2III

Crystal structure of the adenosylmethionine decarboxylase (aq_254) from aquifex aeolicus vf5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004014	molecular_function	adenosylmethionine decarboxylase activity
A	0005829	cellular_component	cytosol
A	0008295	biological_process	spermidine biosynthetic process
A	0016831	molecular_function	carboxy-lyase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 136

Chain	Residue
A	ASP19
A	ASP22
A	ASP26
A	HOH181
A	HOH226

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 137

Chain	Residue
A	GLU32
A	LYS42
A	SER45
A	TYR47

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Schiff-base intermediate with substrate; via pyruvic acid => ECO:0000255|HAMAP-Rule:MF_00464

Chain	Residue	Details
A	SER64

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton acceptor; for processing activity => ECO:0000255|HAMAP-Rule:MF_00464

Chain	Residue	Details
A	HIS69

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	ACT_SITE: Proton donor; for catalytic activity => ECO:0000255|HAMAP-Rule:MF_00464

Chain	Residue	Details
A	CYS84

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Cleavage (non-hydrolytic); by autolysis => ECO:0000255|HAMAP-Rule:MF_00464

Chain	Residue	Details
A	GLU63

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Pyruvic acid (Ser); by autocatalysis => ECO:0000255|HAMAP-Rule:MF_00464

Chain	Residue	Details
A	SER64

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