2I99

Crystal structure of human Mu_crystallin at 2.6 Angstrom

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0003714	molecular_function	transcription corepressor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005782	cellular_component	peroxisomal matrix
A	0005829	cellular_component	cytosol
A	0006554	biological_process	lysine catabolic process
A	0007605	biological_process	sensory perception of sound
A	0016491	molecular_function	oxidoreductase activity
A	0042403	biological_process	thyroid hormone metabolic process
A	0042562	molecular_function	hormone binding
A	0042803	molecular_function	protein homodimerization activity
A	0047125	molecular_function	delta1-piperideine-2-carboxylate reductase activity
A	0047127	molecular_function	thiomorpholine-carboxylate dehydrogenase activity
A	0050241	molecular_function	pyrroline-2-carboxylate reductase activity
A	0050661	molecular_function	NADP binding
A	0070062	cellular_component	extracellular exosome
A	0070324	molecular_function	thyroid hormone binding
A	0070327	biological_process	thyroid hormone transport
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0003714	molecular_function	transcription corepressor activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005782	cellular_component	peroxisomal matrix
B	0005829	cellular_component	cytosol
B	0006554	biological_process	lysine catabolic process
B	0007605	biological_process	sensory perception of sound
B	0016491	molecular_function	oxidoreductase activity
B	0042403	biological_process	thyroid hormone metabolic process
B	0042562	molecular_function	hormone binding
B	0042803	molecular_function	protein homodimerization activity
B	0047125	molecular_function	delta1-piperideine-2-carboxylate reductase activity
B	0047127	molecular_function	thiomorpholine-carboxylate dehydrogenase activity
B	0050241	molecular_function	pyrroline-2-carboxylate reductase activity
B	0050661	molecular_function	NADP binding
B	0070062	cellular_component	extracellular exosome
B	0070324	molecular_function	thyroid hormone binding
B	0070327	biological_process	thyroid hormone transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	30
Details	BINDING SITE FOR RESIDUE NDP A 502

Chain	Residue
A	ASP82
A	VAL146
A	GLN147
A	ASN168
A	ARG169
A	THR170
A	ASN173
A	VAL204
A	THR205
A	LEU206
A	ALA207
A	SER91
A	VAL226
A	GLY227
A	ALA228
A	SER292
A	LEU293
A	GLY294
A	HOH504
A	HOH522
A	HOH523
A	HOH528
A	HIS92
A	HOH549
A	THR116
A	ARG119
A	THR120
A	GLY143
A	ALA144
A	GLY145

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site_id	AC2
Number of Residues	26
Details	BINDING SITE FOR RESIDUE NDP B 501

Chain	Residue
B	ASP82
B	HIS92
B	ARG119
B	THR120
B	GLY143
B	ALA144
B	GLY145
B	VAL146
B	GLN147
B	ASN168
B	ARG169
B	THR170
B	ASN173
B	VAL204
B	THR205
B	LEU206
B	ALA207
B	VAL226
B	GLY227
B	SER292
B	LEU293
B	GLY294
B	HOH510
B	HOH512
B	HOH518
B	HOH535

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"O54983","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	30
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17242435","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2I99","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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