2HUU
Crystal structure of Aedes aegypti alanine glyoxylate aminotransferase in complex with alanine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004760 | molecular_function | L-serine-pyruvate transaminase activity |
| A | 0005777 | cellular_component | peroxisome |
| A | 0008453 | molecular_function | alanine-glyoxylate transaminase activity |
| A | 0008483 | molecular_function | transaminase activity |
| A | 0009436 | biological_process | glyoxylate catabolic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019265 | biological_process | glycine biosynthetic process, by transamination of glyoxylate |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0004760 | molecular_function | L-serine-pyruvate transaminase activity |
| B | 0005777 | cellular_component | peroxisome |
| B | 0008453 | molecular_function | alanine-glyoxylate transaminase activity |
| B | 0008483 | molecular_function | transaminase activity |
| B | 0009436 | biological_process | glyoxylate catabolic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0019265 | biological_process | glycine biosynthetic process, by transamination of glyoxylate |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ALA A 701 |
| Chain | Residue |
| A | PRO25 |
| A | SER155 |
| A | LLP206 |
| A | LEU347 |
| A | ARG356 |
| B | HIS45 |
| B | TYR257 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE 1BO B 801 |
| Chain | Residue |
| B | PRO25 |
| B | SER155 |
| B | ARG356 |
| B | HOH1082 |
| B | HOH1111 |
| A | HIS45 |
| A | TYR257 |
Functional Information from PROSITE/UniProt
| site_id | PS00595 |
| Number of Residues | 21 |
| Details | AA_TRANSFER_CLASS_5 Aminotransferases class-V pyridoxal-phosphate attachment site. IDAMytGSQKvlgappGiTpV |
| Chain | Residue | Details |
| A | ILE197-VAL217 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Binding site: {"description":"in other chain","evidences":[{"source":"PubMed","id":"16990263","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2HUF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HUI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HUU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16990263","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2HUU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"in other chain","evidences":[{"source":"PubMed","id":"16990263","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2HUI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HUU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16990263","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2HUI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HUU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16990263","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2HUI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"source":"PIRSR","id":"PIRSR000524-50","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16990263","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2HUI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HUU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1bjo |
| Chain | Residue | Details |
| A | LEU51 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1bjo |
| Chain | Residue | Details |
| B | LEU51 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1bjo |
| Chain | Residue | Details |
| A | ASP180 | |
| A | TRP105 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1bjo |
| Chain | Residue | Details |
| B | ASP180 | |
| B | TRP105 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1bjo |
| Chain | Residue | Details |
| A | HIS104 | |
| A | ASP180 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1bjo |
| Chain | Residue | Details |
| B | HIS104 | |
| B | ASP180 |
