2HV7

Crystal structure of phosphotyrosyl phosphatase activator bound to ATPgammaS

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000159	cellular_component	protein phosphatase type 2A complex
A	0000166	molecular_function	nucleotide binding
A	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
A	0004721	molecular_function	phosphoprotein phosphatase activity
A	0005102	molecular_function	signaling receptor binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0007052	biological_process	mitotic spindle organization
A	0008160	molecular_function	protein tyrosine phosphatase activator activity
A	0016853	molecular_function	isomerase activity
A	0019211	molecular_function	phosphatase activator activity
A	0019888	molecular_function	protein phosphatase regulator activity
A	0019902	molecular_function	phosphatase binding
A	0034704	cellular_component	calcium channel complex
A	0042803	molecular_function	protein homodimerization activity
A	0043065	biological_process	positive regulation of apoptotic process
A	0046872	molecular_function	metal ion binding
A	0051721	molecular_function	protein phosphatase 2A binding
A	0070062	cellular_component	extracellular exosome
A	1904949	cellular_component	ATPase complex
B	0000159	cellular_component	protein phosphatase type 2A complex
B	0000166	molecular_function	nucleotide binding
B	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
B	0004721	molecular_function	phosphoprotein phosphatase activity
B	0005102	molecular_function	signaling receptor binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0007052	biological_process	mitotic spindle organization
B	0008160	molecular_function	protein tyrosine phosphatase activator activity
B	0016853	molecular_function	isomerase activity
B	0019211	molecular_function	phosphatase activator activity
B	0019888	molecular_function	protein phosphatase regulator activity
B	0019902	molecular_function	phosphatase binding
B	0034704	cellular_component	calcium channel complex
B	0042803	molecular_function	protein homodimerization activity
B	0043065	biological_process	positive regulation of apoptotic process
B	0046872	molecular_function	metal ion binding
B	0051721	molecular_function	protein phosphatase 2A binding
B	0070062	cellular_component	extracellular exosome
B	1904949	cellular_component	ATPase complex
C	0000159	cellular_component	protein phosphatase type 2A complex
C	0000166	molecular_function	nucleotide binding
C	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
C	0004721	molecular_function	phosphoprotein phosphatase activity
C	0005102	molecular_function	signaling receptor binding
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0007052	biological_process	mitotic spindle organization
C	0008160	molecular_function	protein tyrosine phosphatase activator activity
C	0016853	molecular_function	isomerase activity
C	0019211	molecular_function	phosphatase activator activity
C	0019888	molecular_function	protein phosphatase regulator activity
C	0019902	molecular_function	phosphatase binding
C	0034704	cellular_component	calcium channel complex
C	0042803	molecular_function	protein homodimerization activity
C	0043065	biological_process	positive regulation of apoptotic process
C	0046872	molecular_function	metal ion binding
C	0051721	molecular_function	protein phosphatase 2A binding
C	0070062	cellular_component	extracellular exosome
C	1904949	cellular_component	ATPase complex
D	0000159	cellular_component	protein phosphatase type 2A complex
D	0000166	molecular_function	nucleotide binding
D	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
D	0004721	molecular_function	phosphoprotein phosphatase activity
D	0005102	molecular_function	signaling receptor binding
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0007052	biological_process	mitotic spindle organization
D	0008160	molecular_function	protein tyrosine phosphatase activator activity
D	0016853	molecular_function	isomerase activity
D	0019211	molecular_function	phosphatase activator activity
D	0019888	molecular_function	protein phosphatase regulator activity
D	0019902	molecular_function	phosphatase binding
D	0034704	cellular_component	calcium channel complex
D	0042803	molecular_function	protein homodimerization activity
D	0043065	biological_process	positive regulation of apoptotic process
D	0046872	molecular_function	metal ion binding
D	0051721	molecular_function	protein phosphatase 2A binding
D	0070062	cellular_component	extracellular exosome
D	1904949	cellular_component	ATPase complex
E	0000159	cellular_component	protein phosphatase type 2A complex
E	0000166	molecular_function	nucleotide binding
E	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
E	0004721	molecular_function	phosphoprotein phosphatase activity
E	0005102	molecular_function	signaling receptor binding
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0007052	biological_process	mitotic spindle organization
E	0008160	molecular_function	protein tyrosine phosphatase activator activity
