2H9D
Pyruvate-Bound Structure of the Isochorismate-Pyruvate Lyase from Pseudomonas aerugionsa
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004106 | molecular_function | chorismate mutase activity |
| A | 0009697 | biological_process | salicylic acid biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016835 | molecular_function | carbon-oxygen lyase activity |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| A | 0042864 | biological_process | pyochelin biosynthetic process |
| A | 0043904 | molecular_function | isochorismate pyruvate lyase activity |
| A | 0046417 | biological_process | chorismate metabolic process |
| B | 0004106 | molecular_function | chorismate mutase activity |
| B | 0009697 | biological_process | salicylic acid biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016835 | molecular_function | carbon-oxygen lyase activity |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0042864 | biological_process | pyochelin biosynthetic process |
| B | 0043904 | molecular_function | isochorismate pyruvate lyase activity |
| B | 0046417 | biological_process | chorismate metabolic process |
| C | 0004106 | molecular_function | chorismate mutase activity |
| C | 0009697 | biological_process | salicylic acid biosynthetic process |
| C | 0016829 | molecular_function | lyase activity |
| C | 0016835 | molecular_function | carbon-oxygen lyase activity |
| C | 0016853 | molecular_function | isomerase activity |
| C | 0019752 | biological_process | carboxylic acid metabolic process |
| C | 0042864 | biological_process | pyochelin biosynthetic process |
| C | 0043904 | molecular_function | isochorismate pyruvate lyase activity |
| C | 0046417 | biological_process | chorismate metabolic process |
| D | 0004106 | molecular_function | chorismate mutase activity |
| D | 0009697 | biological_process | salicylic acid biosynthetic process |
| D | 0016829 | molecular_function | lyase activity |
| D | 0016835 | molecular_function | carbon-oxygen lyase activity |
| D | 0016853 | molecular_function | isomerase activity |
| D | 0019752 | biological_process | carboxylic acid metabolic process |
| D | 0042864 | biological_process | pyochelin biosynthetic process |
| D | 0043904 | molecular_function | isochorismate pyruvate lyase activity |
| D | 0046417 | biological_process | chorismate metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA D 301 |
| Chain | Residue |
| A | GLU15 |
| A | ASP18 |
| C | HOH238 |
| D | GLU15 |
| D | ASP18 |
| D | HOH343 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PYR C 201 |
| Chain | Residue |
| D | LYS42 |
| D | GLN90 |
| D | PYR202 |
| C | ARG14 |
| C | HOH211 |
| D | ALA38 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PYR D 202 |
| Chain | Residue |
| C | PYR201 |
| C | HOH211 |
| D | ARG31 |
| D | MET57 |
| D | TYR86 |
| D | ILE87 |
| D | GLN90 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PYR C 203 |
| Chain | Residue |
| C | ARG31 |
| C | ARG53 |
| C | MET57 |
| C | TYR86 |
| C | ILE87 |
| C | PYR206 |
| C | HOH249 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PYR B 204 |
| Chain | Residue |
| B | ARG31 |
| B | PRO49 |
| B | MET57 |
| B | ILE83 |
| B | GLN90 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PYR A 205 |
| Chain | Residue |
| A | ARG31 |
| A | VAL35 |
| A | MET57 |
| A | TYR86 |
| A | ILE87 |
| A | HOH214 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PYR C 206 |
| Chain | Residue |
| C | LYS42 |
| C | ARG53 |
| C | GLN90 |
| C | PYR203 |
| D | ARG14 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16914555","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21751784","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16914555","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19432488","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21751784","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 180 |
| Details | Domain: {"description":"Chorismate mutase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00515","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ecm |
| Chain | Residue | Details |
| A | ARG14 | |
| B | ARG31 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ecm |
| Chain | Residue | Details |
| A | ARG31 | |
| B | ARG14 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ecm |
| Chain | Residue | Details |
| C | ARG14 | |
| D | ARG31 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ecm |
| Chain | Residue | Details |
| C | ARG31 | |
| D | ARG14 |
