2HBU
Crystal structure of HIF prolyl hydroxylase EGLN-1 in complex with a biologically active inhibitor
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FE2 A 900 |
| Chain | Residue |
| A | UN91 |
| A | HIS313 |
| A | ASP315 |
| A | HIS374 |
| A | HOH993 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE UN9 A 1 |
| Chain | Residue |
| A | HIS313 |
| A | ASP315 |
| A | TYR329 |
| A | LEU343 |
| A | HIS374 |
| A | VAL376 |
| A | ARG383 |
| A | ARG398 |
| A | FE2900 |
| A | HOH921 |
| A | HOH993 |
| A | ASP254 |
| A | MET299 |
| A | TYR303 |
| A | TYR310 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16782814, ECO:0000269|PubMed:19604478, ECO:0000269|PubMed:28594552, ECO:0007744|PDB:2G19, ECO:0007744|PDB:3HQU, ECO:0007744|PDB:5V18 |
| Chain | Residue | Details |
| A | HIS313 | |
| A | ASP315 | |
| A | HIS374 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:19604478 |
| Chain | Residue | Details |
| A | ARG383 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | MOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:21601578 |
| Chain | Residue | Details |
| A | CYS201 | |
| A | CYS208 | |
| A | CYS302 | |
| A | CYS323 | |
| A | CYS326 |