E	0016853	molecular_function	isomerase activity
E	0019211	molecular_function	phosphatase activator activity
E	0019888	molecular_function	protein phosphatase regulator activity
E	0019902	molecular_function	phosphatase binding
E	0034704	cellular_component	calcium channel complex
E	0042803	molecular_function	protein homodimerization activity
E	0043065	biological_process	positive regulation of apoptotic process
E	0046872	molecular_function	metal ion binding
E	0051721	molecular_function	protein phosphatase 2A binding
E	0070062	cellular_component	extracellular exosome
E	1904949	cellular_component	ATPase complex
F	0000159	cellular_component	protein phosphatase type 2A complex
F	0000166	molecular_function	nucleotide binding
F	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
F	0004721	molecular_function	phosphoprotein phosphatase activity
F	0005102	molecular_function	signaling receptor binding
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0007052	biological_process	mitotic spindle organization
F	0008160	molecular_function	protein tyrosine phosphatase activator activity
F	0016853	molecular_function	isomerase activity
F	0019211	molecular_function	phosphatase activator activity
F	0019888	molecular_function	protein phosphatase regulator activity
F	0019902	molecular_function	phosphatase binding
F	0034704	cellular_component	calcium channel complex
F	0042803	molecular_function	protein homodimerization activity
F	0043065	biological_process	positive regulation of apoptotic process
F	0046872	molecular_function	metal ion binding
F	0051721	molecular_function	protein phosphatase 2A binding
F	0070062	cellular_component	extracellular exosome
F	1904949	cellular_component	ATPase complex
G	0000159	cellular_component	protein phosphatase type 2A complex
G	0000166	molecular_function	nucleotide binding
G	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
G	0004721	molecular_function	phosphoprotein phosphatase activity
G	0005102	molecular_function	signaling receptor binding
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0007052	biological_process	mitotic spindle organization
G	0008160	molecular_function	protein tyrosine phosphatase activator activity
G	0016853	molecular_function	isomerase activity
G	0019211	molecular_function	phosphatase activator activity
G	0019888	molecular_function	protein phosphatase regulator activity
G	0019902	molecular_function	phosphatase binding
G	0034704	cellular_component	calcium channel complex
G	0042803	molecular_function	protein homodimerization activity
G	0043065	biological_process	positive regulation of apoptotic process
G	0046872	molecular_function	metal ion binding
G	0051721	molecular_function	protein phosphatase 2A binding
G	0070062	cellular_component	extracellular exosome
G	1904949	cellular_component	ATPase complex
H	0000159	cellular_component	protein phosphatase type 2A complex
H	0000166	molecular_function	nucleotide binding
H	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
H	0004721	molecular_function	phosphoprotein phosphatase activity
H	0005102	molecular_function	signaling receptor binding
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0007052	biological_process	mitotic spindle organization
H	0008160	molecular_function	protein tyrosine phosphatase activator activity
H	0016853	molecular_function	isomerase activity
H	0019211	molecular_function	phosphatase activator activity
H	0019888	molecular_function	protein phosphatase regulator activity
H	0019902	molecular_function	phosphatase binding
H	0034704	cellular_component	calcium channel complex
H	0042803	molecular_function	protein homodimerization activity
H	0043065	biological_process	positive regulation of apoptotic process
H	0046872	molecular_function	metal ion binding
H	0051721	molecular_function	protein phosphatase 2A binding
H	0070062	cellular_component	extracellular exosome
H	1904949	cellular_component	ATPase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ADP B 324

Chain	Residue
B	ARG148
B	HIS308
B	GLY152
B	THR153
B	GLY154
B	ALA204
B	GLY205
B	PRO304
B	VAL305
B	GLN307

---

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ADP C 324

Chain	Residue
B	PRO231
C	ARG148
C	GLY152
C	THR153
C	GLY154
C	ALA204
C	GLY205
C	GLN207
C	PRO304
C	VAL305
C	GLN307
C	HIS308

---

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ADP E 324

Chain	Residue
E	ARG148
E	GLY152
E	THR153
E	GLY154
E	ALA204
E	GLY205
E	SER206
E	PRO304
E	VAL305
E	GLN307
E	HIS308

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ADP G 324

Chain	Residue
G	ARG148
G	THR153
G	ALA204
G	GLY205
G	SER206
G	GLN207
G	PRO304
G	VAL305

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16916641","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2HV7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16916641","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2HV6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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