2HDB
HMG-CoA synthase from Enterococcus faecalis. Mutation alanine 110 to glycine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004421 | molecular_function | hydroxymethylglutaryl-CoA synthase activity |
| A | 0006084 | biological_process | acetyl-CoA metabolic process |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0010142 | biological_process | farnesyl diphosphate biosynthetic process, mevalonate pathway |
| A | 0016746 | molecular_function | acyltransferase activity |
| B | 0004421 | molecular_function | hydroxymethylglutaryl-CoA synthase activity |
| B | 0006084 | biological_process | acetyl-CoA metabolic process |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0010142 | biological_process | farnesyl diphosphate biosynthetic process, mevalonate pathway |
| B | 0016746 | molecular_function | acyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 401 |
| Chain | Residue |
| A | LYS7 |
| A | THR64 |
| A | ARG167 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 402 |
| Chain | Residue |
| B | THR64 |
| B | LYS65 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 403 |
| Chain | Residue |
| B | HOH634 |
| B | HOH660 |
| B | LYS7 |
| B | THR64 |
| B | ARG167 |
| B | HOH575 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE MES A 501 |
| Chain | Residue |
| A | CYS111 |
| A | TYR143 |
| A | VAL196 |
| A | SER201 |
| A | HIS233 |
| A | PRO235 |
| A | ASN275 |
| A | TYR277 |
| A | HOH596 |
| A | HOH601 |
| A | HOH603 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE MES B 502 |
| Chain | Residue |
| B | CYS111 |
| B | TYR143 |
| B | VAL196 |
| B | SER201 |
| B | HIS233 |
| B | PRO235 |
| B | ASN275 |
| B | TYR277 |
| B | SER308 |
| B | HOH531 |
| B | HOH605 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000250 |
| Chain | Residue | Details |
| A | GLU79 | |
| A | HIS233 | |
| B | GLU79 | |
| B | HIS233 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Acyl-thioester intermediate => ECO:0000269|PubMed:16245942 |
| Chain | Residue | Details |
| A | CYS111 | |
| B | CYS111 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | ASP29 | |
| A | SER201 | |
| A | ASN275 | |
| B | ASP29 | |
| B | SER201 | |
| B | ASN275 |
