2HC9

Structure of Caenorhabditis elegans leucine aminopeptidase-zinc complex (LAP1)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004177	molecular_function	aminopeptidase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0016787	molecular_function	hydrolase activity
A	0019538	biological_process	protein metabolic process
A	0030145	molecular_function	manganese ion binding
A	0040009	biological_process	regulation of growth rate
A	0042802	molecular_function	identical protein binding
A	0046662	biological_process	regulation of egg-laying behavior
A	0046872	molecular_function	metal ion binding
A	0070006	molecular_function	metalloaminopeptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN A 701

Chain	Residue
A	ASP257
A	ASP334
A	GLU336
A	ZN702
A	GOL1003
A	HOH2159

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ZN A 702

Chain	Residue
A	GLU336
A	ZN701
A	BCT801
A	HOH2159
A	LYS252
A	ASP257
A	ASP275

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE BCT A 801

Chain	Residue
A	LYS252
A	ALA335
A	GLU336
A	GLY337
A	ARG338
A	LEU363
A	ZN702
A	GOL1002
A	HOH2159

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 901

Chain	Residue
A	LYS98
A	ARG467
A	HOH2482
A	HOH2534
A	HOH2622

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 902

Chain	Residue
A	SER139
A	GLY140
A	ARG142
A	NA2001

---

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE NA A 2001

Chain	Residue
A	SO4902

---

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 1001

Chain	Residue
A	LYS326
A	MET421
A	ALA443
A	PHE447
A	HOH2555
A	HOH2619
A	HOH2637
A	HOH2657

---

site_id	AC8
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 1002

Chain	Residue
A	LYS266
A	ASN332
A	ASP334
A	THR364
A	GLY365
A	BCT801
A	GOL1003
A	GOL1015
A	HOH2043
A	HOH2460

---

site_id	AC9
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GOL A 1003

Chain	Residue
A	ASP257
A	LYS264
A	MET272
A	ASP275
A	THR362
A	LEU363
A	THR364
A	GLY365
A	ZN701
A	GOL1002
A	HOH2036
A	HOH2159
A	HOH2396

---

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 1004

Chain	Residue
A	LEU385
A	GLU388
A	ARG452
A	LEU479
A	LEU480
A	TYR483

---

site_id	BC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 1005

Chain	Residue
A	PHE114
A	ALA115
A	GLU116
A	VAL151
A	CYS152
A	ASP153
A	GOL1011
A	HOH2294

---

site_id	BC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 1006

Chain	Residue
A	LYS25
A	GLU116
A	PRO118
A	ASP119
A	HOH2225
A	HOH2293
A	HOH2380
A	HOH2616

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 1007

Chain	Residue
A	THR156
A	ASN157
A	GLU158
A	HOH2311
A	HOH2443

---

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 1008

Chain	Residue
A	GLY36
A	LYS39
A	HOH2461

---

site_id	BC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 1009

Chain	Residue
A	GOL1014
A	HOH2175
A	HOH2452
A	ARG7
A	ALA12
A	VAL13
A	GLY14
A	ASN145
A	ASN147

---

site_id	BC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 1010

Chain	Residue
A	ARG373
A	ASP430
A	GLU463
A	VAL464
A	GLY465
A	HOH2063
A	HOH2176
A	HOH2208
A	HOH2226
A	HOH2429

---

site_id	BC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1011

Chain	Residue
A	GLU116
A	TYR117
A	CYS152
A	ASP153
A	LYS154
A	GOL1005
A	HOH2383

---

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 1012

Chain	Residue
A	ASP187
A	ASP191
A	ARG208
A	GOL1014
A	HOH2423
A	HOH2426

---

site_id	CC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 1013

Chain	Residue
A	GLN11
A	ALA12
A	LYS37
A	HOH2330
A	HOH2600
A	HOH2659

---

site_id	CC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 1014

Chain	Residue
A	ASP191
A	VAL194
A	LYS195
A	GOL1009
A	GOL1012
A	HOH2089
A	HOH2213
A	HOH2305

---

site_id	CC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 1015

Chain	Residue
A	ASN332
A	ARG338
A	ALA366
A	SER424
A	PRO433
A	GOL1002
A	HOH2043
A	HOH2209
A	HOH2234

---

site_id	CC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 1016

Chain	Residue
A	THR138
A	SER324
A	LYS326
A	HOH2118
A	HOH2526

---

Functional Information from PROSITE/UniProt

site_id	PS00631
Number of Residues	8
Details	CYTOSOL_AP Cytosol aminopeptidase signature. NTDAEGRL

Chain	Residue	Details
A	ASN332-LEU339

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1lam

Chain	Residue	Details
A	ARG338
A	LYS264
A	ASP257

---