2HJR
Crystal Structure of Cryptosporidium parvum malate dehydrogenase
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0004459 | molecular_function | L-lactate dehydrogenase activity |
A | 0006089 | biological_process | lactate metabolic process |
A | 0006090 | biological_process | pyruvate metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
A | 0019752 | biological_process | carboxylic acid metabolic process |
B | 0003824 | molecular_function | catalytic activity |
B | 0004459 | molecular_function | L-lactate dehydrogenase activity |
B | 0006089 | biological_process | lactate metabolic process |
B | 0006090 | biological_process | pyruvate metabolic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
B | 0019752 | biological_process | carboxylic acid metabolic process |
C | 0003824 | molecular_function | catalytic activity |
C | 0004459 | molecular_function | L-lactate dehydrogenase activity |
C | 0006089 | biological_process | lactate metabolic process |
C | 0006090 | biological_process | pyruvate metabolic process |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
C | 0019752 | biological_process | carboxylic acid metabolic process |
D | 0003824 | molecular_function | catalytic activity |
D | 0004459 | molecular_function | L-lactate dehydrogenase activity |
D | 0006089 | biological_process | lactate metabolic process |
D | 0006090 | biological_process | pyruvate metabolic process |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
D | 0019752 | biological_process | carboxylic acid metabolic process |
E | 0003824 | molecular_function | catalytic activity |
E | 0004459 | molecular_function | L-lactate dehydrogenase activity |
E | 0006089 | biological_process | lactate metabolic process |
E | 0006090 | biological_process | pyruvate metabolic process |
E | 0016491 | molecular_function | oxidoreductase activity |
E | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
E | 0019752 | biological_process | carboxylic acid metabolic process |
F | 0003824 | molecular_function | catalytic activity |
F | 0004459 | molecular_function | L-lactate dehydrogenase activity |
F | 0006089 | biological_process | lactate metabolic process |
F | 0006090 | biological_process | pyruvate metabolic process |
F | 0016491 | molecular_function | oxidoreductase activity |
F | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
F | 0019752 | biological_process | carboxylic acid metabolic process |
G | 0003824 | molecular_function | catalytic activity |
G | 0004459 | molecular_function | L-lactate dehydrogenase activity |
G | 0006089 | biological_process | lactate metabolic process |
G | 0006090 | biological_process | pyruvate metabolic process |
G | 0016491 | molecular_function | oxidoreductase activity |
G | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
G | 0019752 | biological_process | carboxylic acid metabolic process |
H | 0003824 | molecular_function | catalytic activity |
H | 0004459 | molecular_function | L-lactate dehydrogenase activity |
H | 0006089 | biological_process | lactate metabolic process |
H | 0006090 | biological_process | pyruvate metabolic process |
H | 0016491 | molecular_function | oxidoreductase activity |
H | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
H | 0019752 | biological_process | carboxylic acid metabolic process |
