Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2HK8

Crystal structure of shikimate dehydrogenase from aquifex aeolicus at 2.35 angstrom resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004764	molecular_function	shikimate 3-dehydrogenase (NADP+) activity
A	0005829	cellular_component	cytosol
A	0008652	biological_process	amino acid biosynthetic process
A	0009073	biological_process	aromatic amino acid family biosynthetic process
A	0009423	biological_process	chorismate biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0019632	biological_process	shikimate metabolic process
A	0050661	molecular_function	NADP binding
B	0004764	molecular_function	shikimate 3-dehydrogenase (NADP+) activity
B	0005829	cellular_component	cytosol
B	0008652	biological_process	amino acid biosynthetic process
B	0009073	biological_process	aromatic amino acid family biosynthetic process
B	0009423	biological_process	chorismate biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0019632	biological_process	shikimate metabolic process
B	0050661	molecular_function	NADP binding
C	0004764	molecular_function	shikimate 3-dehydrogenase (NADP+) activity
C	0005829	cellular_component	cytosol
C	0008652	biological_process	amino acid biosynthetic process
C	0009073	biological_process	aromatic amino acid family biosynthetic process
C	0009423	biological_process	chorismate biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0019632	biological_process	shikimate metabolic process
C	0050661	molecular_function	NADP binding
D	0004764	molecular_function	shikimate 3-dehydrogenase (NADP+) activity
D	0005829	cellular_component	cytosol
D	0008652	biological_process	amino acid biosynthetic process
D	0009073	biological_process	aromatic amino acid family biosynthetic process
D	0009423	biological_process	chorismate biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0019632	biological_process	shikimate metabolic process
D	0050661	molecular_function	NADP binding
E	0004764	molecular_function	shikimate 3-dehydrogenase (NADP+) activity
E	0005829	cellular_component	cytosol
E	0008652	biological_process	amino acid biosynthetic process
E	0009073	biological_process	aromatic amino acid family biosynthetic process
E	0009423	biological_process	chorismate biosynthetic process
E	0016491	molecular_function	oxidoreductase activity
E	0019632	biological_process	shikimate metabolic process
E	0050661	molecular_function	NADP binding
F	0004764	molecular_function	shikimate 3-dehydrogenase (NADP+) activity
F	0005829	cellular_component	cytosol
F	0008652	biological_process	amino acid biosynthetic process
F	0009073	biological_process	aromatic amino acid family biosynthetic process
F	0009423	biological_process	chorismate biosynthetic process
F	0016491	molecular_function	oxidoreductase activity
F	0019632	biological_process	shikimate metabolic process
F	0050661	molecular_function	NADP binding
G	0004764	molecular_function	shikimate 3-dehydrogenase (NADP+) activity
G	0005829	cellular_component	cytosol
G	0008652	biological_process	amino acid biosynthetic process
G	0009073	biological_process	aromatic amino acid family biosynthetic process
G	0009423	biological_process	chorismate biosynthetic process
G	0016491	molecular_function	oxidoreductase activity
G	0019632	biological_process	shikimate metabolic process
G	0050661	molecular_function	NADP binding
H	0004764	molecular_function	shikimate 3-dehydrogenase (NADP+) activity
H	0005829	cellular_component	cytosol
H	0008652	biological_process	amino acid biosynthetic process
H	0009073	biological_process	aromatic amino acid family biosynthetic process
H	0009423	biological_process	chorismate biosynthetic process
H	0016491	molecular_function	oxidoreductase activity
H	0019632	biological_process	shikimate metabolic process
H	0050661	molecular_function	NADP binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00222","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17649975","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	104
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00222","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17649975","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00222","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	40
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00222","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17649975","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1nvt

Chain	Residue	Details
A	ASN97

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1nvt

Chain	Residue	Details
B	ASN97

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1nvt

Chain	Residue	Details
C	ASN97

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1nvt

Chain	Residue	Details
D	ASN97

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 1nvt

Chain	Residue	Details
E	ASN97

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 1nvt

Chain	Residue	Details
F	ASN97

site_id	CSA7
Number of Residues	1
Details	Annotated By Reference To The Literature 1nvt

Chain	Residue	Details
G	ASN97

site_id	CSA8
Number of Residues	1
Details	Annotated By Reference To The Literature 1nvt

Chain	Residue	Details
H	ASN97

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)