2I6U
Crystal Structure of Ornithine Carbamoyltransferase complexed with Carbamoyl Phosphate and L-Norvaline from Mycobacterium tuberculosis (Rv1656) at 2.2 A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0006526 | biological_process | L-arginine biosynthetic process |
| A | 0006591 | biological_process | ornithine metabolic process |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0016597 | molecular_function | amino acid binding |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| A | 0019240 | biological_process | citrulline biosynthetic process |
| A | 0042450 | biological_process | L-arginine biosynthetic process via ornithine |
| B | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0006526 | biological_process | L-arginine biosynthetic process |
| B | 0006591 | biological_process | ornithine metabolic process |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0016597 | molecular_function | amino acid binding |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| B | 0019240 | biological_process | citrulline biosynthetic process |
| B | 0042450 | biological_process | L-arginine biosynthetic process via ornithine |
| C | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006520 | biological_process | amino acid metabolic process |
| C | 0006526 | biological_process | L-arginine biosynthetic process |
| C | 0006591 | biological_process | ornithine metabolic process |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0016597 | molecular_function | amino acid binding |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| C | 0019240 | biological_process | citrulline biosynthetic process |
| C | 0042450 | biological_process | L-arginine biosynthetic process via ornithine |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 800 |
| Chain | Residue |
| A | ARG34 |
| A | GLN37 |
| A | HOH805 |
| B | ARG34 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 801 |
| Chain | Residue |
| A | HOH922 |
| A | ASN248 |
| A | SER249 |
| A | THR274 |
| A | HOH812 |
| A | HOH862 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 801 |
| Chain | Residue |
| B | ASN248 |
| B | SER249 |
| B | THR274 |
| B | HOH881 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 801 |
| Chain | Residue |
| C | ASN248 |
| C | SER249 |
| C | THR274 |
| C | ALA276 |
| C | HOH867 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 802 |
| Chain | Residue |
| C | ARG243 |
| C | ASN248 |
| C | HOH845 |
| C | HOH974 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE CP A 500 |
| Chain | Residue |
| A | SER50 |
| A | THR51 |
| A | ARG52 |
| A | THR53 |
| A | ARG101 |
| A | HIS128 |
| A | GLN131 |
| A | CYS264 |
| A | LEU265 |
| A | ARG292 |
| A | NVA600 |
| C | GLN77 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE NVA A 600 |
| Chain | Residue |
| A | ASN159 |
| A | ASN160 |
| A | ASP224 |
| A | SER228 |
| A | MET229 |
| A | LEU265 |
| A | CP500 |
| A | HOH830 |
| A | HOH858 |
| site_id | AC8 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE CP B 501 |
| Chain | Residue |
| A | GLN77 |
| B | SER50 |
| B | THR51 |
| B | ARG52 |
| B | THR53 |
| B | ARG101 |
| B | HIS128 |
| B | GLN131 |
| B | CYS264 |
| B | LEU265 |
| B | ARG292 |
| B | NVA601 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE NVA B 601 |
| Chain | Residue |
| A | HOH853 |
| B | LEU123 |
| B | ASN160 |
| B | ASP224 |
| B | SER228 |
| B | MET229 |
| B | LEU265 |
| B | CP501 |
| B | HOH858 |
| site_id | BC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE CP C 502 |
| Chain | Residue |
| B | GLN77 |
| C | SER50 |
| C | THR51 |
| C | ARG52 |
| C | THR53 |
| C | ARG101 |
| C | HIS128 |
| C | GLN131 |
| C | CYS264 |
| C | LEU265 |
| C | ARG292 |
| C | NVA602 |
| site_id | BC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE NVA C 602 |
| Chain | Residue |
| B | HOH815 |
| C | LEU123 |
| C | HIS128 |
| C | ASN159 |
| C | ASN160 |
| C | ASP224 |
| C | SER228 |
| C | MET229 |
| C | LEU265 |
| C | CP502 |
| C | HOH808 |
Functional Information from PROSITE/UniProt
| site_id | PS00097 |
| Number of Residues | 8 |
| Details | CARBAMOYLTRANSFERASE Aspartate and ornithine carbamoyltransferases signature. FdKnSTRT |
| Chain | Residue | Details |
| A | PHE46-THR53 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 39 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18062991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2I6U","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1akm |
| Chain | Residue | Details |
| A | CYS264 | |
| A | ASP224 | |
| A | ARG292 | |
| A | GLN131 | |
| A | ARG101 | |
| A | HIS128 |
| site_id | CSA2 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1akm |
| Chain | Residue | Details |
| B | CYS264 | |
| B | ASP224 | |
| B | ARG292 | |
| B | GLN131 | |
| B | ARG101 | |
| B | HIS128 |
| site_id | CSA3 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1akm |
| Chain | Residue | Details |
| C | CYS264 | |
| C | ASP224 | |
| C | ARG292 | |
| C | GLN131 | |
| C | ARG101 | |
| C | HIS128 |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1akm |
| Chain | Residue | Details |
| A | ARG52 | |
| A | THR53 | |
| A | ARG101 | |
| A | HIS128 |
| site_id | CSA5 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1akm |
| Chain | Residue | Details |
| B | ARG52 | |
| B | THR53 | |
| B | ARG101 | |
| B | HIS128 |
| site_id | CSA6 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1akm |
| Chain | Residue | Details |
| C | ARG52 | |
| C | THR53 | |
| C | ARG101 | |
| C | HIS128 |
