2HKE

Mevalonate diphosphate decarboxylase from Trypanosoma brucei

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004163	molecular_function	diphosphomevalonate decarboxylase activity
A	0005524	molecular_function	ATP binding
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005929	cellular_component	cilium
A	0006629	biological_process	lipid metabolic process
A	0006694	biological_process	steroid biosynthetic process
A	0006695	biological_process	cholesterol biosynthetic process
A	0008202	biological_process	steroid metabolic process
A	0008203	biological_process	cholesterol metabolic process
A	0008299	biological_process	isoprenoid biosynthetic process
A	0016126	biological_process	sterol biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016310	biological_process	phosphorylation
A	0016829	molecular_function	lyase activity
A	0016831	molecular_function	carboxy-lyase activity
A	0019287	biological_process	isopentenyl diphosphate biosynthetic process, mevalonate pathway
B	0000166	molecular_function	nucleotide binding
B	0004163	molecular_function	diphosphomevalonate decarboxylase activity
B	0005524	molecular_function	ATP binding
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005929	cellular_component	cilium
B	0006629	biological_process	lipid metabolic process
B	0006694	biological_process	steroid biosynthetic process
B	0006695	biological_process	cholesterol biosynthetic process
B	0008202	biological_process	steroid metabolic process
B	0008203	biological_process	cholesterol metabolic process
B	0008299	biological_process	isoprenoid biosynthetic process
B	0016126	biological_process	sterol biosynthetic process
B	0016301	molecular_function	kinase activity
B	0016310	biological_process	phosphorylation
B	0016829	molecular_function	lyase activity
B	0016831	molecular_function	carboxy-lyase activity
B	0019287	biological_process	isopentenyl diphosphate biosynthetic process, mevalonate pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 381

Chain	Residue
A	TYR19
A	LYS22
A	ILE30
A	ARG77
A	SER144
A	GLY145
A	THR200
A	HOH423
A	HOH641

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 B 381

Chain	Residue
B	TYR19
B	LYS22
B	ILE30
B	ARG77
B	SER144
B	GLY145
B	THR200
B	HOH464

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 382

Chain	Residue
A	ARG274
A	ILE349
A	ASP350
A	HOH610
A	HOH710
A	HOH746
A	HOH777

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 383

Chain	Residue
A	SER42
A	ALA43
A	GLY365
A	CYS366
A	HOH385
A	HOH657
A	HOH694

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 382

Chain	Residue
B	ARG274
B	ILE349
B	ASP350

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 383

Chain	Residue
B	SER42
B	ALA43
B	GLY365
B	CYS366
B	HOH509

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1fwk

Chain	Residue	Details
A	ASP196

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1fwk

Chain	Residue	Details
B	ASP196

---