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2HYW

Human Annexin A2 with Calcium bound

Functional Information from GO Data
ChainGOidnamespacecontents
A0001525biological_processangiogenesis
A0001533cellular_componentcornified envelope
A0001765biological_processmembrane raft assembly
A0001786molecular_functionphosphatidylserine binding
A0001921biological_processpositive regulation of receptor recycling
A0002020molecular_functionprotease binding
A0002091biological_processnegative regulation of receptor internalization
A0003723molecular_functionRNA binding
A0004859molecular_functionphospholipase inhibitor activity
A0004867molecular_functionserine-type endopeptidase inhibitor activity
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005544molecular_functioncalcium-dependent phospholipid binding
A0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
A0005576cellular_componentextracellular region
A0005604cellular_componentbasement membrane
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005765cellular_componentlysosomal membrane
A0005768cellular_componentendosome
A0005769cellular_componentearly endosome
A0005811cellular_componentlipid droplet
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005912cellular_componentadherens junction
A0006900biological_processvesicle budding from membrane
A0007155biological_processcell adhesion
A0007160biological_processcell-matrix adhesion
A0008092molecular_functioncytoskeletal protein binding
A0009986cellular_componentcell surface
A0010756biological_processpositive regulation of plasminogen activation
A0012506cellular_componentvesicle membrane
A0014823biological_processresponse to activity
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0016363cellular_componentnuclear matrix
A0019834molecular_functionphospholipase A2 inhibitor activity
A0030199biological_processcollagen fibril organization
A0030324biological_processlung development
A0030496cellular_componentmidbody
A0031340biological_processpositive regulation of vesicle fusion
A0031902cellular_componentlate endosome membrane
A0031982cellular_componentvesicle
A0032804biological_processnegative regulation of low-density lipoprotein particle receptor catabolic process
A0035578cellular_componentazurophil granule lumen
A0035749cellular_componentmyelin sheath adaxonal region
A0036035biological_processosteoclast development
A0042383cellular_componentsarcolemma
A0042470cellular_componentmelanosome
A0042730biological_processfibrinolysis
A0042789biological_processmRNA transcription by RNA polymerase II
A0042802molecular_functionidentical protein binding
A0043220cellular_componentSchmidt-Lanterman incisure
A0044090biological_processpositive regulation of vacuole organization
A0044548molecular_functionS100 protein binding
A0045121cellular_componentmembrane raft
A0045921biological_processpositive regulation of exocytosis
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0048306molecular_functioncalcium-dependent protein binding
A0050767biological_processregulation of neurogenesis
A0062023cellular_componentcollagen-containing extracellular matrix
A0070062cellular_componentextracellular exosome
A0090575cellular_componentRNA polymerase II transcription regulator complex
A0098609biological_processcell-cell adhesion
A0098641molecular_functioncadherin binding involved in cell-cell adhesion
A0098797cellular_componentplasma membrane protein complex
A1904019biological_processepithelial cell apoptotic process
A1905581biological_processpositive regulation of low-density lipoprotein particle clearance
A1905597biological_processpositive regulation of low-density lipoprotein particle receptor binding
A1905599biological_processpositive regulation of low-density lipoprotein receptor activity
A1905602biological_processpositive regulation of receptor-mediated endocytosis involved in cholesterol transport
A1905686biological_processpositive regulation of plasma membrane repair
A1990665cellular_componentAnxA2-p11 complex
A1990667cellular_componentPCSK9-AnxA2 complex
B0001525biological_processangiogenesis
B0001533cellular_componentcornified envelope
B0001765biological_processmembrane raft assembly
B0001786molecular_functionphosphatidylserine binding
B0001921biological_processpositive regulation of receptor recycling
B0002020molecular_functionprotease binding
B0002091biological_processnegative regulation of receptor internalization
B0003723molecular_functionRNA binding
B0004859molecular_functionphospholipase inhibitor activity
B0004867molecular_functionserine-type endopeptidase inhibitor activity
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005544molecular_functioncalcium-dependent phospholipid binding
B0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
B0005576cellular_componentextracellular region
B0005604cellular_componentbasement membrane
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005768cellular_componentendosome
B0005769cellular_componentearly endosome
B0005811cellular_componentlipid droplet
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005912cellular_componentadherens junction
B0006900biological_processvesicle budding from membrane
B0007155biological_processcell adhesion
B0007160biological_processcell-matrix adhesion
B0008092molecular_functioncytoskeletal protein binding
B0009986cellular_componentcell surface
B0010756biological_processpositive regulation of plasminogen activation
B0012506cellular_componentvesicle membrane
B0014823biological_processresponse to activity
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0016363cellular_componentnuclear matrix
B0019834molecular_functionphospholipase A2 inhibitor activity
B0030199biological_processcollagen fibril organization
B0030324biological_processlung development
B0030496cellular_componentmidbody
B0031340biological_processpositive regulation of vesicle fusion
B0031902cellular_componentlate endosome membrane
B0031982cellular_componentvesicle
B0032804biological_processnegative regulation of low-density lipoprotein particle receptor catabolic process
B0035578cellular_componentazurophil granule lumen
B0035749cellular_componentmyelin sheath adaxonal region
B0036035biological_processosteoclast development
B0042383cellular_componentsarcolemma
B0042470cellular_componentmelanosome
B0042730biological_processfibrinolysis
B0042789biological_processmRNA transcription by RNA polymerase II
B0042802molecular_functionidentical protein binding
B0043220cellular_componentSchmidt-Lanterman incisure
B0044090biological_processpositive regulation of vacuole organization
B0044548molecular_functionS100 protein binding
B0045121cellular_componentmembrane raft
B0045921biological_processpositive regulation of exocytosis
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0048306molecular_functioncalcium-dependent protein binding
B0050767biological_processregulation of neurogenesis
B0062023cellular_componentcollagen-containing extracellular matrix
B0070062cellular_componentextracellular exosome
B0090575cellular_componentRNA polymerase II transcription regulator complex
B0098609biological_processcell-cell adhesion
B0098641molecular_functioncadherin binding involved in cell-cell adhesion
B0098797cellular_componentplasma membrane protein complex
B1904019biological_processepithelial cell apoptotic process
B1905581biological_processpositive regulation of low-density lipoprotein particle clearance
B1905597biological_processpositive regulation of low-density lipoprotein particle receptor binding
B1905599biological_processpositive regulation of low-density lipoprotein receptor activity
B1905602biological_processpositive regulation of receptor-mediated endocytosis involved in cholesterol transport
B1905686biological_processpositive regulation of plasma membrane repair
B1990665cellular_componentAnxA2-p11 complex
B1990667cellular_componentPCSK9-AnxA2 complex
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 501
ChainResidue
AGLY49
AVAL50
AGLU52
AHOH626
AHOH708
AHOH713

