2I44

Crystal structure of serine-threonine phosphatase 2C from Toxoplasma gondii

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004722	molecular_function	protein serine/threonine phosphatase activity
A	0005634	cellular_component	nucleus
A	0005829	cellular_component	cytosol
A	0006470	biological_process	protein dephosphorylation
A	0032873	biological_process	negative regulation of stress-activated MAPK cascade
A	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
A	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
A	0046872	molecular_function	metal ion binding
A	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
B	0004722	molecular_function	protein serine/threonine phosphatase activity
B	0005634	cellular_component	nucleus
B	0005829	cellular_component	cytosol
B	0006470	biological_process	protein dephosphorylation
B	0032873	biological_process	negative regulation of stress-activated MAPK cascade
B	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
B	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
B	0046872	molecular_function	metal ion binding
B	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
C	0004722	molecular_function	protein serine/threonine phosphatase activity
C	0005634	cellular_component	nucleus
C	0005829	cellular_component	cytosol
C	0006470	biological_process	protein dephosphorylation
C	0032873	biological_process	negative regulation of stress-activated MAPK cascade
C	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
C	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
C	0046872	molecular_function	metal ion binding
C	0090263	biological_process	positive regulation of canonical Wnt signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA A 401

Chain	Residue
A	ASP67
A	ASP273
A	ASP318
A	CA402
A	HOH403
A	HOH405
A	HOH408

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site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA A 402

Chain	Residue
A	CA401
A	HOH404
A	HOH405
A	HOH406
A	HOH407
A	ASP67
A	GLY68

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site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA B 403

Chain	Residue
B	ASP67
B	ASP273
B	ASP318
B	CA404
B	HOH405
B	HOH409
B	HOH410

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site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA B 404

Chain	Residue
B	ASP67
B	GLY68
B	CA403
B	HOH406
B	HOH407
B	HOH408
B	HOH410

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 405

Chain	Residue
C	ASP67
C	ASP273
C	ASP318
C	HOH407
C	HOH410
C	HOH411

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site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 406

Chain	Residue
C	ASP67
C	GLY68
C	HOH408
C	HOH409
C	HOH410
C	HOH412

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