Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2HV7

Crystal structure of phosphotyrosyl phosphatase activator bound to ATPgammaS

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000159	cellular_component	protein phosphatase type 2A complex
A	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
A	0004721	molecular_function	phosphoprotein phosphatase activity
A	0005102	molecular_function	signaling receptor binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0007052	biological_process	mitotic spindle organization
A	0008160	molecular_function	protein tyrosine phosphatase activator activity
A	0019211	molecular_function	phosphatase activator activity
A	0019888	molecular_function	protein phosphatase regulator activity
A	0032515	biological_process	negative regulation of phosphoprotein phosphatase activity
A	0032516	biological_process	positive regulation of phosphoprotein phosphatase activity
A	0034704	cellular_component	calcium channel complex
A	0035307	biological_process	positive regulation of protein dephosphorylation
A	0035308	biological_process	negative regulation of protein dephosphorylation
A	0042803	molecular_function	protein homodimerization activity
A	0043065	biological_process	positive regulation of apoptotic process
A	0043666	biological_process	regulation of phosphoprotein phosphatase activity
A	0046872	molecular_function	metal ion binding
A	0051721	molecular_function	protein phosphatase 2A binding
A	0070062	cellular_component	extracellular exosome
A	1904949	cellular_component	ATPase complex
B	0000159	cellular_component	protein phosphatase type 2A complex
B	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
B	0004721	molecular_function	phosphoprotein phosphatase activity
B	0005102	molecular_function	signaling receptor binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0007052	biological_process	mitotic spindle organization
B	0008160	molecular_function	protein tyrosine phosphatase activator activity
B	0019211	molecular_function	phosphatase activator activity
B	0019888	molecular_function	protein phosphatase regulator activity
B	0032515	biological_process	negative regulation of phosphoprotein phosphatase activity
B	0032516	biological_process	positive regulation of phosphoprotein phosphatase activity
B	0034704	cellular_component	calcium channel complex
B	0035307	biological_process	positive regulation of protein dephosphorylation
B	0035308	biological_process	negative regulation of protein dephosphorylation
B	0042803	molecular_function	protein homodimerization activity
B	0043065	biological_process	positive regulation of apoptotic process
B	0043666	biological_process	regulation of phosphoprotein phosphatase activity
B	0046872	molecular_function	metal ion binding
B	0051721	molecular_function	protein phosphatase 2A binding
B	0070062	cellular_component	extracellular exosome
B	1904949	cellular_component	ATPase complex
C	0000159	cellular_component	protein phosphatase type 2A complex
C	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
C	0004721	molecular_function	phosphoprotein phosphatase activity
C	0005102	molecular_function	signaling receptor binding
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0007052	biological_process	mitotic spindle organization
C	0008160	molecular_function	protein tyrosine phosphatase activator activity
C	0019211	molecular_function	phosphatase activator activity
C	0019888	molecular_function	protein phosphatase regulator activity
C	0032515	biological_process	negative regulation of phosphoprotein phosphatase activity
C	0032516	biological_process	positive regulation of phosphoprotein phosphatase activity
C	0034704	cellular_component	calcium channel complex
C	0035307	biological_process	positive regulation of protein dephosphorylation
C	0035308	biological_process	negative regulation of protein dephosphorylation
C	0042803	molecular_function	protein homodimerization activity
C	0043065	biological_process	positive regulation of apoptotic process
C	0043666	biological_process	regulation of phosphoprotein phosphatase activity
C	0046872	molecular_function	metal ion binding
C	0051721	molecular_function	protein phosphatase 2A binding
C	0070062	cellular_component	extracellular exosome
C	1904949	cellular_component	ATPase complex
D	0000159	cellular_component	protein phosphatase type 2A complex
D	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
D	0004721	molecular_function	phosphoprotein phosphatase activity
D	0005102	molecular_function	signaling receptor binding
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0007052	biological_process	mitotic spindle organization
D	0008160	molecular_function	protein tyrosine phosphatase activator activity
D	0019211	molecular_function	phosphatase activator activity
D	0019888	molecular_function	protein phosphatase regulator activity
D	0032515	biological_process	negative regulation of phosphoprotein phosphatase activity
D	0032516	biological_process	positive regulation of phosphoprotein phosphatase activity
D	0034704	cellular_component	calcium channel complex
D	0035307	biological_process	positive regulation of protein dephosphorylation
D	0035308	biological_process	negative regulation of protein dephosphorylation
D	0042803	molecular_function	protein homodimerization activity
D	0043065	biological_process	positive regulation of apoptotic process
D	0043666	biological_process	regulation of phosphoprotein phosphatase activity
D	0046872	molecular_function	metal ion binding
D	0051721	molecular_function	protein phosphatase 2A binding
D	0070062	cellular_component	extracellular exosome