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA A 502
ChainResidue
AHOH550
AHOH716
ALYS87
ALEU90
AGLU95

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 503
ChainResidue
AMET117
AGLY119
AGLY121
AASP161
AHOH707
AHOH717

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 504
ChainResidue
ATHR122
AGLU124
AHOH553
AHOH709
AHOH718
AHOH719

site_idAC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA A 505
ChainResidue
AGLY201
AARG204
AGLY206
AGLU246
AHOH712

site_idAC6
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 506
ChainResidue
AARG244
AVAL247
AGLU252
AHOH682
AHOH695
AHOH714

site_idAC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA A 507
ChainResidue
AMET277
AGLY279
AGLY281
AASP321
AHOH710

site_idAC8
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA B 508
ChainResidue
BGLY49
BVAL50
BGLU52
BHOH584
BHOH724
BHOH725

site_idAC9
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA B 509
ChainResidue
BLYS87
BLEU90
BGLU95
BHOH536
BHOH650

site_idBC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA B 510
ChainResidue
BMET117
BGLY119
BGLY121
BASP161
BHOH721
BHOH727

site_idBC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE CA B 511
ChainResidue
BTHR122
BGLU124
BHOH716
BHOH722
BHOH726
BHOH728
BHOH730

site_idBC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA B 512
ChainResidue
BGLY201
BARG204
BGLY206
BGLU246
BHOH630
BHOH723

site_idBC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA B 513
ChainResidue
BARG244
BVAL247
BGLU252
BHOH719
BHOH720

site_idBC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA B 514
ChainResidue
BMET277
BGLY279
BGLY281
BASP321
BHOH729

Functional Information from PROSITE/UniProt
site_idPS00223
Number of Residues53
DetailsANNEXIN_1 Annexin repeat signature. GVdevtivniLtnRsnaQrqDiafaYqrrtkkeLasaLksalsGhletvIlgL
ChainResidueDetails
AGLY49-LEU101
AGLY121-LEU173
AGLY206-LEU258
AGLY281-LEU333

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P07356
ChainResidueDetails
AGLY49
BGLY49

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P07356
ChainResidueDetails
ATHR152
AVAL227
BTHR152
BVAL227

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
AVAL184
BVAL184

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P07356
ChainResidueDetails
AASP199
BASP199

site_idSWS_FT_FI5
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733
ChainResidueDetails
AGLY49
BGLY49

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PDB entries from 2024-07-24

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