2HUR

Escherichia coli nucleoside diphosphate kinase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004550	molecular_function	nucleoside diphosphate kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006163	biological_process	purine nucleotide metabolic process
A	0006183	biological_process	GTP biosynthetic process
A	0006220	biological_process	pyrimidine nucleotide metabolic process
A	0006228	biological_process	UTP biosynthetic process
A	0006241	biological_process	CTP biosynthetic process
A	0009117	biological_process	nucleotide metabolic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0004550	molecular_function	nucleoside diphosphate kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006163	biological_process	purine nucleotide metabolic process
B	0006183	biological_process	GTP biosynthetic process
B	0006220	biological_process	pyrimidine nucleotide metabolic process
B	0006228	biological_process	UTP biosynthetic process
B	0006241	biological_process	CTP biosynthetic process
B	0009117	biological_process	nucleotide metabolic process
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0046872	molecular_function	metal ion binding
C	0000166	molecular_function	nucleotide binding
C	0004550	molecular_function	nucleoside diphosphate kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006163	biological_process	purine nucleotide metabolic process
C	0006183	biological_process	GTP biosynthetic process
C	0006220	biological_process	pyrimidine nucleotide metabolic process
C	0006228	biological_process	UTP biosynthetic process
C	0006241	biological_process	CTP biosynthetic process
C	0009117	biological_process	nucleotide metabolic process
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0046872	molecular_function	metal ion binding
D	0000166	molecular_function	nucleotide binding
D	0004550	molecular_function	nucleoside diphosphate kinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006163	biological_process	purine nucleotide metabolic process
D	0006183	biological_process	GTP biosynthetic process
D	0006220	biological_process	pyrimidine nucleotide metabolic process
D	0006228	biological_process	UTP biosynthetic process
D	0006241	biological_process	CTP biosynthetic process
D	0009117	biological_process	nucleotide metabolic process
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0046872	molecular_function	metal ion binding
E	0000166	molecular_function	nucleotide binding
E	0004550	molecular_function	nucleoside diphosphate kinase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006163	biological_process	purine nucleotide metabolic process
E	0006183	biological_process	GTP biosynthetic process
E	0006220	biological_process	pyrimidine nucleotide metabolic process
E	0006228	biological_process	UTP biosynthetic process
E	0006241	biological_process	CTP biosynthetic process
E	0009117	biological_process	nucleotide metabolic process
E	0016301	molecular_function	kinase activity
E	0016740	molecular_function	transferase activity
E	0046872	molecular_function	metal ion binding
F	0000166	molecular_function	nucleotide binding
F	0004550	molecular_function	nucleoside diphosphate kinase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006163	biological_process	purine nucleotide metabolic process
F	0006183	biological_process	GTP biosynthetic process
F	0006220	biological_process	pyrimidine nucleotide metabolic process
F	0006228	biological_process	UTP biosynthetic process
F	0006241	biological_process	CTP biosynthetic process
F	0009117	biological_process	nucleotide metabolic process
F	0016301	molecular_function	kinase activity
F	0016740	molecular_function	transferase activity
F	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 200

Chain	Residue
A	LYS11
A	THR93
A	ARG104
A	ASN114
A	HIS117
A	HOH226
A	HOH237
A	HOH264

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 B 200

Chain	Residue
B	THR93
B	ARG104
B	ASN114
B	HIS117
B	HOH246
B	HOH276
B	HOH322
B	LYS11

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 C 200

Chain	Residue
C	LYS11
C	THR93
C	ARG104
C	ASN114
C	HIS117
C	HOH247
C	HOH258

---

site_id	AC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE SO4 D 200

Chain	Residue
D	LYS11
D	THR93
D	ARG104
D	ASN114
D	HIS117
D	HOH327
D	HOH334
D	HOH397
D	HOH408
D	HOH443
F	HOH360

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 E 200

Chain	Residue
E	LYS11
E	THR93
E	ARG104
E	ASN114
E	HIS117
E	HOH287

---

site_id	AC6
Number of Residues	11
Details	BINDING SITE FOR RESIDUE SO4 F 200

Chain	Residue
D	HOH343
F	LYS11
F	THR93
F	ARG104
F	ASN114
F	HIS117
F	HOH290
F	HOH302
F	HOH329
F	HOH332
F	HOH344

---

Functional Information from PROSITE/UniProt

site_id	PS00469
Number of Residues	9
Details	NDPK Nucleoside diphosphate kinase (NDPK) active site signature. NgtHGSDSV

Chain	Residue	Details
A	ASN114-VAL122

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Active site: {"description":"Pros-phosphohistidine intermediate","evidences":[{"source":"UniProtKB","id":"P15531","evidenceCode":"ECO:0000250"},{"source":"HAMAP-Rule","id":"MF_00451","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00451","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"7730286","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1nsp

Chain	Residue	Details
A	ASN114
A	LYS11

---

site_id	CSA10
Number of Residues	2
Details	Annotated By Reference To The Literature 1nsp

Chain	Residue	Details
D	TYR51
D	LYS11

---

site_id	CSA11
Number of Residues	2
Details	Annotated By Reference To The Literature 1nsp

Chain	Residue	Details
E	TYR51
E	LYS11

---

site_id	CSA12
Number of Residues	2
Details	Annotated By Reference To The Literature 1nsp

Chain	Residue	Details
F	TYR51
F	LYS11

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1nsp

Chain	Residue	Details
B	ASN114
B	LYS11

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1nsp

Chain	Residue	Details
C	ASN114
C	LYS11

---

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1nsp

Chain	Residue	Details
D	ASN114
D	LYS11

---

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1nsp

Chain	Residue	Details
E	ASN114
E	LYS11

---

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1nsp

Chain	Residue	Details
F	ASN114
F	LYS11

---

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1nsp

Chain	Residue	Details
A	TYR51
A	LYS11

---

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1nsp

Chain	Residue	Details
B	TYR51
B	LYS11

---

site_id	CSA9
Number of Residues	2
Details	Annotated By Reference To The Literature 1nsp

Chain	Residue	Details
C	TYR51
C	LYS11

---