2IAN
Structural basis for recognition of mutant self by a tumor-specific, MHC class II-restricted TCR
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0006955 | biological_process | immune response |
A | 0016020 | cellular_component | membrane |
A | 0019882 | biological_process | antigen processing and presentation |
A | 0042613 | cellular_component | MHC class II protein complex |
B | 0006955 | biological_process | immune response |
B | 0016020 | cellular_component | membrane |
B | 0019882 | biological_process | antigen processing and presentation |
B | 0042613 | cellular_component | MHC class II protein complex |
F | 0006955 | biological_process | immune response |
F | 0016020 | cellular_component | membrane |
F | 0019882 | biological_process | antigen processing and presentation |
F | 0042613 | cellular_component | MHC class II protein complex |
G | 0006955 | biological_process | immune response |
G | 0016020 | cellular_component | membrane |
G | 0019882 | biological_process | antigen processing and presentation |
G | 0042613 | cellular_component | MHC class II protein complex |
K | 0006955 | biological_process | immune response |
K | 0016020 | cellular_component | membrane |
K | 0019882 | biological_process | antigen processing and presentation |
K | 0042613 | cellular_component | MHC class II protein complex |
L | 0006955 | biological_process | immune response |
L | 0016020 | cellular_component | membrane |
L | 0019882 | biological_process | antigen processing and presentation |
L | 0042613 | cellular_component | MHC class II protein complex |
P | 0006955 | biological_process | immune response |
P | 0016020 | cellular_component | membrane |
P | 0019882 | biological_process | antigen processing and presentation |
P | 0042613 | cellular_component | MHC class II protein complex |
Q | 0006955 | biological_process | immune response |
Q | 0016020 | cellular_component | membrane |
Q | 0019882 | biological_process | antigen processing and presentation |
Q | 0042613 | cellular_component | MHC class II protein complex |
Functional Information from PROSITE/UniProt
site_id | PS00290 |
Number of Residues | 7 |
Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCQVEH |
Chain | Residue | Details |
B | TYR171-HIS177 | |
A | TYR161-HIS167 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 |
Chain | Residue | Details |
E | ASN180 | |
L | TRP61 | |
L | HIS81 | |
L | ASN82 | |
Q | ASP57 | |
Q | TRP61 | |
Q | HIS81 | |
Q | ASN82 | |
J | ASN180 | |
O | ASN180 | |
T | ASN180 | |
N | ASN141 | |
N | ASN175 | |
S | ASN141 | |
S | ASN175 | |
L | ASP57 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 |
Chain | Residue | Details |
D | ASN186 | |
I | ASN186 | |
N | ASN186 | |
S | ASN186 | |
K | GLY49 | |
K | ALA52 | |
P | GLY49 | |
P | ALA52 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19303388, ECO:0000269|PubMed:24190431 |
Chain | Residue | Details |
B | ASN19 | |
G | ASN19 | |
L | ASN19 | |
Q | ASN19 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | SITE: Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819 |
Chain | Residue | Details |
A | SER53 | |
F | SER53 | |
K | SER53 | |
P | SER53 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | SITE: Pathogen-derived peptide antigen => ECO:0000269|PubMed:23260142, ECO:0007744|PDB:4GBX |
Chain | Residue | Details |
A | GLU55 | |
F | GLU55 | |
K | GLU55 | |
P | GLU55 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | SITE: Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4GBX |
Chain | Residue | Details |
A | ASN62 | |
F | ASN62 | |
K | ASN62 | |
P | ASN62 |
site_id | SWS_FT_FI7 |
Number of Residues | 4 |
Details | SITE: Pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX |
Chain | Residue | Details |
A | ASN69 | |
F | ASN69 | |
K | ASN69 | |
P | ASN69 |
site_id | SWS_FT_FI8 |
Number of Residues | 4 |
Details | SITE: Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX |
Chain | Residue | Details |
A | ARG76 | |
F | ARG76 | |
K | ARG76 | |
P | ARG76 |
site_id | SWS_FT_FI9 |
Number of Residues | 8 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400 |
Chain | Residue | Details |
A | ASN78 | |
A | ASN118 | |
F | ASN78 | |
F | ASN118 | |
K | ASN78 | |
K | ASN118 | |
P | ASN78 | |
P | ASN118 |