2I7P

Crystal structure of human PANK3 in complex with AcCoA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004594	molecular_function	pantothenate kinase activity
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0015937	biological_process	coenzyme A biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016310	biological_process	phosphorylation
A	0016740	molecular_function	transferase activity
A	0019842	molecular_function	vitamin binding
A	0042803	molecular_function	protein homodimerization activity
A	1905502	molecular_function	acetyl-CoA binding
B	0000166	molecular_function	nucleotide binding
B	0004594	molecular_function	pantothenate kinase activity
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0015937	biological_process	coenzyme A biosynthetic process
B	0016301	molecular_function	kinase activity
B	0016310	biological_process	phosphorylation
B	0016740	molecular_function	transferase activity
B	0019842	molecular_function	vitamin binding
B	0042803	molecular_function	protein homodimerization activity
B	1905502	molecular_function	acetyl-CoA binding
C	0000166	molecular_function	nucleotide binding
C	0004594	molecular_function	pantothenate kinase activity
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0015937	biological_process	coenzyme A biosynthetic process
C	0016301	molecular_function	kinase activity
C	0016310	biological_process	phosphorylation
C	0016740	molecular_function	transferase activity
C	0019842	molecular_function	vitamin binding
C	0042803	molecular_function	protein homodimerization activity
C	1905502	molecular_function	acetyl-CoA binding
D	0000166	molecular_function	nucleotide binding
D	0004594	molecular_function	pantothenate kinase activity
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0015937	biological_process	coenzyme A biosynthetic process
D	0016301	molecular_function	kinase activity
D	0016310	biological_process	phosphorylation
D	0016740	molecular_function	transferase activity
D	0019842	molecular_function	vitamin binding
D	0042803	molecular_function	protein homodimerization activity
D	1905502	molecular_function	acetyl-CoA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ACO A 1604

Chain	Residue
A	GLY191
A	HOH1640
A	HOH1685
A	HOH1704
C	TYR254
C	ALA267
C	VAL268
C	ALA269
C	ASN299
C	TYR336
C	TYR340
A	SER192
C	TRP341
A	GLY193
A	VAL194
A	SER195
A	ARG207
A	THR211
A	ASN322
A	HOH1632

---

site_id	AC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ACO B 1704

Chain	Residue
B	GLY191
B	SER192
B	GLY193
B	VAL194
B	SER195
B	ARG207
B	THR211
B	HOH1716
B	HOH1761
B	HOH1769
D	TYR254
D	ALA267
D	VAL268
D	ALA269
D	TYR336
D	TYR340
D	TRP341

---

site_id	AC3
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ACO C 1804

Chain	Residue
A	TYR254
A	VAL268
A	ALA269
A	ASN299
A	TYR336
A	TYR340
A	TRP341
C	GLY191
C	SER192
C	GLY193
C	VAL194
C	SER195
C	ARG207
C	THR211
C	ASN322
C	HOH1933

---

site_id	AC4
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ACO D 1904

Chain	Residue
B	TYR254
B	VAL268
B	ALA269
B	ASN299
B	TYR336
B	TYR340
B	TRP341
D	GLY191
D	SER192
D	GLY193
D	VAL194
D	SER195
D	ARG207
D	THR211
D	HOH1937
D	HOH1949
D	HOH2057
D	HOH2060

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"27555321","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17631502","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17631502","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20797618","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---