Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003714 | molecular_function | transcription corepressor activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE NAD A 600 |
| Chain | Residue |
| A | SER89 |
| A | ASP193 |
| A | PRO194 |
| A | TYR195 |
| A | HIS225 |
| A | CYS226 |
| A | GLY227 |
| A | ASN229 |
| A | ASN232 |
| A | THR253 |
| A | ALA254 |
| A | GLY90 |
| A | ARG255 |
| A | ASP279 |
| A | HIS304 |
| A | ALA306 |
| A | TRP307 |
| A | HOH506 |
| A | HOH517 |
| A | THR117 |
| A | ILE169 |
| A | GLY170 |
| A | GLY172 |
| A | ARG173 |
| A | VAL174 |
| A | TYR192 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT A 801 |
| Chain | Residue |
| A | TYR65 |
| A | HIS66 |
| A | ARG86 |
| A | ILE87 |
| A | TRP307 |
Functional Information from PROSITE/UniProt
| site_id | PS00065 |
| Number of Residues | 28 |
| Details | D_2_HYDROXYACID_DH_1 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. LGIIGlGRVGqavalrakafgfn.VLfYD |
| Chain | Residue | Details |
| A | LEU166-ASP193 | |
| site_id | PS00671 |
| Number of Residues | 17 |
| Details | D_2_HYDROXYACID_DH_3 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. MRqGaFLVNtARGgLVD |
| Chain | Residue | Details |
| A | MET244-ASP260 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250 |
| Chain | Residue | Details |
| A | ARG255 | |
| A | GLU284 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor => ECO:0000250 |
| Chain | Residue | Details |
| A | HIS304 | |
| Chain | Residue | Details |
| A | SER89 | |
| A | ILE169 | |
| A | ASP193 | |
| A | CYS226 | |
| A | THR253 | |
| A | ASP279 | |
| Chain | Residue | Details |
| A | SER289 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1psd |
| Chain | Residue | Details |
| A | HIS304 | |
| A | GLU284 | |
