Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2IEZ

Crystal Structure of mouse Rab27b bound to GDP in monoclinic space group

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003924	molecular_function	GTPase activity
A	0003925	molecular_function	G protein activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005768	cellular_component	endosome
A	0005770	cellular_component	late endosome
A	0005794	cellular_component	Golgi apparatus
A	0005795	cellular_component	Golgi stack
A	0006887	biological_process	exocytosis
A	0012505	cellular_component	endomembrane system
A	0016020	cellular_component	membrane
A	0016324	cellular_component	apical plasma membrane
A	0016787	molecular_function	hydrolase activity
A	0017157	biological_process	regulation of exocytosis
A	0019003	molecular_function	GDP binding
A	0019904	molecular_function	protein domain specific binding
A	0030140	cellular_component	trans-Golgi network transport vesicle
A	0030141	cellular_component	secretory granule
A	0030672	cellular_component	synaptic vesicle membrane
A	0031489	molecular_function	myosin V binding
A	0032585	cellular_component	multivesicular body membrane
A	0042470	cellular_component	melanosome
A	0042589	cellular_component	zymogen granule membrane
A	0045921	biological_process	positive regulation of exocytosis
A	0048488	biological_process	synaptic vesicle endocytosis
A	0070382	cellular_component	exocytic vesicle
A	0071985	biological_process	multivesicular body sorting pathway
A	0099641	biological_process	anterograde axonal protein transport
A	1904115	cellular_component	axon cytoplasm
B	0000166	molecular_function	nucleotide binding
B	0003924	molecular_function	GTPase activity
B	0003925	molecular_function	G protein activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005768	cellular_component	endosome
B	0005770	cellular_component	late endosome
B	0005794	cellular_component	Golgi apparatus
B	0005795	cellular_component	Golgi stack
B	0006887	biological_process	exocytosis
B	0012505	cellular_component	endomembrane system
B	0016020	cellular_component	membrane
B	0016324	cellular_component	apical plasma membrane
B	0016787	molecular_function	hydrolase activity
B	0017157	biological_process	regulation of exocytosis
B	0019003	molecular_function	GDP binding
B	0019904	molecular_function	protein domain specific binding
B	0030140	cellular_component	trans-Golgi network transport vesicle
B	0030141	cellular_component	secretory granule
B	0030672	cellular_component	synaptic vesicle membrane
B	0031489	molecular_function	myosin V binding
B	0032585	cellular_component	multivesicular body membrane
B	0042470	cellular_component	melanosome
B	0042589	cellular_component	zymogen granule membrane
B	0045921	biological_process	positive regulation of exocytosis
B	0048488	biological_process	synaptic vesicle endocytosis
B	0070382	cellular_component	exocytic vesicle
B	0071985	biological_process	multivesicular body sorting pathway
B	0099641	biological_process	anterograde axonal protein transport
B	1904115	cellular_component	axon cytoplasm
H	0000166	molecular_function	nucleotide binding
H	0003924	molecular_function	GTPase activity
H	0003925	molecular_function	G protein activity
H	0005515	molecular_function	protein binding
H	0005525	molecular_function	GTP binding
H	0005737	cellular_component	cytoplasm
H	0005768	cellular_component	endosome
H	0005770	cellular_component	late endosome
H	0005794	cellular_component	Golgi apparatus
H	0005795	cellular_component	Golgi stack
H	0006887	biological_process	exocytosis
H	0012505	cellular_component	endomembrane system
H	0016020	cellular_component	membrane
H	0016324	cellular_component	apical plasma membrane
H	0016787	molecular_function	hydrolase activity
H	0017157	biological_process	regulation of exocytosis
H	0019003	molecular_function	GDP binding
H	0019904	molecular_function	protein domain specific binding
H	0030140	cellular_component	trans-Golgi network transport vesicle
H	0030141	cellular_component	secretory granule
H	0030672	cellular_component	synaptic vesicle membrane
H	0031489	molecular_function	myosin V binding
H	0032585	cellular_component	multivesicular body membrane
H	0042470	cellular_component	melanosome
H	0042589	cellular_component	zymogen granule membrane
H	0045921	biological_process	positive regulation of exocytosis
H	0048488	biological_process	synaptic vesicle endocytosis
H	0070382	cellular_component	exocytic vesicle
H	0071985	biological_process	multivesicular body sorting pathway
H	0099641	biological_process	anterograde axonal protein transport
H	1904115	cellular_component	axon cytoplasm
I	0000166	molecular_function	nucleotide binding
I	0003924	molecular_function	GTPase activity
I	0003925	molecular_function	G protein activity
I	0005515	molecular_function	protein binding
I	0005525	molecular_function	GTP binding
I	0005737	cellular_component	cytoplasm
I	0005768	cellular_component	endosome
I	0005770	cellular_component	late endosome
I	0005794	cellular_component	Golgi apparatus
I	0005795	cellular_component	Golgi stack
I	0006887	biological_process	exocytosis
I	0012505	cellular_component	endomembrane system
I	0016020	cellular_component	membrane
I	0016324	cellular_component	apical plasma membrane
I	0016787	molecular_function	hydrolase activity
I	0017157	biological_process	regulation of exocytosis
I	0019003	molecular_function	GDP binding
I	0019904	molecular_function	protein domain specific binding
I	0030140	cellular_component	trans-Golgi network transport vesicle
I	0030141	cellular_component	secretory granule
I	0030672	cellular_component	synaptic vesicle membrane
I	0031489	molecular_function	myosin V binding
I	0032585	cellular_component	multivesicular body membrane
I	0042470	cellular_component	melanosome
I	0042589	cellular_component	zymogen granule membrane
I	0045921	biological_process	positive regulation of exocytosis
I	0048488	biological_process	synaptic vesicle endocytosis
I	0070382	cellular_component	exocytic vesicle
I	0071985	biological_process	multivesicular body sorting pathway
I	0099641	biological_process	anterograde axonal protein transport
I	1904115	cellular_component	axon cytoplasm

