular_function	acetate kinase activity
F	0016301	molecular_function	kinase activity
F	0016310	biological_process	phosphorylation
F	0016774	molecular_function	phosphotransferase activity, carboxyl group as acceptor
F	0046872	molecular_function	metal ion binding
G	0000287	molecular_function	magnesium ion binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0006082	biological_process	organic acid metabolic process
G	0006083	biological_process	acetate metabolic process
G	0006085	biological_process	acetyl-CoA biosynthetic process
G	0008776	molecular_function	acetate kinase activity
G	0016301	molecular_function	kinase activity
G	0016310	biological_process	phosphorylation
G	0016774	molecular_function	phosphotransferase activity, carboxyl group as acceptor
G	0046872	molecular_function	metal ion binding
H	0000287	molecular_function	magnesium ion binding
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0006082	biological_process	organic acid metabolic process
H	0006083	biological_process	acetate metabolic process
H	0006085	biological_process	acetyl-CoA biosynthetic process
H	0008776	molecular_function	acetate kinase activity
H	0016301	molecular_function	kinase activity
H	0016310	biological_process	phosphorylation
H	0016774	molecular_function	phosphotransferase activity, carboxyl group as acceptor
H	0046872	molecular_function	metal ion binding
I	0000287	molecular_function	magnesium ion binding
I	0005524	molecular_function	ATP binding
I	0005737	cellular_component	cytoplasm
I	0006082	biological_process	organic acid metabolic process
I	0006083	biological_process	acetate metabolic process
I	0006085	biological_process	acetyl-CoA biosynthetic process
I	0008776	molecular_function	acetate kinase activity
I	0016301	molecular_function	kinase activity
I	0016310	biological_process	phosphorylation
I	0016774	molecular_function	phosphotransferase activity, carboxyl group as acceptor
I	0046872	molecular_function	metal ion binding
J	0000287	molecular_function	magnesium ion binding
J	0005524	molecular_function	ATP binding
J	0005737	cellular_component	cytoplasm
J	0006082	biological_process	organic acid metabolic process
J	0006083	biological_process	acetate metabolic process
J	0006085	biological_process	acetyl-CoA biosynthetic process
J	0008776	molecular_function	acetate kinase activity
J	0016301	molecular_function	kinase activity
J	0016310	biological_process	phosphorylation
J	0016774	molecular_function	phosphotransferase activity, carboxyl group as acceptor
J	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS01075
Number of Residues	12
Details	ACETATE_KINASE_1 Acetate and butyrate kinases family signature 1. VLvINsGSSSiK

Chain	Residue	Details
A	VAL3-LYS14

site_id	PS01076
Number of Residues	18
Details	ACETATE_KINASE_2 Acetate and butyrate kinases family signature 2. IItcHiGnGaSVaAvkyG

Chain	Residue	Details
A	ILE203-GLY220

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255\|HAMAP-Rule:MF_00020

Chain	Residue	Details
A	ASP147
B	ASP147
C	ASP147
D	ASP147
E	ASP147
F	ASP147
G	ASP147
H	ASP147
I	ASP147
J	ASP147

site_id	SWS_FT_FI2
Number of Residues	70
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00020

Chain	Residue	Details
B	HIS207
B	ASP283
B	GLY331
B	GLU386
C	ASN7
C	LYS14
C	ARG90
C	HIS207
C	ASP283
C	GLY331
C	GLU386
D	ASN7
D	LYS14
D	ARG90
D	HIS207
D	ASP283
D	GLY331
D	GLU386
E	ASN7
E	LYS14
E	ARG90
E	HIS207
E	ASP283
E	GLY331
E	GLU386
F	ASN7
F	LYS14
F	ARG90
F	HIS207
F	ASP283
F	GLY331
F	GLU386
G	ASN7
G	LYS14
G	ARG90
G	HIS207
G	ASP283
G	GLY331
G	GLU386
H	ASN7
H	LYS14
H	ARG90
H	HIS207
H	ASP283
H	GLY331
H	GLU386
I	ASN7
I	LYS14
I	ARG90
I	HIS207
I	ASP283
I	GLY331
I	GLU386
J	ASN7
J	LYS14
J	ARG90
J	HIS207
J	ASP283
J	GLY331
J	GLU386
A	ASN7
A	LYS14
A	ARG90
A	HIS207
A	ASP283
A	GLY331
A	GLU386
B	ASN7
B	LYS14
B	ARG90

site_id	SWS_FT_FI3
Number of Residues	20
Details	SITE: Transition state stabilizer => ECO:0000255\|HAMAP-Rule:MF_00020

Chain	Residue	Details
A	HIS179
A	ARG240
B	HIS179
B	ARG240
C	HIS179
C	ARG240
D	HIS179
D	ARG240
E	HIS179
E	ARG240
F	HIS179
F	ARG240
G	HIS179
G	ARG240
H	HIS179
H	ARG240
I	HIS179
I	ARG240
J	HIS179
J	ARG240

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)