2HU3

Parent Structure of Hen Egg White Lysozyme grown in acidic pH 4.8. Refinement for comparison with crosslinked molecules of lysozyme

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003796	molecular_function	lysozyme activity
A	0003824	molecular_function	catalytic activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0008152	biological_process	metabolic process
A	0016231	molecular_function	beta-N-acetylglucosaminidase activity
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0016998	biological_process	cell wall macromolecule catabolic process
A	0031640	biological_process	killing of cells of another organism
A	0042742	biological_process	defense response to bacterium
A	0042802	molecular_function	identical protein binding
A	0050829	biological_process	defense response to Gram-negative bacterium
A	0050830	biological_process	defense response to Gram-positive bacterium
A	0051672	biological_process	obsolete catabolism by organism of cell wall peptidoglycan in other organism

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 5001

Chain	Residue
A	TYR23
A	ASN113

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL A 5002

Chain	Residue
A	GLY67
A	ARG68
A	THR69
A	SER72
A	CL5006
A	CL5012

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 5003

Chain	Residue
A	GLY26
A	GLN121
A	HOH9069
A	SER24

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 5004

Chain	Residue
A	ALA42
A	ASN44
A	ARG68
A	HOH9066

---

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 5005

Chain	Residue
A	LYS33

---

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CL A 5006

Chain	Residue
A	SER60
A	CYS64
A	ASN65
A	ASP66
A	THR69
A	SER72
A	CL5002
A	NA9002
A	HOH9028

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 5007

Chain	Residue
A	ASN65
A	PRO79
A	HOH9043

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 5008

Chain	Residue
A	ILE88
A	HOH9155

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 5009

Chain	Residue
A	TRP111
A	ARG114
A	HOH9045
A	HOH9059

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 5010

Chain	Residue
A	ARG73
A	ASN74
A	HOH9206

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 5011

Chain	Residue
A	ARG5
A	CYS6
A	HOH9007
A	HOH9146

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 5012

Chain	Residue
A	PRO70
A	GLY71
A	CL5002
A	HOH9107
A	HOH9222

---

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 9001

Chain	Residue
A	GLY49
A	SER50
A	THR51
A	ASP66
A	ARG68
A	THR69

---

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 9002

Chain	Residue
A	SER60
A	CYS64
A	SER72
A	ARG73
A	CL5006
A	HOH9028

---

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA A 9003

Chain	Residue
A	ASN65
A	GLY67
A	HOH9201
A	HOH9223

---

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA A 9004

Chain	Residue
A	GLN41
A	THR43
A	TYR53
A	ARG68

---

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 9005

Chain	Residue
A	ALA82
A	ASP87
A	ILE88
A	ALA90
A	SER91
A	HOH9006

---

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NH4 A 7001

Chain	Residue
A	ASP48
A	SER50
A	ASN59
A	HOH9219

---

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NH4 A 7003

Chain	Residue
A	ASP18
A	HOH9158
A	HOH9177
A	HOH9233

---

site_id	CC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 1001

Chain	Residue
A	ILE58
A	ASN59
A	TRP63
A	ALA107
A	TRP108
A	HOH9010
A	HOH9036
A	HOH9070

---

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1002

Chain	Residue
A	ARG61
A	TRP62
A	GLY71
A	ARG73
A	HOH9218

---

site_id	CC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 1003

Chain	Residue
A	HOH9193
A	HOH9193
A	ALA10
A	ALA11
A	ALA11
A	HOH9031
A	HOH9031

---

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1006

Chain	Residue
A	TRP123
A	HOH9057
A	HOH9091
A	HOH9145

---

site_id	CC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 2001

Chain	Residue
A	THR43
A	THR43
A	ASN44
A	ARG45
A	ARG45
A	HOH9232
A	HOH9236
A	HOH9236

---

Functional Information from PROSITE/UniProt

site_id	PS00128
Number of Residues	19
Details	GLYCOSYL_HYDROL_F22_1 Glycosyl hydrolases family 22 (GH22) domain signature. CnipCsaLlssDItasvnC

Chain	Residue	Details
A	CYS76-CYS94

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE:

Chain	Residue	Details
A	GLU35
A	ASP52

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING:

Chain	Residue	Details
A	ASP101

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	6
Details	M-CSA 203

Chain	Residue	Details
A	GLU35	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
A	ASN46
A	ASP48
A	SER50
A	ASP52	covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, polar/non-polar interaction
A	ASN59

---