2HCI
Structure of Human Mip-3a Chemokine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005125 | molecular_function | cytokine activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006935 | biological_process | chemotaxis |
| A | 0006954 | biological_process | inflammatory response |
| A | 0006955 | biological_process | immune response |
| A | 0007165 | biological_process | signal transduction |
| A | 0007267 | biological_process | cell-cell signaling |
| A | 0008009 | molecular_function | chemokine activity |
| A | 0019722 | biological_process | calcium-mediated signaling |
| A | 0031731 | molecular_function | CCR6 chemokine receptor binding |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0060326 | biological_process | cell chemotaxis |
| A | 0072678 | biological_process | T cell migration |
| A | 0072679 | biological_process | thymocyte migration |
| A | 2000406 | biological_process | positive regulation of T cell migration |
| B | 0005125 | molecular_function | cytokine activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0006935 | biological_process | chemotaxis |
| B | 0006954 | biological_process | inflammatory response |
| B | 0006955 | biological_process | immune response |
| B | 0007165 | biological_process | signal transduction |
| B | 0007267 | biological_process | cell-cell signaling |
| B | 0008009 | molecular_function | chemokine activity |
| B | 0019722 | biological_process | calcium-mediated signaling |
| B | 0031731 | molecular_function | CCR6 chemokine receptor binding |
| B | 0042742 | biological_process | defense response to bacterium |
| B | 0060326 | biological_process | cell chemotaxis |
| B | 0072678 | biological_process | T cell migration |
| B | 0072679 | biological_process | thymocyte migration |
| B | 2000406 | biological_process | positive regulation of T cell migration |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 301 |
| Chain | Residue |
| A | GLN53 |
| A | THR54 |
| A | TRP55 |
| B | HIS16 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO3 A 302 |
| Chain | Residue |
| A | HOH307 |
| A | HOH369 |
| A | ARG25 |
| A | GLN26 |
| A | LEU27 |
| A | GLU30 |
| A | CYS32 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO3 A 303 |
| Chain | Residue |
| A | ARG13 |
| A | LEU15 |
| A | TRP55 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO3 A 304 |
| Chain | Residue |
| A | ALA28 |
| A | GLY31 |
| A | CYS32 |
| A | ASP33 |
| A | HOH308 |
| A | HOH322 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO3 A 305 |
| Chain | Residue |
| A | LEU27 |
| A | ILE37 |
| A | PRO51 |
| B | LYS66 |
| B | VAL67 |
| B | HOH207 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG A 201 |
| Chain | Residue |
| A | LYS66 |
| A | VAL67 |
| A | ASN69 |
| B | LYS52 |
| B | LYS57 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG B 202 |
| Chain | Residue |
| A | LYS66 |
| B | GLN53 |
| B | THR54 |
| B | TRP55 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG B 203 |
| Chain | Residue |
| B | ASP5 |
| B | HIS16 |
| B | LYS18 |
| B | PHE19 |
| B | LYS42 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG A 204 |
| Chain | Residue |
| A | HOH350 |
| A | HOH368 |
| A | HOH371 |
| B | ARG13 |
| B | HOH252 |
Functional Information from PROSITE/UniProt
| site_id | PS00472 |
| Number of Residues | 44 |
| Details | SMALL_CYTOKINES_CC Small cytokines (intercrine/chemokine) C-C subfamily signature. CCLgytdri..LhpkfIvgFtrqlanegCdin.AIIFhtkkklsv.CA |
| Chain | Residue | Details |
| A | CYS6-ALA49 |
