2HZA

Nickel-bound full-length Escherichia coli NikR

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0001046	molecular_function	core promoter sequence-specific DNA binding
A	0001217	molecular_function	DNA-binding transcription repressor activity
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005515	molecular_function	protein binding
A	0005667	cellular_component	transcription regulator complex
A	0006355	biological_process	regulation of DNA-templated transcription
A	0010045	biological_process	response to nickel cation
A	0016151	molecular_function	nickel cation binding
A	0032993	cellular_component	protein-DNA complex
A	0042802	molecular_function	identical protein binding
A	0043565	molecular_function	sequence-specific DNA binding
A	0046872	molecular_function	metal ion binding
A	2000143	biological_process	negative regulation of DNA-templated transcription initiation
B	0000976	molecular_function	transcription cis-regulatory region binding
B	0001046	molecular_function	core promoter sequence-specific DNA binding
B	0001217	molecular_function	DNA-binding transcription repressor activity
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0005515	molecular_function	protein binding
B	0005667	cellular_component	transcription regulator complex
B	0006355	biological_process	regulation of DNA-templated transcription
B	0010045	biological_process	response to nickel cation
B	0016151	molecular_function	nickel cation binding
B	0032993	cellular_component	protein-DNA complex
B	0042802	molecular_function	identical protein binding
B	0043565	molecular_function	sequence-specific DNA binding
B	0046872	molecular_function	metal ion binding
B	2000143	biological_process	negative regulation of DNA-templated transcription initiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 3CM B 201

Chain	Residue
A	SER20
A	ARG23
A	TYR25
B	ARG3
B	THR5
B	GLU43
B	GLY124
B	HIS125

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NI B 301

Chain	Residue
B	HIS87
B	HIS89
B	CYS95
A	HIS76

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NI A 302

Chain	Residue
A	HIS87
A	HIS89
A	CYS95
B	HIS76

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING:

Chain	Residue	Details
A	HIS76
A	HIS87
A	HIS89
A	CYS95
B	HIS76
B	HIS87
B	HIS89
B	CYS95

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