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2HV7

Crystal structure of phosphotyrosyl phosphatase activator bound to ATPgammaS

Functional Information from GO Data
ChainGOidnamespacecontents
A0000159cellular_componentprotein phosphatase type 2A complex
A0000166molecular_functionnucleotide binding
A0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
A0004721molecular_functionphosphoprotein phosphatase activity
A0005102molecular_functionsignaling receptor binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0007052biological_processmitotic spindle organization
A0008160molecular_functionprotein tyrosine phosphatase activator activity
A0016853molecular_functionisomerase activity
A0019211molecular_functionphosphatase activator activity
A0019888molecular_functionprotein phosphatase regulator activity
A0019902molecular_functionphosphatase binding
A0034704cellular_componentcalcium channel complex
A0042803molecular_functionprotein homodimerization activity
A0043065biological_processpositive regulation of apoptotic process
A0046872molecular_functionmetal ion binding
A0051721molecular_functionprotein phosphatase 2A binding
A0070062cellular_componentextracellular exosome
A1904949cellular_componentATPase complex
B0000159cellular_componentprotein phosphatase type 2A complex
B0000166molecular_functionnucleotide binding
B0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
B0004721molecular_functionphosphoprotein phosphatase activity
B0005102molecular_functionsignaling receptor binding
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0007052biological_processmitotic spindle organization
B0008160molecular_functionprotein tyrosine phosphatase activator activity
B0016853molecular_functionisomerase activity
B0019211molecular_functionphosphatase activator activity
B0019888molecular_functionprotein phosphatase regulator activity
B0019902molecular_functionphosphatase binding
B0034704cellular_componentcalcium channel complex
B0042803molecular_functionprotein homodimerization activity
B0043065biological_processpositive regulation of apoptotic process
B0046872molecular_functionmetal ion binding
B0051721molecular_functionprotein phosphatase 2A binding
B0070062cellular_componentextracellular exosome
B1904949cellular_componentATPase complex
C0000159cellular_componentprotein phosphatase type 2A complex
C0000166molecular_functionnucleotide binding
C0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
C0004721molecular_functionphosphoprotein phosphatase activity
C0005102molecular_functionsignaling receptor binding
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0007052biological_processmitotic spindle organization
C0008160molecular_functionprotein tyrosine phosphatase activator activity
C0016853molecular_functionisomerase activity
C0019211molecular_functionphosphatase activator activity
C0019888molecular_functionprotein phosphatase regulator activity
C0019902molecular_functionphosphatase binding
C0034704cellular_componentcalcium channel complex
C0042803molecular_functionprotein homodimerization activity
C0043065biological_processpositive regulation of apoptotic process
C0046872molecular_functionmetal ion binding
C0051721molecular_functionprotein phosphatase 2A binding
C0070062cellular_componentextracellular exosome
C1904949cellular_componentATPase complex
D0000159cellular_componentprotein phosphatase type 2A complex
D0000166molecular_functionnucleotide binding
D0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
D0004721molecular_functionphosphoprotein phosphatase activity
D0005102molecular_functionsignaling receptor binding
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0007052biological_processmitotic spindle organization
D0008160molecular_functionprotein tyrosine phosphatase activator activity
D0016853molecular_functionisomerase activity
D0019211molecular_functionphosphatase activator activity
D0019888molecular_functionprotein phosphatase regulator activity
D0019902molecular_functionphosphatase binding
D0034704cellular_componentcalcium channel complex
D0042803molecular_functionprotein homodimerization activity
D0043065biological_processpositive regulation of apoptotic process
D0046872molecular_functionmetal ion binding
D0051721molecular_functionprotein phosphatase 2A binding
D0070062cellular_componentextracellular exosome
D1904949cellular_componentATPase complex
E0000159cellular_componentprotein phosphatase type 2A complex
E0000166molecular_functionnucleotide binding
E0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
E0004721molecular_functionphosphoprotein phosphatase activity
E0005102molecular_functionsignaling receptor binding
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005737cellular_componentcytoplasm
E0007052biological_processmitotic spindle organization
E0008160molecular_functionprotein tyrosine phosphatase activator activity
E0016853molecular_functionisomerase activity
E0019211molecular_functionphosphatase activator activity
E0019888molecular_functionprotein phosphatase regulator activity
E0019902molecular_functionphosphatase binding
