2HFH

THE NMR STRUCTURES OF A WINGED HELIX PROTEIN: GENESIS, 20 STRUCTURES

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000785	cellular_component	chromatin
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
A	0001227	molecular_function	DNA-binding transcription repressor activity, RNA polymerase II-specific
A	0001701	biological_process	in utero embryonic development
A	0001829	biological_process	trophectodermal cell differentiation
A	0001892	biological_process	embryonic placenta development
A	0003677	molecular_function	DNA binding
A	0003690	molecular_function	double-stranded DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
A	0043565	molecular_function	sequence-specific DNA binding
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	1990830	biological_process	cellular response to leukemia inhibitory factor
A	1990837	molecular_function	sequence-specific double-stranded DNA binding

Functional Information from PROSITE/UniProt

site_id	PS00657
Number of Residues	14
Details	FORK_HEAD_1 Fork head domain signature 1. KPPYSYiaLitm.AI

Chain	Residue	Details
A	LYS3-ILE16

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site_id	PS00658
Number of Residues	7
Details	FORK_HEAD_2 Fork head domain signature 2. WQNSIRH

Chain	Residue	Details
A	TRP47-HIS53

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	94
Details	DNA_BIND: Fork-head => ECO:0000255|PROSITE-ProRule:PRU00089

Chain	Residue	Details
A	LYS3-LYS97

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