2HAL
An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004197 | molecular_function | cysteine-type endopeptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE BBL A 901 |
| Chain | Residue |
| A | ALA6 |
| A | HOH1035 |
| A | HOH1108 |
| A | HOH1291 |
| A | LEU8 |
| A | ARG10 |
| A | ARG97 |
| A | HIS102 |
| A | PRO127 |
| A | MET128 |
| A | LEU129 |
| A | HOH1017 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR CHAIN I OF N-ACETYL-LEUCYL-PHENYLALANYL-PHENYLALANYL-GLUTAMATE-FLUOROMETHYLKETONE INHIBITOR |
| Chain | Residue |
| A | GLU139 |
| A | VAL144 |
| A | HIS145 |
| A | LYS146 |
| A | ARG162 |
| A | GLY167 |
| A | LEU168 |
| A | PRO169 |
| A | GLY170 |
| A | MET171 |
| A | CYS172 |
| A | ALA193 |
| A | GLY194 |
| A | GLY195 |
| A | ASN196 |
| A | ILE198 |
| A | VAL200 |
| A | HOH973 |
| I | HOH72 |
| I | HOH301 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | Active site: {"description":"For protease 3C activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01222","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16288920","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