E0034704cellular_componentcalcium channel complex
E0042803molecular_functionprotein homodimerization activity
E0043065biological_processpositive regulation of apoptotic process
E0046872molecular_functionmetal ion binding
E0051721molecular_functionprotein phosphatase 2A binding
E0070062cellular_componentextracellular exosome
E1904949cellular_componentATPase complex
F0000159cellular_componentprotein phosphatase type 2A complex
F0000166molecular_functionnucleotide binding
F0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
F0004721molecular_functionphosphoprotein phosphatase activity
F0005102molecular_functionsignaling receptor binding
F0005515molecular_functionprotein binding
F0005524molecular_functionATP binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0007052biological_processmitotic spindle organization
F0008160molecular_functionprotein tyrosine phosphatase activator activity
F0016853molecular_functionisomerase activity
F0019211molecular_functionphosphatase activator activity
F0019888molecular_functionprotein phosphatase regulator activity
F0019902molecular_functionphosphatase binding
F0034704cellular_componentcalcium channel complex
F0042803molecular_functionprotein homodimerization activity
F0043065biological_processpositive regulation of apoptotic process
F0046872molecular_functionmetal ion binding
F0051721molecular_functionprotein phosphatase 2A binding
F0070062cellular_componentextracellular exosome
F1904949cellular_componentATPase complex
G0000159cellular_componentprotein phosphatase type 2A complex
G0000166molecular_functionnucleotide binding
G0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
G0004721molecular_functionphosphoprotein phosphatase activity
G0005102molecular_functionsignaling receptor binding
G0005515molecular_functionprotein binding
G0005524molecular_functionATP binding
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005737cellular_componentcytoplasm
G0007052biological_processmitotic spindle organization
G0008160molecular_functionprotein tyrosine phosphatase activator activity
G0016853molecular_functionisomerase activity
G0019211molecular_functionphosphatase activator activity
G0019888molecular_functionprotein phosphatase regulator activity
G0019902molecular_functionphosphatase binding
G0034704cellular_componentcalcium channel complex
G0042803molecular_functionprotein homodimerization activity
G0043065biological_processpositive regulation of apoptotic process
G0046872molecular_functionmetal ion binding
G0051721molecular_functionprotein phosphatase 2A binding
G0070062cellular_componentextracellular exosome
G1904949cellular_componentATPase complex
H0000159cellular_componentprotein phosphatase type 2A complex
H0000166molecular_functionnucleotide binding
H0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
H0004721molecular_functionphosphoprotein phosphatase activity
H0005102molecular_functionsignaling receptor binding
H0005515molecular_functionprotein binding
H0005524molecular_functionATP binding
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005737cellular_componentcytoplasm
H0007052biological_processmitotic spindle organization
H0008160molecular_functionprotein tyrosine phosphatase activator activity
H0016853molecular_functionisomerase activity
H0019211molecular_functionphosphatase activator activity
H0019888molecular_functionprotein phosphatase regulator activity
H0019902molecular_functionphosphatase binding
H0034704cellular_componentcalcium channel complex
H0042803molecular_functionprotein homodimerization activity
H0043065biological_processpositive regulation of apoptotic process
H0046872molecular_functionmetal ion binding
H0051721molecular_functionprotein phosphatase 2A binding
H0070062cellular_componentextracellular exosome
H1904949cellular_componentATPase complex
Functional Information from PDB Data
site_idAC1
Number of Residues10
DetailsBINDING SITE FOR RESIDUE ADP B 324
ChainResidue
BARG148
BHIS308
BGLY152
BTHR153
BGLY154
BALA204
BGLY205
BPRO304
BVAL305
BGLN307

site_idAC2
Number of Residues12
DetailsBINDING SITE FOR RESIDUE ADP C 324
ChainResidue
BPRO231
CARG148
CGLY152
CTHR153
CGLY154
CALA204
CGLY205
CGLN207
CPRO304
CVAL305
CGLN307
CHIS308

site_idAC3
Number of Residues11
DetailsBINDING SITE FOR RESIDUE ADP E 324
ChainResidue
EARG148
EGLY152
ETHR153
EGLY154
EALA204
EGLY205
ESER206
EPRO304
EVAL305
EGLN307
EHIS308

site_idAC4
Number of Residues8
DetailsBINDING SITE FOR RESIDUE ADP G 324
ChainResidue
GARG148
GTHR153
GALA204
GGLY205
GSER206
GGLN207
GPRO304
GVAL305

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues48
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"16916641","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2HV7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues16
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"16916641","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2HV6","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

239149

PDB entries from 2025-07-23

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