2I1O

Crystal Structure of a Nicotinate Phosphoribosyltransferase from Thermoplasma acidophilum

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004514	molecular_function	nicotinate-nucleotide diphosphorylase (carboxylating) activity
A	0004516	molecular_function	nicotinate phosphoribosyltransferase activity
A	0009435	biological_process	NAD+ biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016763	molecular_function	pentosyltransferase activity
A	0016874	molecular_function	ligase activity
A	0019363	biological_process	pyridine nucleotide biosynthetic process
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 A 501

Chain	Residue
A	ARG24
A	THR25
A	MET180
A	THR197

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 A 502

Chain	Residue
A	HOH870
A	TYR21
A	HIS182
A	LEU210
A	ASP237
A	MPD401

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 A 503

Chain	Residue
A	PRO47
A	GLY118
A	LYS299
A	PHE301
A	HOH919

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 A 504

Chain	Residue
A	ARG243
A	PHE246
A	HOH862

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 A 505

Chain	Residue
A	CYS333
A	HIS334

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 A 506

Chain	Residue
A	ARG329
A	THR331
A	HIS334
A	GLU370
A	TYR387
A	HOH865
A	HOH887

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN A 701

Chain	Residue
A	CYS330
A	CYS333
A	CYS350

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 702

Chain	Residue
A	CYS330
A	CYS348
A	CYS350
A	GLY351
A	HOH904

---

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE TRS A 601

Chain	Residue
A	ARG142
A	GLY271
A	GLY272
A	LEU273
A	GLY290
A	GLY292
A	THR293

---

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MPD A 401

Chain	Residue
A	TYR21
A	PHE138
A	THR179
A	ARG235
A	PO4502
A	HOH819

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MPD A 402

Chain	Residue
A	PHE136
A	VAL177
A	LYS206
A	TYR233
A	MET268

---

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACY A 552

Chain	Residue
A	ASP68
A	HIS364

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15753098","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15753098","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1YTK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of a zinc ion bound nicotinate phosphoribosyltransferase from Thermoplasma acidophilum.","authoringGroup":["Berkeley structural genomics center (BSGC)"]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphohistidine","evidences":[{"source":"UniProtKB","id":"P22253","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1qpr

Chain	Residue	Details
A	THR107

---