2ICK

Human isopentenyl diphophate isomerase complexed with substrate analog

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004452	molecular_function	isopentenyl-diphosphate delta-isomerase activity
A	0005737	cellular_component	cytoplasm
A	0005777	cellular_component	peroxisome
A	0005829	cellular_component	cytosol
A	0006695	biological_process	cholesterol biosynthetic process
A	0008299	biological_process	isoprenoid biosynthetic process
A	0009240	biological_process	isopentenyl diphosphate biosynthetic process
A	0016853	molecular_function	isomerase activity
A	0046872	molecular_function	metal ion binding
A	0050992	biological_process	dimethylallyl diphosphate biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 229

Chain	Residue
A	HIS41
A	HIS52
A	HIS89
A	GLU147
A	GLU149
A	DMA301

---

site_id	AC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE DMA A 301

Chain	Residue
A	ARG71
A	LYS75
A	THR77
A	CYS87
A	SER88
A	HIS89
A	TYR137
A	GLU147
A	GLU149
A	ASP151
A	TRP197
A	MN229
A	HOH448
A	HOH454
A	LYS37
A	ALA54
A	PHE55

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE:

Chain	Residue	Details
A	CYS86
A	HIS148

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:17250851

Chain	Residue	Details
A	THR36
A	GLN70
A	ALA74
A	CYS87

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING:

Chain	Residue	Details
A	CYS40
A	LEU51
A	GLY146
A	HIS148

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	SER176

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1i9a

Chain	Residue	Details
A	GLU149
A	CYS87
A	TRP197
A	GLU116

---