2HUR
Escherichia coli nucleoside diphosphate kinase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006183 | biological_process | GTP biosynthetic process |
| A | 0006228 | biological_process | UTP biosynthetic process |
| A | 0006241 | biological_process | CTP biosynthetic process |
| A | 0009142 | biological_process | nucleoside triphosphate biosynthetic process |
| B | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006183 | biological_process | GTP biosynthetic process |
| B | 0006228 | biological_process | UTP biosynthetic process |
| B | 0006241 | biological_process | CTP biosynthetic process |
| B | 0009142 | biological_process | nucleoside triphosphate biosynthetic process |
| C | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006183 | biological_process | GTP biosynthetic process |
| C | 0006228 | biological_process | UTP biosynthetic process |
| C | 0006241 | biological_process | CTP biosynthetic process |
| C | 0009142 | biological_process | nucleoside triphosphate biosynthetic process |
| D | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006183 | biological_process | GTP biosynthetic process |
| D | 0006228 | biological_process | UTP biosynthetic process |
| D | 0006241 | biological_process | CTP biosynthetic process |
| D | 0009142 | biological_process | nucleoside triphosphate biosynthetic process |
| E | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
| E | 0005515 | molecular_function | protein binding |
| E | 0005524 | molecular_function | ATP binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0006183 | biological_process | GTP biosynthetic process |
| E | 0006228 | biological_process | UTP biosynthetic process |
| E | 0006241 | biological_process | CTP biosynthetic process |
| E | 0009142 | biological_process | nucleoside triphosphate biosynthetic process |
| F | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
| F | 0005515 | molecular_function | protein binding |
| F | 0005524 | molecular_function | ATP binding |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0006183 | biological_process | GTP biosynthetic process |
| F | 0006228 | biological_process | UTP biosynthetic process |
| F | 0006241 | biological_process | CTP biosynthetic process |
| F | 0009142 | biological_process | nucleoside triphosphate biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 200 |
| Chain | Residue |
| A | LYS11 |
| A | THR93 |
| A | ARG104 |
| A | ASN114 |
| A | HIS117 |
| A | HOH226 |
| A | HOH237 |
| A | HOH264 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 200 |
| Chain | Residue |
| B | THR93 |
| B | ARG104 |
| B | ASN114 |
| B | HIS117 |
| B | HOH246 |
| B | HOH276 |
| B | HOH322 |
| B | LYS11 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 C 200 |
| Chain | Residue |
| C | LYS11 |
| C | THR93 |
| C | ARG104 |
| C | ASN114 |
| C | HIS117 |
| C | HOH247 |
| C | HOH258 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SO4 D 200 |
| Chain | Residue |
| D | LYS11 |
| D | THR93 |
| D | ARG104 |
| D | ASN114 |
| D | HIS117 |
| D | HOH327 |
| D | HOH334 |
| D | HOH397 |
| D | HOH408 |
| D | HOH443 |
| F | HOH360 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 E 200 |
| Chain | Residue |
| E | LYS11 |
| E | THR93 |
| E | ARG104 |
| E | ASN114 |
| E | HIS117 |
| E | HOH287 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SO4 F 200 |
| Chain | Residue |
| D | HOH343 |
| F | LYS11 |
| F | THR93 |
| F | ARG104 |
| F | ASN114 |
| F | HIS117 |
| F | HOH290 |
| F | HOH302 |
| F | HOH329 |
| F | HOH332 |
| F | HOH344 |
Functional Information from PROSITE/UniProt
| site_id | PS00469 |
| Number of Residues | 9 |
| Details | NDPK Nucleoside diphosphate kinase (NDPK) active site signature. NgtHGSDSV |
| Chain | Residue | Details |
| A | ASN114-VAL122 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Active site: {"description":"Pros-phosphohistidine intermediate","evidences":[{"source":"UniProtKB","id":"P15531","evidenceCode":"ECO:0000250"},{"source":"HAMAP-Rule","id":"MF_00451","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 36 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00451","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"7730286","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1nsp |
| Chain | Residue | Details |
| A | ASN114 | |
| A | LYS11 |
| site_id | CSA10 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1nsp |
| Chain | Residue | Details |
| D | TYR51 | |
| D | LYS11 |
| site_id | CSA11 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1nsp |
| Chain | Residue | Details |
| E | TYR51 | |
| E | LYS11 |
| site_id | CSA12 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1nsp |
| Chain | Residue | Details |
| F | TYR51 | |
| F | LYS11 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1nsp |
| Chain | Residue | Details |
| B | ASN114 | |
| B | LYS11 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1nsp |
| Chain | Residue | Details |
| C | ASN114 | |
| C | LYS11 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1nsp |
| Chain | Residue | Details |
| D | ASN114 | |
| D | LYS11 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1nsp |
| Chain | Residue | Details |
| E | ASN114 | |
| E | LYS11 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1nsp |
| Chain | Residue | Details |
| F | ASN114 | |
| F | LYS11 |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1nsp |
| Chain | Residue | Details |
| A | TYR51 | |
| A | LYS11 |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1nsp |
| Chain | Residue | Details |
| B | TYR51 | |
| B | LYS11 |
| site_id | CSA9 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1nsp |
| Chain | Residue | Details |
| C | TYR51 | |
| C | LYS11 |
