2HVW

Crystal structure of dCMP deaminase from Streptococcus mutans

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003824	molecular_function	catalytic activity
A	0004132	molecular_function	dCMP deaminase activity
A	0005737	cellular_component	cytoplasm
A	0008270	molecular_function	zinc ion binding
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0003824	molecular_function	catalytic activity
B	0004132	molecular_function	dCMP deaminase activity
B	0005737	cellular_component	cytoplasm
B	0008270	molecular_function	zinc ion binding
B	0016787	molecular_function	hydrolase activity
B	0046872	molecular_function	metal ion binding
C	0000166	molecular_function	nucleotide binding
C	0003824	molecular_function	catalytic activity
C	0004132	molecular_function	dCMP deaminase activity
C	0005737	cellular_component	cytoplasm
C	0008270	molecular_function	zinc ion binding
C	0016787	molecular_function	hydrolase activity
C	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1001

Chain	Residue
A	CYS24
A	CYS54
A	HIS59
A	CYS66

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 1002

Chain	Residue
A	HIS71
A	GLU73
A	CYS99
A	CYS102
A	DDN1301

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 1101

Chain	Residue
A	DCP1201
A	HOH1411
A	HOH1604
A	HOH1609

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1003

Chain	Residue
B	CYS24
B	CYS54
B	HIS59
B	CYS66

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 1004

Chain	Residue
B	HIS71
B	GLU73
B	CYS99
B	CYS102
B	DDN1302

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG B 1102

Chain	Residue
B	DCP1202
B	HOH1448
B	HOH1615
B	HOH1618

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 1005

Chain	Residue
C	CYS24
C	CYS54
C	HIS59
C	CYS66

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 1006

Chain	Residue
C	HIS71
C	CYS99
C	CYS102
C	DDN1303

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG C 1103

Chain	Residue
C	DCP1203
C	HOH1603
C	HOH1607
C	HOH1610

---

site_id	BC1
Number of Residues	28
Details	BINDING SITE FOR RESIDUE DCP A 1201

Chain	Residue
A	ARG4
A	TRP7
A	ARG21
A	ASN37
A	ARG38
A	GLY43
A	TYR44
A	GLY46
A	GLY47
A	ALA49
A	ASP50
A	ASN53
A	ASN75
A	MG1101
A	HOH1404
A	HOH1406
A	HOH1411
A	HOH1459
A	HOH1480
A	HOH1489
A	HOH1523
A	HOH1526
A	HOH1595
A	HOH1604
A	HOH1609
A	HOH1610
A	HOH1645
B	GLN108

---

site_id	BC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE DDN A 1301

Chain	Residue
A	CYS24
A	ARG26
A	VAL29
A	ASN45
A	HIS65
A	CYS66
A	THR69
A	HIS71
A	ALA72
A	GLU73
A	PRO98
A	CYS99
A	CYS102
A	TYR120
A	ARG121
A	ZN1002
A	HOH1414
A	HOH1431

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DIO A 1401

Chain	Residue
A	SER19
A	LYS20
A	SER22
A	TYR28
A	HOH1650
A	HOH1651

---

site_id	BC4
Number of Residues	28
Details	BINDING SITE FOR RESIDUE DCP B 1202

Chain	Residue
B	ASN75
B	MG1102
B	HOH1404
B	HOH1409
B	HOH1430
B	HOH1448
B	HOH1468
B	HOH1528
B	HOH1537
B	HOH1557
B	HOH1570
B	HOH1615
B	HOH1618
B	HOH1621
B	HOH1641
C	ARG4
C	TRP7
C	ASN37
C	ARG38
A	GLN108
B	ARG21
B	GLY43
B	TYR44
B	GLY46
B	GLY47
B	ALA49
B	ASP50
B	ASN53

---

site_id	BC5
Number of Residues	18
Details	BINDING SITE FOR RESIDUE DDN B 1302

Chain	Residue
B	CYS24
B	ARG26
B	VAL29
B	ASN45
B	HIS65
B	CYS66
B	THR69
B	HIS71
B	ALA72
B	GLU73
B	PRO98
B	CYS99
B	CYS102
B	TYR120
B	ARG121
B	ZN1004
B	HOH1405
B	HOH1478

---

site_id	BC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DIO B 1402

Chain	Residue
B	SER19
B	LYS20
B	SER22
B	TYR28
B	HOH1513
B	HOH1664
B	HOH1665

---

site_id	BC7
Number of Residues	28
Details	BINDING SITE FOR RESIDUE DCP C 1203

Chain	Residue
B	ARG4
B	TRP7
B	ASN37
B	ARG38
B	HOH1501
C	ARG21
C	GLY43
C	TYR44
C	GLY46
C	GLY47
C	ALA49
C	ASP50
C	ASN53
C	ASN75
C	GLN108
C	MG1103
C	HOH1406
C	HOH1409
C	HOH1477
C	HOH1484
C	HOH1493
C	HOH1512
C	HOH1595
C	HOH1600
C	HOH1603
C	HOH1607
C	HOH1610
C	HOH1631

---

site_id	BC8
Number of Residues	18
Details	BINDING SITE FOR RESIDUE DDN C 1303

Chain	Residue
C	CYS24
C	ARG26
C	VAL29
C	ASN45
C	HIS65
C	CYS66
C	THR69
C	HIS71
C	ALA72
C	GLU73
C	PRO98
C	CYS99
C	CYS102
C	TYR120
C	ARG121
C	ZN1006
C	HOH1443
C	HOH1620

---

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DIO C 1403

Chain	Residue
C	SER19
C	LYS20
C	SER22
C	TYR28

---

Functional Information from PROSITE/UniProt

site_id	PS00903
Number of Residues	36
Details	CYT_DCMP_DEAMINASES_1 Cytidine and deoxycytidylate deaminases zinc-binding region signature. HAEmnALiqcakegisannteiyvthf.............PCin......CtkaL

Chain	Residue	Details
A	HIS71-LEU106

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