D	1904949	cellular_component	ATPase complex
E	0000159	cellular_component	protein phosphatase type 2A complex
E	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
E	0004721	molecular_function	phosphoprotein phosphatase activity
E	0005102	molecular_function	signaling receptor binding
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0007052	biological_process	mitotic spindle organization
E	0008160	molecular_function	protein tyrosine phosphatase activator activity
E	0019211	molecular_function	phosphatase activator activity
E	0019888	molecular_function	protein phosphatase regulator activity
E	0032515	biological_process	negative regulation of phosphoprotein phosphatase activity
E	0032516	biological_process	positive regulation of phosphoprotein phosphatase activity
E	0034704	cellular_component	calcium channel complex
E	0035307	biological_process	positive regulation of protein dephosphorylation
E	0035308	biological_process	negative regulation of protein dephosphorylation
E	0042803	molecular_function	protein homodimerization activity
E	0043065	biological_process	positive regulation of apoptotic process
E	0043666	biological_process	regulation of phosphoprotein phosphatase activity
E	0046872	molecular_function	metal ion binding
E	0051721	molecular_function	protein phosphatase 2A binding
E	0070062	cellular_component	extracellular exosome
E	1904949	cellular_component	ATPase complex
F	0000159	cellular_component	protein phosphatase type 2A complex
F	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
F	0004721	molecular_function	phosphoprotein phosphatase activity
F	0005102	molecular_function	signaling receptor binding
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0007052	biological_process	mitotic spindle organization
F	0008160	molecular_function	protein tyrosine phosphatase activator activity
F	0019211	molecular_function	phosphatase activator activity
F	0019888	molecular_function	protein phosphatase regulator activity
F	0032515	biological_process	negative regulation of phosphoprotein phosphatase activity
F	0032516	biological_process	positive regulation of phosphoprotein phosphatase activity
F	0034704	cellular_component	calcium channel complex
F	0035307	biological_process	positive regulation of protein dephosphorylation
F	0035308	biological_process	negative regulation of protein dephosphorylation
F	0042803	molecular_function	protein homodimerization activity
F	0043065	biological_process	positive regulation of apoptotic process
F	0043666	biological_process	regulation of phosphoprotein phosphatase activity
F	0046872	molecular_function	metal ion binding
F	0051721	molecular_function	protein phosphatase 2A binding
F	0070062	cellular_component	extracellular exosome
F	1904949	cellular_component	ATPase complex
G	0000159	cellular_component	protein phosphatase type 2A complex
G	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
G	0004721	molecular_function	phosphoprotein phosphatase activity
G	0005102	molecular_function	signaling receptor binding
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0007052	biological_process	mitotic spindle organization
G	0008160	molecular_function	protein tyrosine phosphatase activator activity
G	0019211	molecular_function	phosphatase activator activity
G	0019888	molecular_function	protein phosphatase regulator activity
G	0032515	biological_process	negative regulation of phosphoprotein phosphatase activity
G	0032516	biological_process	positive regulation of phosphoprotein phosphatase activity
G	0034704	cellular_component	calcium channel complex
G	0035307	biological_process	positive regulation of protein dephosphorylation
G	0035308	biological_process	negative regulation of protein dephosphorylation
G	0042803	molecular_function	protein homodimerization activity
G	0043065	biological_process	positive regulation of apoptotic process
G	0043666	biological_process	regulation of phosphoprotein phosphatase activity
G	0046872	molecular_function	metal ion binding
G	0051721	molecular_function	protein phosphatase 2A binding
G	0070062	cellular_component	extracellular exosome
G	1904949	cellular_component	ATPase complex
H	0000159	cellular_component	protein phosphatase type 2A complex
H	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
H	0004721	molecular_function	phosphoprotein phosphatase activity
H	0005102	molecular_function	signaling receptor binding
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0007052	biological_process	mitotic spindle organization
H	0008160	molecular_function	protein tyrosine phosphatase activator activity
H	0019211	molecular_function	phosphatase activator activity
H	0019888	molecular_function	protein phosphatase regulator activity
H	0032515	biological_process	negative regulation of phosphoprotein phosphatase activity
H	0032516	biological_process	positive regulation of phosphoprotein phosphatase activity
H	0034704	cellular_component	calcium channel complex
H	0035307	biological_process	positive regulation of protein dephosphorylation
H	0035308	biological_process	negative regulation of protein dephosphorylation
H	0042803	molecular_function	protein homodimerization activity
H	0043065	biological_process	positive regulation of apoptotic process
H	0043666	biological_process	regulation of phosphoprotein phosphatase activity
H	0046872	molecular_function	metal ion binding
H	0051721	molecular_function	protein phosphatase 2A binding
H	0070062	cellular_component	extracellular exosome
H	1904949	cellular_component	ATPase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ADP B 324

