2HL2

Crystal structure of the editing domain of threonyl-tRNA synthetase from Pyrococcus abyssi in complex with an analog of seryladenylate

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Functional Information from GO Data

ChainGOidnamespacecontents
A0005737cellular_componentcytoplasm
A0005524molecular_functionATP binding
A0004829molecular_functionthreonine-tRNA ligase activity
A0000049molecular_functiontRNA binding
A0008270molecular_functionzinc ion binding
A0006435biological_processthreonyl-tRNA aminoacylation
B0005737cellular_componentcytoplasm
B0005524molecular_functionATP binding
B0004829molecular_functionthreonine-tRNA ligase activity
B0000049molecular_functiontRNA binding
B0008270molecular_functionzinc ion binding
B0006435biological_processthreonyl-tRNA aminoacylation
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC110BINDING SITE FOR RESIDUE SSA A 500
ChainResidue
AALA19
ALEU20
AILE43
AVAL45
ALEU88
AALA89
AALA94
APHE117
AGLY118
ALYS121

AC213BINDING SITE FOR RESIDUE SSA B 501
ChainResidue
AHOH1047
BALA19
BLEU20
BILE43
BVAL45
BPHE81
BALA82
BALA89
BALA94
BPHE117
BGLY118
BTYR120
BHOH1075

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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
SSA_2hl2_A_500195'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE binding site
ChainResidueligand
AALA19-LEU20SSA: 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE
AILE43-VAL45SSA: 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE
APRO80-ALA82SSA: 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE
ALEU88-ALA89SSA: 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE
APRO91SSA: 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE
AALA94SSA: 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE
ALEU98SSA: 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE
APRO116-LYS121SSA: 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE

SSA_2hl2_B_501205'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE binding site
ChainResidueligand
BALA19-LEU20SSA: 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE
BILE43-VAL45SSA: 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE
BPRO80-HIS83SSA: 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE
BLEU88-ALA89SSA: 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE
BPRO91SSA: 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE
BALA94SSA: 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE
BLEU98SSA: 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE
BPRO116-LYS121SSA: 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE

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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
SWS_FT_FI13Zinc; catalytic (By similarity)
ChainResidueDetails
ANA*
ANA*
ANA*

SWS_FT_FI23Zinc; catalytic (By similarity)
ChainResidueDetails
BNA*
BNA*
BNA*

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Catalytic Information from CSA

site_idNumber of ResiduesDetails