2HVG
Crystal Structure of Adenylosuccinate Lyase from Plasmodium Vivax
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004018 | molecular_function | N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity |
| A | 0006164 | biological_process | purine nucleotide biosynthetic process |
| A | 0006188 | biological_process | IMP biosynthetic process |
| A | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| A | 0009152 | biological_process | purine ribonucleotide biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0044208 | biological_process | 'de novo' AMP biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070626 | molecular_function | (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004018 | molecular_function | N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity |
| B | 0006164 | biological_process | purine nucleotide biosynthetic process |
| B | 0006188 | biological_process | IMP biosynthetic process |
| B | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| B | 0009152 | biological_process | purine ribonucleotide biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0044208 | biological_process | 'de novo' AMP biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070626 | molecular_function | (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 A 601 |
| Chain | Residue |
| A | THR167 |
| B | GLN245 |
| A | HIS168 |
| A | SER293 |
| A | LYS299 |
| A | ASN301 |
| A | HOH614 |
| A | HOH641 |
| A | HOH705 |
| A | HOH888 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 602 |
| Chain | Residue |
| A | LYS392 |
| A | ASP398 |
| A | ALA399 |
| A | TYR400 |
| A | HOH643 |
| A | HOH776 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 603 |
| Chain | Residue |
| A | HIS313 |
| A | ASN316 |
| A | LYS320 |
| A | HOH680 |
| A | HOH841 |
| B | SER324 |
| B | LYS325 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 604 |
| Chain | Residue |
| A | LYS109 |
| A | GLN430 |
| B | ASN395 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 605 |
| Chain | Residue |
| A | HIS298 |
| A | LYS410 |
| A | VAL411 |
| A | ILE412 |
| A | HOH884 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 606 |
| Chain | Residue |
| A | HIS160 |
| A | VAL161 |
| A | ARG369 |
| A | HOH731 |
| A | HOH779 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 607 |
| Chain | Residue |
| A | LYS325 |
| B | HIS313 |
| B | ASN316 |
| B | LYS320 |
| B | HOH647 |
| B | HOH868 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 608 |
| Chain | Residue |
| B | LYS283 |
| B | ILE367 |
| B | ASP368 |
| B | ARG369 |
| B | ARG370 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 609 |
| Chain | Residue |
| A | ASN395 |
| B | LYS109 |
| B | GLN430 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 610 |
| Chain | Residue |
| B | HIS160 |
| B | VAL161 |
| B | ARG369 |
| B | HOH777 |
| B | HOH793 |
| site_id | BC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 611 |
| Chain | Residue |
| A | GLU112 |
| A | HOH669 |
| B | LYS392 |
| B | ASP398 |
| B | ALA399 |
| B | TYR400 |
| B | HOH626 |
| B | HOH766 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 612 |
| Chain | Residue |
| A | GLN245 |
| A | HOH755 |
| B | THR167 |
| B | LYS299 |
| B | ASN301 |
| B | HOH684 |
| site_id | BC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 B 613 |
| Chain | Residue |
| B | LYS356 |
Functional Information from PROSITE/UniProt
| site_id | PS00163 |
| Number of Residues | 10 |
| Details | FUMARATE_LYASES Fumarate lyases signature. GSstMpHKvN |
| Chain | Residue | Details |
| A | GLY292-ASN301 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1auw |
| Chain | Residue | Details |
| A | GLU306 | |
| A | LYS299 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1auw |
| Chain | Residue | Details |
| B | THR167 | |
| B | HIS168 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1auw |
| Chain | Residue | Details |
| B | GLU306 | |
| B | LYS299 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1auw |
| Chain | Residue | Details |
| A | THR167 | |
| A | HIS168 |
| site_id | CSA5 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1auw |
| Chain | Residue | Details |
| B | HIS168 |
| site_id | CSA6 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1auw |
| Chain | Residue | Details |
| A | HIS168 |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1auw |
| Chain | Residue | Details |
| A | GLU309 | |
| A | LYS299 |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1auw |
| Chain | Residue | Details |
| B | GLU309 | |
| B | LYS299 |
