2I5B
The crystal structure of an ADP complex of Bacillus subtilis pyridoxal kinase provides evidence for the parralel emergence of enzyme activity during evolution
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005524 | molecular_function | ATP binding |
A | 0005829 | cellular_component | cytosol |
A | 0008478 | molecular_function | pyridoxal kinase activity |
A | 0008902 | molecular_function | hydroxymethylpyrimidine kinase activity |
A | 0008972 | molecular_function | phosphomethylpyrimidine kinase activity |
A | 0009228 | biological_process | thiamine biosynthetic process |
A | 0016301 | molecular_function | kinase activity |
A | 0016310 | biological_process | phosphorylation |
A | 0046872 | molecular_function | metal ion binding |
B | 0005524 | molecular_function | ATP binding |
B | 0005829 | cellular_component | cytosol |
B | 0008478 | molecular_function | pyridoxal kinase activity |
B | 0008902 | molecular_function | hydroxymethylpyrimidine kinase activity |
B | 0008972 | molecular_function | phosphomethylpyrimidine kinase activity |
B | 0009228 | biological_process | thiamine biosynthetic process |
B | 0016301 | molecular_function | kinase activity |
B | 0016310 | biological_process | phosphorylation |
B | 0046872 | molecular_function | metal ion binding |
C | 0005524 | molecular_function | ATP binding |
C | 0005829 | cellular_component | cytosol |
C | 0008478 | molecular_function | pyridoxal kinase activity |
C | 0008902 | molecular_function | hydroxymethylpyrimidine kinase activity |
C | 0008972 | molecular_function | phosphomethylpyrimidine kinase activity |
C | 0009228 | biological_process | thiamine biosynthetic process |
C | 0016301 | molecular_function | kinase activity |
C | 0016310 | biological_process | phosphorylation |
C | 0046872 | molecular_function | metal ion binding |
D | 0005524 | molecular_function | ATP binding |
D | 0005829 | cellular_component | cytosol |
D | 0008478 | molecular_function | pyridoxal kinase activity |
D | 0008902 | molecular_function | hydroxymethylpyrimidine kinase activity |
D | 0008972 | molecular_function | phosphomethylpyrimidine kinase activity |
D | 0009228 | biological_process | thiamine biosynthetic process |
D | 0016301 | molecular_function | kinase activity |
D | 0016310 | biological_process | phosphorylation |
D | 0046872 | molecular_function | metal ion binding |
E | 0005524 | molecular_function | ATP binding |
E | 0005829 | cellular_component | cytosol |
E | 0008478 | molecular_function | pyridoxal kinase activity |
E | 0008902 | molecular_function | hydroxymethylpyrimidine kinase activity |
E | 0008972 | molecular_function | phosphomethylpyrimidine kinase activity |
E | 0009228 | biological_process | thiamine biosynthetic process |
E | 0016301 | molecular_function | kinase activity |
E | 0016310 | biological_process | phosphorylation |
E | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE ADP A 301 |
Chain | Residue |
A | ASN141 |
A | ALA214 |
A | GLY215 |
A | LYS240 |
A | ILE243 |
A | ILE247 |
A | THR178 |
A | GLY180 |
A | GLY181 |
A | LYS182 |
A | ALA188 |
A | ASP190 |
A | GLU204 |
A | ILE206 |
site_id | AC2 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE ADP C 401 |
Chain | Residue |
C | ASN141 |
C | THR178 |
C | GLY180 |
C | GLY181 |
C | LYS182 |
C | ALA188 |
C | ASP190 |
C | GLU204 |
C | ILE206 |
C | ALA214 |
C | GLY215 |
C | LYS240 |
C | ILE243 |
C | ILE247 |
site_id | AC3 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE ADP D 501 |
Chain | Residue |
D | ASN141 |
D | THR178 |
D | GLY180 |
D | GLY181 |
D | LYS182 |
D | ALA188 |
D | ASP190 |
D | GLU204 |
D | ILE206 |
D | ALA214 |
D | GLY215 |
D | LYS240 |
D | ILE243 |
D | ILE247 |
site_id | AC4 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE ADP B 601 |
Chain | Residue |
B | ASN141 |
B | THR178 |
B | GLY180 |
B | GLY181 |
B | LYS182 |
B | ALA188 |
B | ASP190 |
B | GLU204 |
B | ILE206 |
B | ALA214 |
B | GLY215 |
B | LYS240 |
B | ILE243 |
B | ILE247 |
site_id | AC5 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE ADP E 701 |
Chain | Residue |
E | ASN141 |
E | THR178 |
E | GLY180 |
E | GLY181 |
E | LYS182 |
E | ALA188 |
E | ASP190 |
E | GLU204 |
E | ILE206 |
E | ALA214 |
E | GLY215 |
E | LYS240 |
E | ILE243 |
E | ILE247 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 30 |
Details | BINDING: |
Chain | Residue | Details |
A | ASN141 | |
C | ILE206 | |
C | GLY215 | |
C | LYS240 | |
D | ASN141 | |
D | THR178 | |
D | ASP190 | |
D | ILE206 | |
D | GLY215 | |
D | LYS240 | |
B | ASN141 | |
A | THR178 | |
B | THR178 | |
B | ASP190 | |
B | ILE206 | |
B | GLY215 | |
B | LYS240 | |
E | ASN141 | |
E | THR178 | |
E | ASP190 | |
E | ILE206 | |
E | GLY215 | |
A | ASP190 | |
E | LYS240 | |
A | ILE206 | |
A | GLY215 | |
A | LYS240 | |
C | ASN141 | |
C | THR178 | |
C | ASP190 |
site_id | SWS_FT_FI2 |
Number of Residues | 5 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | GLU144 | |
C | GLU144 | |
D | GLU144 | |
B | GLU144 | |
E | GLU144 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1tz3 |
Chain | Residue | Details |
A | GLY215 | |
A | CYS216 | |
A | GLY213 | |
A | ALA214 |
site_id | CSA2 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1tz3 |
Chain | Residue | Details |
C | GLY215 | |
C | CYS216 | |
C | GLY213 | |
C | ALA214 |
site_id | CSA3 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1tz3 |
Chain | Residue | Details |
D | GLY215 | |
D | CYS216 | |
D | GLY213 | |
D | ALA214 |
site_id | CSA4 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1tz3 |
Chain | Residue | Details |
B | GLY215 | |
B | CYS216 | |
B | GLY213 | |
B | ALA214 |
site_id | CSA5 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1tz3 |
Chain | Residue | Details |
E | GLY215 | |
E | CYS216 | |
E | GLY213 | |
E | ALA214 |