2IES
Crystal Structure of Aquifex aeolicus LpxC Complexed with Pyrophosphate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006796 | biological_process | phosphate-containing compound metabolic process |
| A | 0008759 | molecular_function | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity |
| A | 0009245 | biological_process | lipid A biosynthetic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019637 | biological_process | organophosphate metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0103117 | molecular_function | UDP-3-O-acyl-N-acetylglucosamine deacetylase activity |
| A | 1901135 | biological_process | carbohydrate derivative metabolic process |
| B | 0006796 | biological_process | phosphate-containing compound metabolic process |
| B | 0008759 | molecular_function | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity |
| B | 0009245 | biological_process | lipid A biosynthetic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0019637 | biological_process | organophosphate metabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0103117 | molecular_function | UDP-3-O-acyl-N-acetylglucosamine deacetylase activity |
| B | 1901135 | biological_process | carbohydrate derivative metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 602 |
| Chain | Residue |
| A | CL608 |
| B | HIS58 |
| B | POP700 |
| B | PLM802 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 603 |
| Chain | Residue |
| A | HIS79 |
| A | HIS238 |
| A | ASP242 |
| A | PLM801 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE POP A 701 |
| Chain | Residue |
| A | HIS58 |
| A | LYS239 |
| A | HIS265 |
| A | ZN604 |
| A | ASN57 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 604 |
| Chain | Residue |
| A | HIS58 |
| A | CL607 |
| A | POP701 |
| A | PLM801 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN A 606 |
| Chain | Residue |
| A | VAL254 |
| A | LYS255 |
| A | HOH814 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PLM A 801 |
| Chain | Residue |
| A | HIS58 |
| A | GLU78 |
| A | HIS79 |
| A | THR191 |
| A | ILE198 |
| A | HIS238 |
| A | ASP242 |
| A | HIS265 |
| A | ZN603 |
| A | ZN604 |
| A | CL607 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 605 |
| Chain | Residue |
| B | HIS79 |
| B | HIS238 |
| B | ASP242 |
| B | PLM802 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 607 |
| Chain | Residue |
| A | PHE192 |
| A | GLU197 |
| A | ZN604 |
| A | PLM801 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE POP B 700 |
| Chain | Residue |
| A | ZN602 |
| B | ASN57 |
| B | HIS58 |
| B | LYS239 |
| B | HIS265 |
| B | PLM802 |
| B | HOH806 |
| B | HOH807 |
| site_id | BC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE PLM B 802 |
| Chain | Residue |
| A | ZN602 |
| A | ZN605 |
| A | CL608 |
| B | HIS58 |
| B | GLU78 |
| B | HIS79 |
| B | THR191 |
| B | ILE198 |
| B | ILE201 |
| B | GLY210 |
| B | SER211 |
| B | LEU212 |
| B | HIS238 |
| B | ASP242 |
| B | HIS265 |
| B | POP700 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 608 |
| Chain | Residue |
| A | ZN602 |
| B | GLU197 |
| B | PLM802 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor => ECO:0000255|HAMAP-Rule:MF_00388, ECO:0000305|PubMed:15705580 |
| Chain | Residue | Details |
| A | HIS265 | |
| B | HIS265 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00388, ECO:0000269|PubMed:12819349, ECO:0000269|PubMed:15705580, ECO:0007744|PDB:1P42, ECO:0007744|PDB:1YH8, ECO:0007744|PDB:1YHC |
| Chain | Residue | Details |
| A | HIS79 | |
| A | HIS238 | |
| A | ASP242 | |
| B | HIS79 | |
| B | HIS238 | |
| B | ASP242 |
