2HV6

Crystal structure of the phosphotyrosyl phosphatase activator

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000159	cellular_component	protein phosphatase type 2A complex
A	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
A	0004721	molecular_function	phosphoprotein phosphatase activity
A	0005102	molecular_function	signaling receptor binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0007052	biological_process	mitotic spindle organization
A	0008160	molecular_function	protein tyrosine phosphatase activator activity
A	0019211	molecular_function	phosphatase activator activity
A	0019888	molecular_function	protein phosphatase regulator activity
A	0019902	molecular_function	phosphatase binding
A	0034704	cellular_component	calcium channel complex
A	0042803	molecular_function	protein homodimerization activity
A	0043065	biological_process	positive regulation of apoptotic process
A	0046872	molecular_function	metal ion binding
A	0051721	molecular_function	protein phosphatase 2A binding
A	0070062	cellular_component	extracellular exosome
A	1904949	cellular_component	ATPase complex
B	0000159	cellular_component	protein phosphatase type 2A complex
B	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
B	0004721	molecular_function	phosphoprotein phosphatase activity
B	0005102	molecular_function	signaling receptor binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0007052	biological_process	mitotic spindle organization
B	0008160	molecular_function	protein tyrosine phosphatase activator activity
B	0019211	molecular_function	phosphatase activator activity
B	0019888	molecular_function	protein phosphatase regulator activity
B	0019902	molecular_function	phosphatase binding
B	0034704	cellular_component	calcium channel complex
B	0042803	molecular_function	protein homodimerization activity
B	0043065	biological_process	positive regulation of apoptotic process
B	0046872	molecular_function	metal ion binding
B	0051721	molecular_function	protein phosphatase 2A binding
B	0070062	cellular_component	extracellular exosome
B	1904949	cellular_component	ATPase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 324

Chain	Residue
A	GLY208
A	ASP214
A	HOH363
A	HOH365
A	HOH388

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:16916641, ECO:0007744|PDB:2HV7

Chain	Residue	Details
A	LYS183
A	TYR188
A	LEU189
B	LYS183
B	TYR188
B	LEU189

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:16916641, ECO:0007744|PDB:2HV6

Chain	Residue	Details
A	ALA243
A	LYS249
B	ALA243
B	LYS249

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330

Chain	Residue	Details
A	ALA2
B	ALA2

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