2HUR
Escherichia coli nucleoside diphosphate kinase
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005524 | molecular_function | ATP binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006163 | biological_process | purine nucleotide metabolic process |
A | 0006183 | biological_process | GTP biosynthetic process |
A | 0006220 | biological_process | pyrimidine nucleotide metabolic process |
A | 0006228 | biological_process | UTP biosynthetic process |
A | 0006241 | biological_process | CTP biosynthetic process |
A | 0009117 | biological_process | nucleotide metabolic process |
A | 0016301 | molecular_function | kinase activity |
A | 0016310 | biological_process | phosphorylation |
A | 0046872 | molecular_function | metal ion binding |
B | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005524 | molecular_function | ATP binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006163 | biological_process | purine nucleotide metabolic process |
B | 0006183 | biological_process | GTP biosynthetic process |
B | 0006220 | biological_process | pyrimidine nucleotide metabolic process |
B | 0006228 | biological_process | UTP biosynthetic process |
B | 0006241 | biological_process | CTP biosynthetic process |
B | 0009117 | biological_process | nucleotide metabolic process |
B | 0016301 | molecular_function | kinase activity |
B | 0016310 | biological_process | phosphorylation |
B | 0046872 | molecular_function | metal ion binding |
C | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
C | 0005515 | molecular_function | protein binding |
C | 0005524 | molecular_function | ATP binding |
C | 0005737 | cellular_component | cytoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0006163 | biological_process | purine nucleotide metabolic process |
C | 0006183 | biological_process | GTP biosynthetic process |
C | 0006220 | biological_process | pyrimidine nucleotide metabolic process |
C | 0006228 | biological_process | UTP biosynthetic process |
C | 0006241 | biological_process | CTP biosynthetic process |
C | 0009117 | biological_process | nucleotide metabolic process |
C | 0016301 | molecular_function | kinase activity |
C | 0016310 | biological_process | phosphorylation |
C | 0046872 | molecular_function | metal ion binding |
D | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
D | 0005515 | molecular_function | protein binding |
D | 0005524 | molecular_function | ATP binding |
D | 0005737 | cellular_component | cytoplasm |
D | 0005829 | cellular_component | cytosol |
D | 0006163 | biological_process | purine nucleotide metabolic process |
D | 0006183 | biological_process | GTP biosynthetic process |
D | 0006220 | biological_process | pyrimidine nucleotide metabolic process |
D | 0006228 | biological_process | UTP biosynthetic process |
D | 0006241 | biological_process | CTP biosynthetic process |
D | 0009117 | biological_process | nucleotide metabolic process |
D | 0016301 | molecular_function | kinase activity |
D | 0016310 | biological_process | phosphorylation |
D | 0046872 | molecular_function | metal ion binding |
E | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
E | 0005515 | molecular_function | protein binding |
E | 0005524 | molecular_function | ATP binding |
E | 0005737 | cellular_component | cytoplasm |
E | 0005829 | cellular_component | cytosol |
E | 0006163 | biological_process | purine nucleotide metabolic process |
E | 0006183 | biological_process | GTP biosynthetic process |
E | 0006220 | biological_process | pyrimidine nucleotide metabolic process |
E | 0006228 | biological_process | UTP biosynthetic process |
E | 0006241 | biological_process | CTP biosynthetic process |
E | 0009117 | biological_process | nucleotide metabolic process |
E | 0016301 | molecular_function | kinase activity |
E | 0016310 | biological_process | phosphorylation |
E | 0046872 | molecular_function | metal ion binding |
F | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
F | 0005515 | molecular_function | protein binding |
F | 0005524 | molecular_function | ATP binding |
F | 0005737 | cellular_component | cytoplasm |
F | 0005829 | cellular_component | cytosol |
F | 0006163 | biological_process | purine nucleotide metabolic process |
F | 0006183 | biological_process | GTP biosynthetic process |
F | 0006220 | biological_process | pyrimidine nucleotide metabolic process |
F | 0006228 | biological_process | UTP biosynthetic process |
