2HN2

Crystal structure of the CorA Mg2+ transporter homologue from T. maritima in complex with divalent cations

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006824	biological_process	cobalt ion transport
A	0015087	molecular_function	cobalt ion transmembrane transporter activity
A	0015095	molecular_function	magnesium ion transmembrane transporter activity
A	0015693	biological_process	magnesium ion transport
A	0016020	cellular_component	membrane
A	0030001	biological_process	metal ion transport
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0046873	molecular_function	metal ion transmembrane transporter activity
A	0050897	molecular_function	cobalt ion binding
A	0051260	biological_process	protein homooligomerization
A	0055085	biological_process	transmembrane transport
A	1903830	biological_process	magnesium ion transmembrane transport
B	0000287	molecular_function	magnesium ion binding
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006824	biological_process	cobalt ion transport
B	0015087	molecular_function	cobalt ion transmembrane transporter activity
B	0015095	molecular_function	magnesium ion transmembrane transporter activity
B	0015693	biological_process	magnesium ion transport
B	0016020	cellular_component	membrane
B	0030001	biological_process	metal ion transport
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0046873	molecular_function	metal ion transmembrane transporter activity
B	0050897	molecular_function	cobalt ion binding
B	0051260	biological_process	protein homooligomerization
B	0055085	biological_process	transmembrane transport
B	1903830	biological_process	magnesium ion transmembrane transport
C	0000287	molecular_function	magnesium ion binding
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006824	biological_process	cobalt ion transport
C	0015087	molecular_function	cobalt ion transmembrane transporter activity
C	0015095	molecular_function	magnesium ion transmembrane transporter activity
C	0015693	biological_process	magnesium ion transport
C	0016020	cellular_component	membrane
C	0030001	biological_process	metal ion transport
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0046873	molecular_function	metal ion transmembrane transporter activity
C	0050897	molecular_function	cobalt ion binding
C	0051260	biological_process	protein homooligomerization
C	0055085	biological_process	transmembrane transport
C	1903830	biological_process	magnesium ion transmembrane transport
D	0000287	molecular_function	magnesium ion binding
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006824	biological_process	cobalt ion transport
D	0015087	molecular_function	cobalt ion transmembrane transporter activity
D	0015095	molecular_function	magnesium ion transmembrane transporter activity
D	0015693	biological_process	magnesium ion transport
D	0016020	cellular_component	membrane
D	0030001	biological_process	metal ion transport
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
D	0046873	molecular_function	metal ion transmembrane transporter activity
D	0050897	molecular_function	cobalt ion binding
D	0051260	biological_process	protein homooligomerization
D	0055085	biological_process	transmembrane transport
D	1903830	biological_process	magnesium ion transmembrane transport
E	0000287	molecular_function	magnesium ion binding
E	0005886	cellular_component	plasma membrane
E	0006811	biological_process	monoatomic ion transport
E	0006824	biological_process	cobalt ion transport
E	0015087	molecular_function	cobalt ion transmembrane transporter activity
E	0015095	molecular_function	magnesium ion transmembrane transporter activity
E	0015693	biological_process	magnesium ion transport
E	0016020	cellular_component	membrane
E	0030001	biological_process	metal ion transport
E	0042802	molecular_function	identical protein binding
E	0046872	molecular_function	metal ion binding
E	0046873	molecular_function	metal ion transmembrane transporter activity
E	0050897	molecular_function	cobalt ion binding
E	0051260	biological_process	protein homooligomerization
E	0055085	biological_process	transmembrane transport
E	1903830	biological_process	magnesium ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA B 6201

Chain	Residue
A	ASP1253
B	ASP2089
B	GLN2095
B	LYS2098

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA C 6202

Chain	Residue
B	ASP2253
C	ASP3089
C	GLN3095
C	LYS3098

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA D 6203

Chain	Residue
D	ASP4089
D	GLN4095
C	ASP3253

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA D 6204

Chain	Residue
D	ASP4253
E	ASP5089
E	GLN5095

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 6205

Chain	Residue
A	ASP1089
A	GLN1095
A	LYS1098
E	ASP5253

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA A 6211

Chain	Residue
A	ASP1175
A	ASP1179

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA B 6212

Chain	Residue
B	ASP2175
B	ASP2179

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA C 6213

Chain	Residue
C	ASP3175
C	ASP3179
D	PRO4013

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA D 6214

Chain	Residue
D	ASP4175
D	ASP4179
E	PRO5013

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA E 6215

Chain	Residue
E	ASP5175
E	ASP5179

---

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA A 6301

Chain	Residue
A	ASP1026
A	ASP1026

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1480
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
A	MET1001-LYS1292
E	LYS5346-LEU5351
A	LYS1346-LEU1351
B	MET2001-LYS2292
B	LYS2346-LEU2351
C	MET3001-LYS3292
C	LYS3346-LEU3351
D	MET4001-LYS4292
D	LYS4346-LEU4351
E	MET5001-LYS5292

---

site_id	SWS_FT_FI2
Number of Residues	200
Details	TRANSMEM: Helical => ECO:0000269|PubMed:16598263, ECO:0000269|PubMed:16857941, ECO:0000269|PubMed:16902408, ECO:0000269|PubMed:23112165, ECO:0000269|PubMed:23425532, ECO:0000269|PubMed:26871634

Chain	Residue	Details
A	VAL1293-MET1313
E	TRP5325-PHE5345
A	TRP1325-PHE1345
B	VAL2293-MET2313
B	TRP2325-PHE2345
C	VAL3293-MET3313
C	TRP3325-PHE3345
D	VAL4293-MET4313
D	TRP4325-PHE4345
E	VAL5293-MET5313

---

site_id	SWS_FT_FI3
Number of Residues	50
Details	TOPO_DOM: Extracellular => ECO:0000305

Chain	Residue	Details
A	ASN1314-LYS1324
B	ASN2314-LYS2324
C	ASN3314-LYS3324
D	ASN4314-LYS4324
E	ASN5314-LYS5324

---

site_id	SWS_FT_FI4
Number of Residues	5
Details	SITE: Essential for ion permeation => ECO:0000269|PubMed:23091000

Chain	Residue	Details
A	ASN1288
B	ASN2288
C	ASN3288
D	ASN4288
E	ASN5288

---

site_id	SWS_FT_FI5
Number of Residues	5
Details	SITE: Important for closing the ion permeation pathway in the closed state => ECO:0000269|PubMed:16598263, ECO:0000269|PubMed:16857941, ECO:0000269|PubMed:16902408, ECO:0000269|PubMed:18276588

Chain	Residue	Details
A	LEU1294
B	LEU2294
C	LEU3294
D	LEU4294
E	LEU5294

---

site_id	SWS_FT_FI6
Number of Residues	5
Details	SITE: Threonine that confers selectivity for Co(2+) transport => ECO:0000269|PubMed:23425532

Chain	Residue	Details
A	THR1295
B	THR2295
C	THR3295
D	THR4295
E	THR5295

---