2I14
Crystal structure of nicotinate-nucleotide pyrophosphorylase from Pyrococcus furiosus
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004514 | molecular_function | nicotinate-nucleotide diphosphorylase (carboxylating) activity |
| A | 0004516 | molecular_function | nicotinate phosphoribosyltransferase activity |
| A | 0009435 | biological_process | NAD biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016763 | molecular_function | pentosyltransferase activity |
| A | 0016874 | molecular_function | ligase activity |
| A | 0019363 | biological_process | pyridine nucleotide biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004514 | molecular_function | nicotinate-nucleotide diphosphorylase (carboxylating) activity |
| B | 0004516 | molecular_function | nicotinate phosphoribosyltransferase activity |
| B | 0009435 | biological_process | NAD biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016763 | molecular_function | pentosyltransferase activity |
| B | 0016874 | molecular_function | ligase activity |
| B | 0019363 | biological_process | pyridine nucleotide biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0004514 | molecular_function | nicotinate-nucleotide diphosphorylase (carboxylating) activity |
| C | 0004516 | molecular_function | nicotinate phosphoribosyltransferase activity |
| C | 0009435 | biological_process | NAD biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016763 | molecular_function | pentosyltransferase activity |
| C | 0016874 | molecular_function | ligase activity |
| C | 0019363 | biological_process | pyridine nucleotide biosynthetic process |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0004514 | molecular_function | nicotinate-nucleotide diphosphorylase (carboxylating) activity |
| D | 0004516 | molecular_function | nicotinate phosphoribosyltransferase activity |
| D | 0009435 | biological_process | NAD biosynthetic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016763 | molecular_function | pentosyltransferase activity |
| D | 0016874 | molecular_function | ligase activity |
| D | 0019363 | biological_process | pyridine nucleotide biosynthetic process |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0004514 | molecular_function | nicotinate-nucleotide diphosphorylase (carboxylating) activity |
| E | 0004516 | molecular_function | nicotinate phosphoribosyltransferase activity |
| E | 0009435 | biological_process | NAD biosynthetic process |
| E | 0016740 | molecular_function | transferase activity |
| E | 0016763 | molecular_function | pentosyltransferase activity |
| E | 0016874 | molecular_function | ligase activity |
| E | 0019363 | biological_process | pyridine nucleotide biosynthetic process |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0004514 | molecular_function | nicotinate-nucleotide diphosphorylase (carboxylating) activity |
| F | 0004516 | molecular_function | nicotinate phosphoribosyltransferase activity |
| F | 0009435 | biological_process | NAD biosynthetic process |
| F | 0016740 | molecular_function | transferase activity |
| F | 0016763 | molecular_function | pentosyltransferase activity |
| F | 0016874 | molecular_function | ligase activity |
| F | 0019363 | biological_process | pyridine nucleotide biosynthetic process |
| F | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 391 |
| Chain | Residue |
| A | CYS327 |
| A | HIS331 |
| A | CYS344 |
| A | VAL346 |
| A | CYS347 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN A 393 |
| Chain | Residue |
| A | HIS178 |
| A | ASP209 |
| A | ASP235 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B 791 |
| Chain | Residue |
| B | HIS731 |
| B | CYS744 |
| B | VAL746 |
| B | CYS747 |
| B | CYS727 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN B 793 |
| Chain | Residue |
| B | HIS578 |
| B | ASP609 |
| B | ASP635 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN C 1391 |
| Chain | Residue |
| C | CYS1327 |
| C | HIS1331 |
| C | CYS1344 |
| C | VAL1346 |
| C | CYS1347 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN C 1393 |
| Chain | Residue |
| C | HIS1178 |
| C | ASP1209 |
| C | ASP1235 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN D 1791 |
| Chain | Residue |
| D | CYS1727 |
| D | HIS1731 |
| D | CYS1744 |
| D | VAL1746 |
| D | CYS1747 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN D 1793 |
| Chain | Residue |
| D | HIS1578 |
| D | ASP1609 |
| D | ASP1635 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN E 2391 |
| Chain | Residue |
| E | CYS2327 |
| E | HIS2331 |
| E | CYS2344 |
| E | VAL2346 |
| E | CYS2347 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN E 2393 |
| Chain | Residue |
| E | HIS2178 |
| E | ASP2209 |
| E | ASP2235 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN F 2791 |
| Chain | Residue |
| F | CYS2727 |
| F | HIS2731 |
| F | CYS2744 |
| F | VAL2746 |
| F | CYS2747 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN F 2793 |
| Chain | Residue |
| F | HIS2578 |
| F | ASP2609 |
| F | ASP2635 |
| site_id | BC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PCP A 392 |
| Chain | Residue |
| A | PHE134 |
| A | ARG137 |
| A | HIS138 |
| A | PRO177 |
| A | HIS178 |
| A | ARG233 |
| A | ASP235 |
| A | GLY270 |
| A | GLY289 |
| A | GLY290 |
| B | TYR421 |
| site_id | BC5 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PCP B 792 |
| Chain | Residue |
| A | TYR21 |
| B | HOH1 |
| B | PHE534 |
| B | ARG537 |
| B | HIS538 |
| B | PRO577 |
| B | HIS578 |
| B | ARG633 |
| B | ASP635 |
| B | GLY670 |
| B | GLY689 |
| B | GLY690 |
| site_id | BC6 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PCP C 1392 |
| Chain | Residue |
| C | PHE1134 |
| C | ARG1137 |
| C | HIS1138 |
| C | PRO1177 |
| C | HIS1178 |
| C | ARG1233 |
| C | ASP1235 |
| C | GLY1270 |
| C | GLY1289 |
| C | GLY1290 |
| D | TYR1421 |
| site_id | BC7 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PCP D 1792 |
| Chain | Residue |
| C | TYR1021 |
| D | HOH3 |
| D | PHE1534 |
| D | ARG1537 |
| D | HIS1538 |
| D | PRO1577 |
| D | HIS1578 |
| D | ARG1633 |
| D | ASP1635 |
| D | GLY1670 |
| D | GLY1689 |
| D | GLY1690 |
| site_id | BC8 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PCP E 2392 |
| Chain | Residue |
| E | HIS2178 |
| E | ARG2233 |
| E | ASP2235 |
| E | GLY2270 |
| E | GLY2289 |
| E | GLY2290 |
| F | TYR2421 |
| E | HOH7 |
| E | PHE2134 |
| E | ARG2137 |
| E | HIS2138 |
| E | PRO2177 |
| site_id | BC9 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PCP F 2792 |
| Chain | Residue |
| E | TYR2021 |
| F | HOH2 |
| F | PHE2534 |
| F | ARG2537 |
| F | HIS2538 |
| F | PRO2577 |
| F | HIS2578 |
| F | ARG2633 |
| F | ASP2635 |
| F | GLY2670 |
| F | GLY2689 |
| F | GLY2690 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1qpr |
| Chain | Residue | Details |
| F | THR2503 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1qpr |
| Chain | Residue | Details |
| A | THR103 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1qpr |
| Chain | Residue | Details |
| B | THR503 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1qpr |
| Chain | Residue | Details |
| C | THR1103 |
| site_id | CSA5 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1qpr |
| Chain | Residue | Details |
| D | THR1503 |
| site_id | CSA6 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1qpr |
| Chain | Residue | Details |
| E | THR2103 |