I | 0003824 | molecular_function | catalytic activity |
I | 0004459 | molecular_function | L-lactate dehydrogenase activity |
I | 0006089 | biological_process | lactate metabolic process |
I | 0006090 | biological_process | pyruvate metabolic process |
I | 0016491 | molecular_function | oxidoreductase activity |
I | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
I | 0019752 | biological_process | carboxylic acid metabolic process |
J | 0003824 | molecular_function | catalytic activity |
J | 0004459 | molecular_function | L-lactate dehydrogenase activity |
J | 0006089 | biological_process | lactate metabolic process |
J | 0006090 | biological_process | pyruvate metabolic process |
J | 0016491 | molecular_function | oxidoreductase activity |
J | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
J | 0019752 | biological_process | carboxylic acid metabolic process |
K | 0003824 | molecular_function | catalytic activity |
K | 0004459 | molecular_function | L-lactate dehydrogenase activity |
K | 0006089 | biological_process | lactate metabolic process |
K | 0006090 | biological_process | pyruvate metabolic process |
K | 0016491 | molecular_function | oxidoreductase activity |
K | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
K | 0019752 | biological_process | carboxylic acid metabolic process |
L | 0003824 | molecular_function | catalytic activity |
L | 0004459 | molecular_function | L-lactate dehydrogenase activity |
L | 0006089 | biological_process | lactate metabolic process |
L | 0006090 | biological_process | pyruvate metabolic process |
L | 0016491 | molecular_function | oxidoreductase activity |
L | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
L | 0019752 | biological_process | carboxylic acid metabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE CIT A 2001 |
Chain | Residue |
A | ARG94 |
A | HOH3028 |
A | HOH3094 |
A | ARG100 |
A | ASN132 |
A | MET155 |
A | ARG163 |
A | HIS187 |
A | GLY230 |
A | ALA242 |
A | PRO246 |
site_id | AC2 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE CIT B 2002 |
Chain | Residue |
B | ILE25 |
B | ARG94 |
B | ARG100 |
B | ILE130 |
B | ASN132 |
B | LEU159 |
B | ARG163 |
B | HIS187 |
B | GLY230 |
B | ALA242 |
B | APR3012 |
B | HOH3024 |
B | HOH3042 |
B | HOH3064 |
B | HOH3138 |
site_id | AC3 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE CIT C 2003 |
Chain | Residue |
C | ARG94 |
C | ARG100 |
C | ASN132 |
C | MET155 |
C | LEU159 |
C | ARG163 |
C | HIS187 |
C | GLY230 |
C | ALA242 |
C | PRO246 |
C | APR3002 |
C | HOH3020 |
C | HOH3026 |
C | HOH3116 |
site_id | AC4 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE CIT D 2004 |
Chain | Residue |
D | ARG94 |
D | ARG100 |
D | ASN132 |
D | MET155 |
D | LEU159 |
D | ARG163 |
D | HIS187 |
D | GLY230 |
D | ALA242 |
D | PRO246 |
D | APR3003 |
D | HOH3014 |
D | HOH3022 |
D | HOH3038 |
D | HOH3081 |
site_id | AC5 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE CIT H 2005 |
Chain | Residue |
H | ARG94 |
H | ARG100 |
H | ASN132 |
H | MET155 |
H | LEU159 |
H | ARG163 |
H | HIS187 |
H | GLY230 |
H | ALA242 |
H | APR3007 |
H | HOH3026 |
H | HOH3046 |
site_id | AC6 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE CIT G 2006 |
Chain | Residue |
G | ARG94 |
G | ARG100 |
G | ASN132 |
G | MET155 |
G | LEU159 |
G | ARG163 |
G | HIS187 |
G | GLY230 |
