Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2HN9

Crystal structure of the uridine phosphorylase from Salmonella typhimurium in complex with thymine and phosphate ion at 2.12A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004850	molecular_function	uridine phosphorylase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0009116	biological_process	nucleoside metabolic process
A	0009164	biological_process	nucleoside catabolic process
A	0009166	biological_process	nucleotide catabolic process
A	0016757	molecular_function	glycosyltransferase activity
A	0016763	molecular_function	pentosyltransferase activity
A	0044206	biological_process	UMP salvage
B	0003824	molecular_function	catalytic activity
B	0004850	molecular_function	uridine phosphorylase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0009116	biological_process	nucleoside metabolic process
B	0009164	biological_process	nucleoside catabolic process
B	0009166	biological_process	nucleotide catabolic process
B	0016757	molecular_function	glycosyltransferase activity
B	0016763	molecular_function	pentosyltransferase activity
B	0044206	biological_process	UMP salvage
C	0003824	molecular_function	catalytic activity
C	0004850	molecular_function	uridine phosphorylase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0009116	biological_process	nucleoside metabolic process
C	0009164	biological_process	nucleoside catabolic process
C	0009166	biological_process	nucleotide catabolic process
C	0016757	molecular_function	glycosyltransferase activity
C	0016763	molecular_function	pentosyltransferase activity
C	0044206	biological_process	UMP salvage
D	0003824	molecular_function	catalytic activity
D	0004850	molecular_function	uridine phosphorylase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0009116	biological_process	nucleoside metabolic process
D	0009164	biological_process	nucleoside catabolic process
D	0009166	biological_process	nucleotide catabolic process
D	0016757	molecular_function	glycosyltransferase activity
D	0016763	molecular_function	pentosyltransferase activity
D	0044206	biological_process	UMP salvage
E	0003824	molecular_function	catalytic activity
E	0004850	molecular_function	uridine phosphorylase activity
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0009116	biological_process	nucleoside metabolic process
E	0009164	biological_process	nucleoside catabolic process
E	0009166	biological_process	nucleotide catabolic process
E	0016757	molecular_function	glycosyltransferase activity
E	0016763	molecular_function	pentosyltransferase activity
E	0044206	biological_process	UMP salvage
F	0003824	molecular_function	catalytic activity
F	0004850	molecular_function	uridine phosphorylase activity
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0009116	biological_process	nucleoside metabolic process
F	0009164	biological_process	nucleoside catabolic process
F	0009166	biological_process	nucleotide catabolic process
F	0016757	molecular_function	glycosyltransferase activity
F	0016763	molecular_function	pentosyltransferase activity
F	0044206	biological_process	UMP salvage

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 A 1254

Chain	Residue
A	GLY1026
A	ARG1030
A	ILE1069
A	ARG1091
A	ILE1092
A	GLY1093
A	THR1094
F	ARG4048

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE TDR A 2001

Chain	Residue
A	GLY1096
A	PHE1162
A	GLN1166
A	ARG1168
A	GLU1196
A	MET1197
A	ILE1220
A	VAL1221
A	HOH227

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE TDR B 2002

Chain	Residue
B	HOH192
B	THR6094
B	GLY6096
B	PHE6162
B	GLN6166
B	ARG6168
B	GLU6196
B	MET6197
B	VAL6221

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE TDR F 2003

Chain	Residue
F	HOH56
F	THR4094
F	GLN4166
F	ARG4168
F	GLU4196
F	MET4197

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE TDR D 2004

Chain	Residue
D	THR3094
D	GLY3096
D	PHE3162
D	GLN3166
D	ARG3168
D	GLU3196
D	MET3197

Functional Information from PROSITE/UniProt

site_id	PS01232
Number of Residues	16
Details	PNP_UDP_1 Purine and other phosphorylases family 1 signature. StGIGgPStSIaveEL

Chain	Residue	Details
A	SER1066-LEU1081

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1t0u

Chain	Residue	Details
A	ARG1223
A	GLU1080
A	HIS1008

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1t0u

Chain	Residue	Details
B	HIS6008
B	GLU6080
B	ARG6223

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1t0u

Chain	Residue	Details
C	ARG2223
C	GLU2080
C	HIS2008

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1t0u

Chain	Residue	Details
D	GLU3080
D	HIS3008
D	ARG3223

site_id	CSA5
Number of Residues	3
Details	Annotated By Reference To The Literature 1t0u

Chain	Residue	Details
E	GLU5080
E	ARG5223
E	HIS5008

site_id	CSA6
Number of Residues	3
Details	Annotated By Reference To The Literature 1t0u

Chain	Residue	Details
F	HIS4008
F	GLU4080
F	ARG4223

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)