2HNK
Crystal structure of SAM-dependent O-methyltransferase from pathogenic bacterium Leptospira interrogans
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008171 | molecular_function | O-methyltransferase activity |
| A | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| A | 0032259 | biological_process | methylation |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0008171 | molecular_function | O-methyltransferase activity |
| B | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| B | 0032259 | biological_process | methylation |
| C | 0008168 | molecular_function | methyltransferase activity |
| C | 0008171 | molecular_function | O-methyltransferase activity |
| C | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| C | 0032259 | biological_process | methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A1001 |
| Chain | Residue |
| A | ARG229 |
| A | ARG231 |
| A | LEU232 |
| A | HIS234 |
| A | HOH3133 |
| C | LYS57 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B1002 |
| Chain | Residue |
| B | LEU232 |
| B | LYS57 |
| B | ARG229 |
| B | ARG231 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C1003 |
| Chain | Residue |
| A | LYS57 |
| C | ARG229 |
| C | ARG231 |
| C | LEU232 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C1004 |
| Chain | Residue |
| A | ARG22 |
| C | TYR209 |
| C | ASN210 |
| C | HOH3124 |
| site_id | AC5 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE SAH A2001 |
| Chain | Residue |
| A | MET42 |
| A | GLN43 |
| A | GLY68 |
| A | THR69 |
| A | PHE70 |
| A | SER74 |
| A | ASP92 |
| A | VAL93 |
| A | ALA121 |
| A | ASP154 |
| A | ASP156 |
| A | TYR163 |
| A | HOH3106 |
| A | HOH3116 |
| site_id | AC6 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE SAH B2002 |
| Chain | Residue |
| B | MET42 |
| B | GLN43 |
| B | GLY68 |
| B | THR69 |
| B | PHE70 |
| B | SER74 |
| B | CYS91 |
| B | ASP92 |
| B | VAL93 |
| B | ALA121 |
| B | PHE152 |
| B | ASP154 |
| B | ASP156 |
| B | TYR163 |
| B | HOH3041 |
| site_id | AC7 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE SAH C2003 |
| Chain | Residue |
| C | MET42 |
| C | GLN43 |
| C | GLY68 |
| C | THR69 |
| C | PHE70 |
| C | SER74 |
| C | ASP92 |
| C | VAL93 |
| C | TRP97 |
| C | ALA121 |
| C | ASP154 |
| C | ASP156 |
| C | TYR163 |
| C | HOH3017 |
| C | HOH3114 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG A3001 |
| Chain | Residue |
| A | GLY60 |
| A | ASP149 |
| A | LYS172 |
| A | PEG3003 |
| A | HOH3148 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG C3002 |
| Chain | Residue |
| A | PEG3003 |
| C | GLY60 |
| C | LYS172 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PEG A3003 |
| Chain | Residue |
| A | ILE58 |
| A | SER59 |
| A | PEG3001 |
| C | ILE58 |
| C | SER59 |
| C | GLY60 |
| C | PEG3002 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PEG A3004 |
| Chain | Residue |
| A | TRP184 |
| A | ASP185 |
| site_id | BC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PEG C3005 |
| Chain | Residue |
| C | TRP184 |
| C | GLU195 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG B3006 |
| Chain | Residue |
| B | LEU122 |
| B | ASN162 |
| B | HOH3093 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG A3007 |
| Chain | Residue |
| A | LYS106 |
| A | GLU107 |
| A | HOH3165 |