F | 0006241 | biological_process | CTP biosynthetic process |
F | 0009117 | biological_process | nucleotide metabolic process |
F | 0016301 | molecular_function | kinase activity |
F | 0016310 | biological_process | phosphorylation |
F | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE SO4 A 200 |
Chain | Residue |
A | LYS11 |
A | THR93 |
A | ARG104 |
A | ASN114 |
A | HIS117 |
A | HOH226 |
A | HOH237 |
A | HOH264 |
site_id | AC2 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE SO4 B 200 |
Chain | Residue |
B | THR93 |
B | ARG104 |
B | ASN114 |
B | HIS117 |
B | HOH246 |
B | HOH276 |
B | HOH322 |
B | LYS11 |
site_id | AC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE SO4 C 200 |
Chain | Residue |
C | LYS11 |
C | THR93 |
C | ARG104 |
C | ASN114 |
C | HIS117 |
C | HOH247 |
C | HOH258 |
site_id | AC4 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE SO4 D 200 |
Chain | Residue |
D | LYS11 |
D | THR93 |
D | ARG104 |
D | ASN114 |
D | HIS117 |
D | HOH327 |
D | HOH334 |
D | HOH397 |
D | HOH408 |
D | HOH443 |
F | HOH360 |
site_id | AC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 E 200 |
Chain | Residue |
E | LYS11 |
E | THR93 |
E | ARG104 |
E | ASN114 |
E | HIS117 |
E | HOH287 |
site_id | AC6 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE SO4 F 200 |
Chain | Residue |
D | HOH343 |
F | LYS11 |
F | THR93 |
F | ARG104 |
F | ASN114 |
F | HIS117 |
F | HOH290 |
F | HOH302 |
F | HOH329 |
F | HOH332 |
F | HOH344 |
Functional Information from PROSITE/UniProt
site_id | PS00469 |
Number of Residues | 9 |
Details | NDPK Nucleoside diphosphate kinase (NDPK) active site signature. NgtHGSDSV |
Chain | Residue | Details |
A | ASN114-VAL122 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 6 |
Details | ACT_SITE: Pros-phosphohistidine intermediate => ECO:0000250|UniProtKB:P15531, ECO:0000255|HAMAP-Rule:MF_00451 |
Chain | Residue | Details |
A | GLY118 | |
B | GLY118 | |
C | GLY118 | |
D | GLY118 | |
E | GLY118 | |
F | GLY118 |
site_id | SWS_FT_FI2 |
Number of Residues | 36 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00451 |
Chain | Residue | Details |
A | PRO12 | |
B | ASN94 | |
B | ALA105 | |
B | GLY115 | |
C | PRO12 | |
C | PHE60 | |
C | ASP88 | |
C | ASN94 | |
C | ALA105 | |
C | GLY115 | |
D | PRO12 | |
A | PHE60 | |
D | PHE60 | |
D | ASP88 | |
D | ASN94 | |
D | ALA105 | |
D | GLY115 | |
E | PRO12 | |
E | PHE60 | |
E | ASP88 | |
E | ASN94 | |
E | ALA105 | |
A | ASP88 | |
E | GLY115 | |
F | PRO12 | |
F | PHE60 | |
F | ASP88 | |
F | ASN94 | |
F | ALA105 | |
F | GLY115 | |
A | ASN94 | |
A | ALA105 | |
A | GLY115 | |
B | PRO12 | |
B | PHE60 | |
B | ASP88 |
site_id | SWS_FT_FI3 |
Number of Residues | 12 |
Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:7730286 |
Chain | Residue | Details |
A | ASP120 | |
E | VAL122 | |
F | ASP120 | |
F | VAL122 | |
A | VAL122 | |
B | ASP120 | |
B | VAL122 | |
C | ASP120 | |
C | VAL122 | |
D | ASP120 | |
D | VAL122 | |
E | ASP120 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1nsp |
Chain | Residue | Details |
A | ASN114 | |
A | LYS11 |
site_id | CSA10 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1nsp |
Chain | Residue | Details |
D | TYR51 | |
D | LYS11 |
site_id | CSA11 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1nsp |
Chain | Residue | Details |
E | TYR51 | |
E | LYS11 |
site_id | CSA12 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1nsp |
Chain | Residue | Details |
F | TYR51 | |
F | LYS11 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1nsp |
Chain | Residue | Details |
B | ASN114 | |
B | LYS11 |
site_id | CSA3 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1nsp |
Chain | Residue | Details |
C | ASN114 | |
C | LYS11 |
site_id | CSA4 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1nsp |
Chain | Residue | Details |
D | ASN114 | |
D | LYS11 |
site_id | CSA5 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1nsp |
Chain | Residue | Details |
E | ASN114 | |
E | LYS11 |
site_id | CSA6 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1nsp |
Chain | Residue | Details |
F | ASN114 | |
F | LYS11 |
site_id | CSA7 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1nsp |
Chain | Residue | Details |
A | TYR51 | |
A | LYS11 |
site_id | CSA8 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1nsp |
Chain | Residue | Details |
B | TYR51 | |
B | LYS11 |
site_id | CSA9 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1nsp |
Chain | Residue | Details |
C | TYR51 | |
C | LYS11 |