2I5P

Crystal structure of glyceraldehyde-3-phosphate dehydrogenase isoform 1 from K. marxianus

Functional Information from GO Data

Chain	GOid	namespace	contents
O	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0006006	biological_process	glucose metabolic process
O	0006096	biological_process	glycolytic process
O	0016491	molecular_function	oxidoreductase activity
O	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
O	0030312	cellular_component	external encapsulating structure
O	0050661	molecular_function	NADP binding
O	0051287	molecular_function	NAD binding
P	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0006006	biological_process	glucose metabolic process
P	0006096	biological_process	glycolytic process
P	0016491	molecular_function	oxidoreductase activity
P	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
P	0030312	cellular_component	external encapsulating structure
P	0050661	molecular_function	NADP binding
P	0051287	molecular_function	NAD binding

Functional Information from PROSITE/UniProt

site_id	PS00071
Number of Residues	8
Details	GAPDH Glyceraldehyde 3-phosphate dehydrogenase active site. ASCTTNcL

Chain	Residue	Details
O	ALA147-LEU154

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Nucleophile => ECO:0000250|UniProtKB:P22513, ECO:0000255|PROSITE-ProRule:PRU10009

Chain	Residue	Details
O	CYS149
P	CYS649

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site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P22513

Chain	Residue	Details
O	GLU76
O	SER148
O	THR179
O	THR208
O	ARG231
O	ASN313
P	ARG510
P	ASP532
P	GLU576
P	SER648
P	THR679
P	THR708
P	ARG731
P	ASN813
O	ARG10
O	ASP32

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site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Activates thiol group during catalysis => ECO:0000250|UniProtKB:P22513

Chain	Residue	Details
O	HIS176
P	HIS676

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site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P00359

Chain	Residue	Details
O	SER200
P	SER648
P	SER677
P	SER700
O	SER148
O	SER177

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