Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004146 | molecular_function | dihydrofolate reductase activity |
A | 0005829 | cellular_component | cytosol |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0031427 | biological_process | response to methotrexate |
A | 0046452 | biological_process | dihydrofolate metabolic process |
A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
A | 0046655 | biological_process | folic acid metabolic process |
A | 0046677 | biological_process | response to antibiotic |
A | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE NDP A 170 |
Chain | Residue |
A | TRP5 |
A | HIS64 |
A | HIS77 |
A | VAL79 |
A | GLY98 |
A | GLY99 |
A | ALA100 |
A | GLN101 |
A | ILE102 |
A | MET128 |
A | ALA6 |
A | ILE13 |
A | ARG43 |
A | ARG44 |
A | THR45 |
A | SER48 |
A | LEU62 |
A | THR63 |
Functional Information from PROSITE/UniProt
site_id | PS00075 |
Number of Residues | 23 |
Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. LIGkdghLPWhlpd.DlhyFraqT |
Chain | Residue | Details |
A | LEU12-THR34 | |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 159 |
Details | Domain: {"description":"DHFR","evidences":[{"source":"PROSITE-ProRule","id":"PRU00660","evidenceCode":"ECO:0000255"}]} |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"6815179","evidenceCode":"ECO:0000305"}]} |
site_id | SWS_FT_FI3 |
Number of Residues | 18 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"6815179","evidenceCode":"ECO:0000269"}]} |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | Site: {"description":"May be important for enzyme function"} |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1dhf |
Chain | Residue | Details |
A | LEU19 | |
A | ASP26 | |
site_id | MCSA1 |
Number of Residues | 9 |
Details | M-CSA 112 |
Chain | Residue | Details |
A | LEU4 | steric role |
A | LEU19 | enhance reactivity |
A | TRP21 | activator, hydrogen bond donor |
A | ASP26 | hydrogen bond acceptor, modifies pKa |
A | LEU27 | steric locator |
A | PHE30 | steric locator |
A | LEU54 | steric locator |
A | LEU94 | steric role |
A | THR116 | electrostatic stabiliser, hydrogen bond donor |