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA B 219

Chain	Residue
B	THR23
B	GDP1001

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA A 219

Chain	Residue
A	THR23
A	GDP2001

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA I 301

Chain	Residue
I	THR23
I	GDP3001

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA H 401

Chain	Residue
H	THR23
H	GDP4001

site_id	AC5
Number of Residues	19
Details	BINDING SITE FOR RESIDUE GDP B 1001

Chain	Residue
A	PRO36
A	LYS37
A	HOH2012
B	ASP17
B	SER18
B	GLY19
B	VAL20
B	GLY21
B	LYS22
B	THR23
B	THR24
B	ASN133
B	LYS134
B	ASP136
B	SER163
B	ALA164
B	ALA165
B	CA219
A	ASN35

site_id	AC6
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GDP A 2001

Chain	Residue
A	GLY19
A	VAL20
A	GLY21
A	LYS22
A	THR23
A	THR24
A	ASN133
A	LYS134
A	ASP136
A	LEU137
A	SER163
A	ALA164
A	CA219

site_id	AC7
Number of Residues	14
Details	BINDING SITE FOR RESIDUE GDP I 3001

Chain	Residue
B	LYS183
I	ASP17
I	GLY19
I	VAL20
I	GLY21
I	LYS22
I	THR23
I	THR24
I	LYS134
I	ASP136
I	LEU137
I	ALA164
I	ALA165
I	CA301

site_id	AC8
Number of Residues	15
Details	BINDING SITE FOR RESIDUE GDP H 4001

Chain	Residue
H	ASP17
H	GLY19
H	VAL20
H	GLY21
H	LYS22
H	THR23
H	THR24
H	ASN133
H	LYS134
H	ASP136
H	LEU137
H	SER163
H	ALA164
H	ALA165
H	CA401

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	Motif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	68
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18940604","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	LEU78

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
B	LEU78

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
H	LEU78

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
I	LEU78

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	GLY19

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
B	GLY19

site_id	CSA7
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
H	GLY19

site_id	CSA8
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
I	GLY19

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)