2ICS

Crystal structure of an adenine deaminase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016787	molecular_function	hydrolase activity
A	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
A	0019213	molecular_function	deacetylase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ZN A 400

Chain	Residue
A	HIS60
A	HIS62
A	TYR70
A	KCX154
A	ASP272
A	ZN401
A	HOH1115

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN A 401

Chain	Residue
A	HIS211
A	ZN400
A	ADE1114
A	HOH1115
A	KCX154
A	HIS188

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ADE A 1114

Chain	Residue
A	TYR70
A	GLN125
A	ARG156
A	HIS188
A	ZN401
A	HOH1115

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:23214420

Chain	Residue	Details
A	HIS60
A	HIS62
A	HIS188
A	HIS211
A	ASP272

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: via carbamate group => ECO:0000269|PubMed:23214420

Chain	Residue	Details
A	KCX154

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Transition state stabilizer => ECO:0000250

Chain	Residue	Details
A	ARG156

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-carboxylysine => ECO:0000269|PubMed:23214420

Chain	Residue	Details
A	KCX154

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