2I7P
Crystal structure of human PANK3 in complex with AcCoA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004594 | molecular_function | pantothenate kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0015937 | biological_process | coenzyme A biosynthetic process |
| A | 0016310 | biological_process | phosphorylation |
| A | 0019842 | molecular_function | vitamin binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 1905502 | molecular_function | acetyl-CoA binding |
| B | 0004594 | molecular_function | pantothenate kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0015937 | biological_process | coenzyme A biosynthetic process |
| B | 0016310 | biological_process | phosphorylation |
| B | 0019842 | molecular_function | vitamin binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 1905502 | molecular_function | acetyl-CoA binding |
| C | 0004594 | molecular_function | pantothenate kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0015937 | biological_process | coenzyme A biosynthetic process |
| C | 0016310 | biological_process | phosphorylation |
| C | 0019842 | molecular_function | vitamin binding |
| C | 0042803 | molecular_function | protein homodimerization activity |
| C | 1905502 | molecular_function | acetyl-CoA binding |
| D | 0004594 | molecular_function | pantothenate kinase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0015937 | biological_process | coenzyme A biosynthetic process |
| D | 0016310 | biological_process | phosphorylation |
| D | 0019842 | molecular_function | vitamin binding |
| D | 0042803 | molecular_function | protein homodimerization activity |
| D | 1905502 | molecular_function | acetyl-CoA binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE ACO A 1604 |
| Chain | Residue |
| A | GLY191 |
| A | HOH1640 |
| A | HOH1685 |
| A | HOH1704 |
| C | TYR254 |
| C | ALA267 |
| C | VAL268 |
| C | ALA269 |
| C | ASN299 |
| C | TYR336 |
| C | TYR340 |
| A | SER192 |
| C | TRP341 |
| A | GLY193 |
| A | VAL194 |
| A | SER195 |
| A | ARG207 |
| A | THR211 |
| A | ASN322 |
| A | HOH1632 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE ACO B 1704 |
| Chain | Residue |
| B | GLY191 |
| B | SER192 |
| B | GLY193 |
| B | VAL194 |
| B | SER195 |
| B | ARG207 |
| B | THR211 |
| B | HOH1716 |
| B | HOH1761 |
| B | HOH1769 |
| D | TYR254 |
| D | ALA267 |
| D | VAL268 |
| D | ALA269 |
| D | TYR336 |
| D | TYR340 |
| D | TRP341 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE ACO C 1804 |
| Chain | Residue |
| A | TYR254 |
| A | VAL268 |
| A | ALA269 |
| A | ASN299 |
| A | TYR336 |
| A | TYR340 |
| A | TRP341 |
| C | GLY191 |
| C | SER192 |
| C | GLY193 |
| C | VAL194 |
| C | SER195 |
| C | ARG207 |
| C | THR211 |
| C | ASN322 |
| C | HOH1933 |
| site_id | AC4 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE ACO D 1904 |
| Chain | Residue |
| B | TYR254 |
| B | VAL268 |
| B | ALA269 |
| B | ASN299 |
| B | TYR336 |
| B | TYR340 |
| B | TRP341 |
| D | GLY191 |
| D | SER192 |
| D | GLY193 |
| D | VAL194 |
| D | SER195 |
| D | ARG207 |
| D | THR211 |
| D | HOH1937 |
| D | HOH1949 |
| D | HOH2057 |
| D | HOH2060 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"27555321","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17631502","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17631502","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20797618","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
