2HN2

Crystal structure of the CorA Mg2+ transporter homologue from T. maritima in complex with divalent cations

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0005886	cellular_component	plasma membrane
A	0006824	biological_process	cobalt ion transport
A	0015087	molecular_function	cobalt ion transmembrane transporter activity
A	0015095	molecular_function	magnesium ion transmembrane transporter activity
A	0015693	biological_process	magnesium ion transport
A	0016020	cellular_component	membrane
A	0030001	biological_process	metal ion transport
A	0042802	molecular_function	identical protein binding
A	0046873	molecular_function	metal ion transmembrane transporter activity
A	0050897	molecular_function	cobalt ion binding
A	0051260	biological_process	protein homooligomerization
A	0055085	biological_process	transmembrane transport
A	1903830	biological_process	magnesium ion transmembrane transport
B	0000287	molecular_function	magnesium ion binding
B	0005886	cellular_component	plasma membrane
B	0006824	biological_process	cobalt ion transport
B	0015087	molecular_function	cobalt ion transmembrane transporter activity
B	0015095	molecular_function	magnesium ion transmembrane transporter activity
B	0015693	biological_process	magnesium ion transport
B	0016020	cellular_component	membrane
B	0030001	biological_process	metal ion transport
B	0042802	molecular_function	identical protein binding
B	0046873	molecular_function	metal ion transmembrane transporter activity
B	0050897	molecular_function	cobalt ion binding
B	0051260	biological_process	protein homooligomerization
B	0055085	biological_process	transmembrane transport
B	1903830	biological_process	magnesium ion transmembrane transport
C	0000287	molecular_function	magnesium ion binding
C	0005886	cellular_component	plasma membrane
C	0006824	biological_process	cobalt ion transport
C	0015087	molecular_function	cobalt ion transmembrane transporter activity
C	0015095	molecular_function	magnesium ion transmembrane transporter activity
C	0015693	biological_process	magnesium ion transport
C	0016020	cellular_component	membrane
C	0030001	biological_process	metal ion transport
C	0042802	molecular_function	identical protein binding
C	0046873	molecular_function	metal ion transmembrane transporter activity
C	0050897	molecular_function	cobalt ion binding
C	0051260	biological_process	protein homooligomerization
C	0055085	biological_process	transmembrane transport
C	1903830	biological_process	magnesium ion transmembrane transport
D	0000287	molecular_function	magnesium ion binding
D	0005886	cellular_component	plasma membrane
D	0006824	biological_process	cobalt ion transport
D	0015087	molecular_function	cobalt ion transmembrane transporter activity
D	0015095	molecular_function	magnesium ion transmembrane transporter activity
D	0015693	biological_process	magnesium ion transport
D	0016020	cellular_component	membrane
D	0030001	biological_process	metal ion transport
D	0042802	molecular_function	identical protein binding
D	0046873	molecular_function	metal ion transmembrane transporter activity
D	0050897	molecular_function	cobalt ion binding
D	0051260	biological_process	protein homooligomerization
D	0055085	biological_process	transmembrane transport
D	1903830	biological_process	magnesium ion transmembrane transport
E	0000287	molecular_function	magnesium ion binding
E	0005886	cellular_component	plasma membrane
E	0006824	biological_process	cobalt ion transport
E	0015087	molecular_function	cobalt ion transmembrane transporter activity
E	0015095	molecular_function	magnesium ion transmembrane transporter activity
E	0015693	biological_process	magnesium ion transport
E	0016020	cellular_component	membrane
E	0030001	biological_process	metal ion transport
E	0042802	molecular_function	identical protein binding
E	0046873	molecular_function	metal ion transmembrane transporter activity
E	0050897	molecular_function	cobalt ion binding
E	0051260	biological_process	protein homooligomerization
E	0055085	biological_process	transmembrane transport
E	1903830	biological_process	magnesium ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA B 6201

Chain	Residue
A	ASP1253
B	ASP2089
B	GLN2095
B	LYS2098

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA C 6202

Chain	Residue
B	ASP2253
C	ASP3089
C	GLN3095
C	LYS3098

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA D 6203

Chain	Residue
D	ASP4089
D	GLN4095
C	ASP3253

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA D 6204

Chain	Residue
D	ASP4253
E	ASP5089
E	GLN5095

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 6205

Chain	Residue
A	ASP1089
A	GLN1095
A	LYS1098
E	ASP5253

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA A 6211

Chain	Residue
A	ASP1175
A	ASP1179

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA B 6212

Chain	Residue
B	ASP2175
B	ASP2179

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA C 6213

Chain	Residue
C	ASP3175
C	ASP3179
D	PRO4013

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA D 6214

Chain	Residue
D	ASP4175
D	ASP4179
E	PRO5013

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA E 6215

Chain	Residue
E	ASP5175
E	ASP5179

---

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA A 6301

Chain	Residue
A	ASP1026
A	ASP1026

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	100
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"16598263","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16857941","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16902408","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23112165","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23425532","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26871634","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	235
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	Motif: {"description":"Probable selectivity filter","evidences":[{"source":"PubMed","id":"16598263","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"16857941","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"16902408","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"23781956","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	5
Details	Site: {"description":"Essential for ion permeation","evidences":[{"source":"PubMed","id":"23091000","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	5
Details	Site: {"description":"Important for closing the ion permeation pathway in the closed state","evidences":[{"source":"PubMed","id":"16598263","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16857941","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16902408","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18276588","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	5
Details	Site: {"description":"Threonine that confers selectivity for Co(2+) transport","evidences":[{"source":"PubMed","id":"23425532","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---