2ICK
Human isopentenyl diphophate isomerase complexed with substrate analog
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004452 | molecular_function | isopentenyl-diphosphate delta-isomerase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005777 | cellular_component | peroxisome |
| A | 0005829 | cellular_component | cytosol |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006694 | biological_process | steroid biosynthetic process |
| A | 0006695 | biological_process | cholesterol biosynthetic process |
| A | 0008202 | biological_process | steroid metabolic process |
| A | 0008203 | biological_process | cholesterol metabolic process |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0009240 | biological_process | isopentenyl diphosphate biosynthetic process |
| A | 0016126 | biological_process | sterol biosynthetic process |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0016860 | molecular_function | intramolecular oxidoreductase activity |
| A | 0035634 | biological_process | response to stilbenoid |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050992 | biological_process | dimethylallyl diphosphate biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN A 229 |
| Chain | Residue |
| A | HIS41 |
| A | HIS52 |
| A | HIS89 |
| A | GLU147 |
| A | GLU149 |
| A | DMA301 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE DMA A 301 |
| Chain | Residue |
| A | ARG71 |
| A | LYS75 |
| A | THR77 |
| A | CYS87 |
| A | SER88 |
| A | HIS89 |
| A | TYR137 |
| A | GLU147 |
| A | GLU149 |
| A | ASP151 |
| A | TRP197 |
| A | MN229 |
| A | HOH448 |
| A | HOH454 |
| A | LYS37 |
| A | ALA54 |
| A | PHE55 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: |
| Chain | Residue | Details |
| A | CYS86 | |
| A | HIS148 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17250851 |
| Chain | Residue | Details |
| A | THR36 | |
| A | GLN70 | |
| A | ALA74 | |
| A | CYS87 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | CYS40 | |
| A | LEU51 | |
| A | GLY146 | |
| A | HIS148 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | SER176 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1i9a |
| Chain | Residue | Details |
| A | GLU149 | |
| A | CYS87 | |
| A | TRP197 | |
| A | GLU116 |
