Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| A | 0016020 | cellular_component | membrane |
| B | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| B | 0016020 | cellular_component | membrane |
| C | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| C | 0016020 | cellular_component | membrane |
| D | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| D | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN A 301 |
| Chain | Residue |
| A | GLU42 |
| A | LYS45 |
| A | HIS46 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ZN A 302 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN B 303 |
| Chain | Residue |
| B | GLU166 |
| D | HIS23 |
| D | GLU24 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE ZN B 304 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN B 305 |
| Chain | Residue |
| B | GLU42 |
| B | HIS46 |
| D | GLU166 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN C 306 |
| Chain | Residue |
| A | ASP139 |
| C | ASP65 |
| C | ASP67 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ZN D 307 |
| Chain | Residue |
| D | GLU98 |
| D | HOH429 |
| site_id | AC8 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE GLU A 401 |
| Chain | Residue |
| A | TYR61 |
| A | PRO89 |
| A | LEU90 |
| A | THR91 |
| A | ARG96 |
| A | GLY141 |
| A | SER142 |
| A | THR143 |
| A | GLU193 |
| A | TYR220 |
| A | HOH407 |
| A | HOH419 |
| A | HOH445 |
| site_id | AC9 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE GLU B 402 |
| Chain | Residue |
| B | TYR61 |
| B | PRO89 |
| B | LEU90 |
| B | THR91 |
| B | ARG96 |
| B | LEU138 |
| B | GLY141 |
| B | SER142 |
| B | THR143 |
| B | GLU193 |
| B | TYR220 |
| B | HOH410 |
| B | HOH412 |
| site_id | BC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE GLU C 403 |
| Chain | Residue |
| C | TYR61 |
| C | PRO89 |
| C | THR91 |
| C | ARG96 |
| C | LEU138 |
| C | GLY141 |
| C | SER142 |
| C | THR143 |
| C | GLU193 |
| C | HOH404 |
| C | HOH440 |
| C | HOH441 |
| site_id | BC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GLU D 404 |
| Chain | Residue |
| D | TYR61 |
| D | PRO89 |
| D | LEU90 |
| D | THR91 |
| D | ARG96 |
| D | GLY141 |
| D | SER142 |
| D | THR143 |
| D | GLU193 |
| D | HOH441 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical |
| Chain | Residue | Details |
| A | ALA134-VAL154 | |
| B | ALA134-VAL154 | |
| C | ALA134-VAL154 | |
| D | ALA134-VAL154 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 124 |
| Details | TOPO_DOM: Cytoplasmic |
| Chain | Residue | Details |
| A | PHE155-VAL181 | |
| A | GLU201-CYS206 | |
| B | PHE155-VAL181 | |
| B | GLU201-CYS206 | |
| C | PHE155-VAL181 | |
| C | GLU201-CYS206 | |
| D | PHE155-VAL181 | |
| D | GLU201-CYS206 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 60 |
| Details | INTRAMEM: Helical; Pore-forming |
| Chain | Residue | Details |
| A | ARG182-ASN197 | |
| B | ARG182-ASN197 | |
| C | ARG182-ASN197 | |
| D | ARG182-ASN197 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | INTRAMEM: |
| Chain | Residue | Details |
| A | GLU198-ILE200 | |
| B | GLU198-ILE200 | |
| C | GLU198-ILE200 | |
| D | GLU198-ILE200 | |
| Chain | Residue | Details |
| A | PRO89 | |
| B | SER142 | |
| B | THR143 | |
| B | GLU193 | |
| C | PRO89 | |
| C | THR91 | |
| C | ARG96 | |
| C | SER142 | |
| C | THR143 | |
| C | GLU193 | |
| D | PRO89 | |
| A | THR91 | |
| D | THR91 | |
| D | ARG96 | |
| D | SER142 | |
| D | THR143 | |
| D | GLU193 | |
| A | ARG96 | |
| A | SER142 | |
| A | THR143 | |
| A | GLU193 | |
| B | PRO89 | |
| B | THR91 | |
| B | ARG96 | |
| site_id | SWS_FT_FI6 |
| Number of Residues | 12 |
| Details | SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 |
| Chain | Residue | Details |
| A | ARG64 | |
| D | ARG64 | |
| D | ARG148 | |
| D | LYS240 | |
| A | ARG148 | |
| A | LYS240 | |
| B | ARG64 | |
| B | ARG148 | |
| B | LYS240 | |
| C | ARG64 | |
| C | ARG148 | |
| C | LYS240 | |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405 |
| Chain | Residue | Details |
| A | ILE121 | |
| B | ILE121 | |
| C | ILE121 | |
| D | ILE121 | |
| Chain | Residue | Details |
| A | SER150 | |
| B | SER150 | |
| C | SER150 | |
| D | SER150 | |
| Chain | Residue | Details |
| A | SER184 | |
| B | SER184 | |
| C | SER184 | |
| D | SER184 | |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000250 |
| Chain | Residue | Details |
| A | ILE200 | |
| B | ILE200 | |
| C | ILE200 | |
| D | ILE200 | |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN3 | |
| B | ASN3 | |
| C | ASN3 | |
| D | ASN3 | |