Chain	Residue
B	ARG148
B	HIS308
B	GLY152
B	THR153
B	GLY154
B	ALA204
B	GLY205
B	PRO304
B	VAL305
B	GLN307

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ADP C 324

Chain	Residue
B	PRO231
C	ARG148
C	GLY152
C	THR153
C	GLY154
C	ALA204
C	GLY205
C	GLN207
C	PRO304
C	VAL305
C	GLN307
C	HIS308

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ADP E 324

Chain	Residue
E	ARG148
E	GLY152
E	THR153
E	GLY154
E	ALA204
E	GLY205
E	SER206
E	PRO304
E	VAL305
E	GLN307
E	HIS308

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ADP G 324

Chain	Residue
G	ARG148
G	THR153
G	ALA204
G	GLY205
G	SER206
G	GLN207
G	PRO304
G	VAL305

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269\|PubMed:16916641, ECO:0007744\|PDB:2HV7

Chain	Residue	Details
A	LYS183
D	LYS183
D	TYR188
D	LEU189
E	LYS183
E	TYR188
E	LEU189
F	LYS183
F	TYR188
F	LEU189
G	LYS183
A	TYR188
G	TYR188
G	LEU189
H	LYS183
H	TYR188
H	LEU189
A	LEU189
B	LYS183
B	TYR188
B	LEU189
C	LYS183
C	TYR188
C	LEU189

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269\|PubMed:16916641, ECO:0007744\|PDB:2HV6

Chain	Residue	Details
A	ALA243
E	LYS249
F	ALA243
F	LYS249
G	ALA243
G	LYS249
H	ALA243
H	LYS249
A	LYS249
B	ALA243
B	LYS249
C	ALA243
C	LYS249
D	ALA243
D	LYS249
E	ALA243

site_id	SWS_FT_FI3
Number of Residues	8
Details	MOD_RES: N-acetylalanine => ECO:0007744\|PubMed:19413330

Chain	Residue	Details
A	ALA2
B	ALA2
C	ALA2
D	ALA2
E	ALA2
F	ALA2
G	ALA2
H	ALA2

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)