G | ALA242 |
G | APR3006 |
G | HOH3020 |
G | HOH3021 |
G | HOH3032 |
site_id | AC7 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE CIT F 2007 |
Chain | Residue |
F | ARG94 |
F | ARG100 |
F | ASN132 |
F | MET155 |
F | LEU159 |
F | ARG163 |
F | HIS187 |
F | GLY230 |
F | ALA242 |
F | PRO246 |
F | HOH3033 |
F | HOH3123 |
F | HOH3125 |
site_id | AC8 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE CIT E 2008 |
Chain | Residue |
E | HIS187 |
E | GLY230 |
E | PRO246 |
E | APR3004 |
E | HOH3045 |
E | HOH3046 |
E | HOH3072 |
E | ARG94 |
E | ARG100 |
E | ILE130 |
E | ASN132 |
E | LEU159 |
E | ARG163 |
site_id | AC9 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE CIT L 2010 |
Chain | Residue |
L | ARG94 |
L | ARG100 |
L | ASN132 |
L | LEU159 |
L | ARG163 |
L | HIS187 |
L | GLY230 |
L | ILE233 |
L | VAL234 |
L | SER241 |
L | ALA242 |
L | APR3011 |
L | HOH3056 |
site_id | BC1 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE CIT I 2011 |
Chain | Residue |
I | ARG94 |
I | ARG100 |
I | ILE130 |
I | ASN132 |
I | MET155 |
I | LEU159 |
I | ARG163 |
I | HIS187 |
I | GLY230 |
I | ALA242 |
I | APR3008 |
I | HOH3024 |
I | HOH3038 |
I | HOH3050 |
site_id | BC2 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE CIT J 2012 |
Chain | Residue |
J | ARG94 |
J | ARG100 |
J | ASN132 |
J | LEU159 |
J | ARG163 |
J | HIS187 |
J | GLY230 |
J | VAL234 |
J | SER241 |
J | ALA242 |
J | PRO246 |
J | APR3009 |
J | HOH3024 |
J | HOH3086 |
site_id | BC3 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE CIT K 2013 |
Chain | Residue |
K | ARG94 |
K | ARG100 |
K | ASN132 |
K | MET155 |
K | LEU159 |
K | ARG163 |
K | HIS187 |
K | GLY230 |
K | ALA242 |
K | PRO246 |
K | APR3010 |
K | HOH3079 |
K | HOH3102 |
K | HOH3113 |
K | HOH3114 |
site_id | BC4 |
Number of Residues | 25 |
Details | BINDING SITE FOR RESIDUE APR A 3001 |
Chain | Residue |
A | GLY21 |
A | GLY23 |
A | GLN24 |
A | ILE25 |
A | ASP45 |
A | ILE46 |
A | ILE47 |
A | TYR77 |
A | THR89 |
A | ALA90 |
A | GLY91 |
A | VAL92 |
A | PRO93 |
A | ASN107 |
A | ILE110 |
A | THR131 |
A | ASN132 |
A | HOH3014 |
A | HOH3023 |
A | HOH3028 |
A | HOH3039 |
A | HOH3041 |
A | HOH3075 |
A | HOH3078 |
A | HOH3080 |
site_id | BC5 |
Number of Residues | 25 |
Details | BINDING SITE FOR RESIDUE APR B 3012 |
Chain | Residue |
B | GLY23 |
B | GLN24 |
B | ILE25 |
B | ASP45 |
B | ILE46 |
B | ILE47 |
B | TYR77 |
B | THR89 |
B | ALA90 |
B | GLY91 |
B | VAL92 |
B | PRO93 |
B | ASN107 |
B | THR131 |
B | ASN132 |
B | CIT2002 |
B | HOH3015 |
B | HOH3020 |
B | HOH3045 |
B | HOH3058 |
B | HOH3064 |
B | HOH3076 |
B | HOH3096 |
B | HOH3103 |
B | HOH3107 |
site_id | BC6 |
Number of Residues | 26 |
Details | BINDING SITE FOR RESIDUE APR C 3002 |
Chain | Residue |
C | GLY21 |
C | GLY23 |
C | GLN24 |
C | ILE25 |
C | ASP45 |
C | ILE46 |
C | ILE47 |
C | TYR77 |
C | THR89 |
C | ALA90 |
C | GLY91 |
C | VAL92 |
C | PRO93 |
C | ASN107 |
C | ILE110 |
C | ILE130 |
C | THR131 |
C | ASN132 |
C | CIT2003 |
C | HOH3010 |
C | HOH3026 |
C | HOH3044 |
C | HOH3061 |
C | HOH3073 |
C | HOH3110 |
C | HOH3113 |
site_id | BC7 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE APR D 3003 |
Chain | Residue |
D | GLY21 |
D | GLY23 |
D | GLN24 |
D | ILE25 |
D | ASP45 |
D | ILE46 |
D | ILE47 |
D | TYR77 |
D | THR89 |
D | ALA90 |
D | GLY91 |
D | VAL92 |
D | ASN107 |
D | THR131 |
