2I3V

Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor: Structure of G725C mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN A 301

Chain	Residue
A	GLU42
A	LYS45
A	HIS46

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN A 302

Chain	Residue
A	HIS23
A	GLU24

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN B 303

Chain	Residue
B	GLU166
D	HIS23
D	GLU24

---

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ZN B 304

Chain	Residue
B	HIS23

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN B 305

Chain	Residue
B	GLU42
B	HIS46
D	GLU166

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN C 306

Chain	Residue
A	ASP139
C	ASP65
C	ASP67

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN D 307

Chain	Residue
D	GLU98
D	HOH429

---

site_id	AC8
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GLU A 401

Chain	Residue
A	TYR61
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	GLY141
A	SER142
A	THR143
A	GLU193
A	TYR220
A	HOH407
A	HOH419
A	HOH445

---

site_id	AC9
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GLU B 402

Chain	Residue
B	TYR61
B	PRO89
B	LEU90
B	THR91
B	ARG96
B	LEU138
B	GLY141
B	SER142
B	THR143
B	GLU193
B	TYR220
B	HOH410
B	HOH412

---

site_id	BC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE GLU C 403

Chain	Residue
C	TYR61
C	PRO89
C	THR91
C	ARG96
C	LEU138
C	GLY141
C	SER142
C	THR143
C	GLU193
C	HOH404
C	HOH440
C	HOH441

---

site_id	BC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GLU D 404

Chain	Residue
D	TYR61
D	PRO89
D	LEU90
D	THR91
D	ARG96
D	GLY141
D	SER142
D	THR143
D	GLU193
D	HOH441

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---