2III

Crystal structure of the adenosylmethionine decarboxylase (aq_254) from aquifex aeolicus vf5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004014	molecular_function	adenosylmethionine decarboxylase activity
A	0005829	cellular_component	cytosol
A	0006596	biological_process	polyamine biosynthetic process
A	0008295	biological_process	spermidine biosynthetic process
A	0016829	molecular_function	lyase activity
A	0016831	molecular_function	carboxy-lyase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 136

Chain	Residue
A	ASP19
A	ASP22
A	ASP26
A	HOH181
A	HOH226

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 137

Chain	Residue
A	GLU32
A	LYS42
A	SER45
A	TYR47

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Schiff-base intermediate with substrate; via pyruvic acid","evidences":[{"source":"HAMAP-Rule","id":"MF_00464","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton acceptor; for processing activity","evidences":[{"source":"HAMAP-Rule","id":"MF_00464","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"Proton donor; for catalytic activity","evidences":[{"source":"HAMAP-Rule","id":"MF_00464","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Cleavage (non-hydrolytic); by autolysis","evidences":[{"source":"HAMAP-Rule","id":"MF_00464","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Pyruvic acid (Ser); by autocatalysis","evidences":[{"source":"HAMAP-Rule","id":"MF_00464","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---