D | ASN132 |
D | CIT2004 |
D | HOH3005 |
D | HOH3038 |
D | HOH3039 |
D | HOH3081 |
D | HOH3092 |
site_id | BC8 |
Number of Residues | 23 |
Details | BINDING SITE FOR RESIDUE APR E 3004 |
Chain | Residue |
E | GLY21 |
E | GLY23 |
E | GLN24 |
E | ILE25 |
E | ASP45 |
E | ILE46 |
E | ILE47 |
E | TYR77 |
E | THR89 |
E | ALA90 |
E | GLY91 |
E | VAL92 |
E | PRO93 |
E | ASN107 |
E | ILE110 |
E | THR131 |
E | ASN132 |
E | CIT2008 |
E | HOH3015 |
E | HOH3045 |
E | HOH3052 |
E | HOH3072 |
E | HOH3098 |
site_id | BC9 |
Number of Residues | 26 |
Details | BINDING SITE FOR RESIDUE APR F 3005 |
Chain | Residue |
F | GLY21 |
F | GLY23 |
F | GLN24 |
F | ILE25 |
F | ASP45 |
F | ILE46 |
F | ILE47 |
F | TYR77 |
F | THR89 |
F | ALA90 |
F | GLY91 |
F | VAL92 |
F | PRO93 |
F | ASN107 |
F | ILE110 |
F | ILE130 |
F | THR131 |
F | ASN132 |
F | HOH3033 |
F | HOH3036 |
F | HOH3053 |
F | HOH3072 |
F | HOH3093 |
F | HOH3113 |
F | HOH3120 |
F | HOH3130 |
site_id | CC1 |
Number of Residues | 23 |
Details | BINDING SITE FOR RESIDUE APR G 3006 |
Chain | Residue |
G | GLY21 |
G | GLY23 |
G | GLN24 |
G | ILE25 |
G | ASP45 |
G | ILE46 |
G | ILE47 |
G | TYR77 |
G | THR89 |
G | ALA90 |
G | GLY91 |
G | VAL92 |
G | PRO93 |
G | ASN107 |
G | ILE110 |
G | ILE130 |
G | THR131 |
G | ASN132 |
G | CIT2006 |
G | HOH3017 |
G | HOH3030 |
G | HOH3080 |
G | HOH3122 |
site_id | CC2 |
Number of Residues | 25 |
Details | BINDING SITE FOR RESIDUE APR H 3007 |
Chain | Residue |
H | GLY21 |
H | GLY23 |
H | GLN24 |
H | ILE25 |
H | ASP45 |
H | ILE46 |
H | ILE47 |
H | TYR77 |
H | THR89 |
H | ALA90 |
H | GLY91 |
H | VAL92 |
H | PRO93 |
H | ASN107 |
H | ILE110 |
H | ILE130 |
H | THR131 |
H | ASN132 |
H | CIT2005 |
H | HOH3010 |
H | HOH3026 |
H | HOH3048 |
H | HOH3057 |
H | HOH3064 |
H | HOH3103 |
site_id | CC3 |
Number of Residues | 23 |
Details | BINDING SITE FOR RESIDUE APR I 3008 |
Chain | Residue |
I | GLY23 |
I | GLN24 |
I | ILE25 |
I | ASP45 |
I | ILE46 |
I | ILE47 |
I | TYR77 |
I | THR89 |
I | ALA90 |
I | GLY91 |
I | VAL92 |
I | PRO93 |
I | ASN107 |
I | ILE110 |
I | ILE130 |
I | THR131 |
I | ASN132 |
I | CIT2011 |
I | HOH3013 |
I | HOH3038 |
I | HOH3051 |
I | HOH3065 |
I | HOH3074 |
site_id | CC4 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE APR J 3009 |
Chain | Residue |
J | GLY21 |
J | GLY23 |
J | GLN24 |
J | ILE25 |
J | ASP45 |
J | ILE46 |
J | ILE47 |
J | TYR77 |
J | THR89 |
J | ALA90 |
J | GLY91 |
J | VAL92 |
J | ASN107 |
J | THR131 |
J | ASN132 |
J | CIT2012 |
J | HOH3021 |
J | HOH3024 |
J | HOH3072 |
J | HOH3079 |
site_id | CC5 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE APR K 3010 |
Chain | Residue |
K | GLY21 |
K | GLY23 |
K | GLN24 |
K | ILE25 |
K | ASP45 |
K | ILE46 |
K | ILE47 |
K | TYR77 |
K | THR89 |
K | ALA90 |
K | GLY91 |
K | VAL92 |
K | PRO93 |
K | ASN107 |
K | THR131 |
K | ASN132 |
K | CIT2013 |
K | HOH3022 |
K | HOH3066 |
K | HOH3079 |
K | HOH3092 |
K | HOH3102 |
site_id | CC6 |
Number of Residues | 26 |
Details | BINDING SITE FOR RESIDUE APR L 3011 |
Chain | Residue |
L | GLY21 |
L | GLY23 |
L | GLN24 |
L | ILE25 |
L | ASP45 |
L | ILE46 |
L | ILE47 |
L | TYR77 |
L | THR89 |
L | ALA90 |
L | GLY91 |
L | VAL92 |
L | PRO93 |
L | ASN107 |
L | ILE110 |
L | ILE130 |
L | THR131 |
L | ASN132 |
L | CIT2010 |
L | HOH3012 |
L | HOH3026 |
L | HOH3056 |
L | HOH3060 |
L | HOH3086 |
L | HOH3088 |
