2HBJ
Structure of the yeast nuclear exosome component, Rrp6p, reveals an interplay between the active site and the HRDC domain
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000175 | molecular_function | 3'-5'-RNA exonuclease activity |
| A | 0000467 | biological_process | exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| A | 0008408 | molecular_function | 3'-5' exonuclease activity |
| A | 0044237 | biological_process | obsolete cellular metabolic process |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16882719, ECO:0007744|PDB:2HBL, ECO:0007744|PDB:2HBM |
| Chain | Residue | Details |
| A | ASP238 | |
| A | GLU240 | |
| A | ASP365 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16882719, ECO:0007744|PDB:2HBM |
| Chain | Residue | Details |
| A | HIS241 | |
| A | TRP299 | |
| A | LYS342 | |
| A | GLN345 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16882719, ECO:0007744|PDB:2HBK, ECO:0007744|PDB:2HBL, ECO:0007744|PDB:2HBM |
| Chain | Residue | Details |
| A | ASP296 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17330950 |
| Chain | Residue | Details |
| A | SER138 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18407956 |
| Chain | Residue | Details |
| A | THR520 |