L | HOH3091 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1emd |
Chain | Residue | Details |
A | HIS187 | |
A | ASP160 |
site_id | CSA10 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1emd |
Chain | Residue | Details |
J | HIS187 | |
J | ASP160 |
site_id | CSA11 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1emd |
Chain | Residue | Details |
K | HIS187 | |
K | ASP160 |
site_id | CSA12 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1emd |
Chain | Residue | Details |
L | HIS187 | |
L | ASP160 |
site_id | CSA13 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1emd |
Chain | Residue | Details |
A | HIS187 | |
A | ASP160 | |
A | ARG163 |
site_id | CSA14 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1emd |
Chain | Residue | Details |
B | HIS187 | |
B | ASP160 | |
B | ARG163 |
site_id | CSA15 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1emd |
Chain | Residue | Details |
C | HIS187 | |
C | ASP160 | |
C | ARG163 |
site_id | CSA16 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1emd |
Chain | Residue | Details |
D | HIS187 | |
D | ASP160 | |
D | ARG163 |
site_id | CSA17 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1emd |
Chain | Residue | Details |
E | HIS187 | |
E | ASP160 | |
E | ARG163 |
site_id | CSA18 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1emd |
Chain | Residue | Details |
F | HIS187 | |
F | ASP160 | |
F | ARG163 |
site_id | CSA19 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1emd |
Chain | Residue | Details |
G | HIS187 | |
G | ASP160 | |
G | ARG163 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1emd |
Chain | Residue | Details |
B | HIS187 | |
B | ASP160 |
site_id | CSA20 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1emd |
Chain | Residue | Details |
H | HIS187 | |
H | ASP160 | |
H | ARG163 |
site_id | CSA21 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1emd |
Chain | Residue | Details |
I | HIS187 | |
I | ASP160 | |
I | ARG163 |
site_id | CSA22 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1emd |
Chain | Residue | Details |
J | HIS187 | |
J | ASP160 | |
J | ARG163 |
site_id | CSA23 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1emd |
Chain | Residue | Details |
K | HIS187 | |
K | ASP160 | |
K | ARG163 |
site_id | CSA24 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1emd |
Chain | Residue | Details |
L | HIS187 | |
L | ASP160 | |
L | ARG163 |
site_id | CSA3 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1emd |
Chain | Residue | Details |
C | HIS187 | |
C | ASP160 |
site_id | CSA4 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1emd |
Chain | Residue | Details |
D | HIS187 | |
D | ASP160 |
site_id | CSA5 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1emd |
Chain | Residue | Details |
E | HIS187 | |
E | ASP160 |
site_id | CSA6 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1emd |
Chain | Residue | Details |
F | HIS187 | |
F | ASP160 |
site_id | CSA7 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1emd |
Chain | Residue | Details |
G | HIS187 | |
G | ASP160 |
site_id | CSA8 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1emd |
Chain | Residue | Details |
H | HIS187 | |
H | ASP160 |
site_id | CSA9 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1emd |
Chain | Residue | Details |
I | HIS187 | |
I | ASP160 |