2H8S

Solution structure of alpha-conotoxin Vc1.1

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NH2 A 17

Chain	Residue
A	PRO13
A	ILE15
A	CYS16

---

Functional Information from PROSITE/UniProt

site_id	PS60014
Number of Residues	15
Details	ALPHA_CONOTOXIN Alpha-conotoxin family signature. CCSdPRCNydhpEIC

Chain	Residue	Details
A	CYS2-CYS16

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	15
Details	Peptide: {"description":"Alpha-conotoxin Vc1a","featureId":"PRO_0000034897","evidences":[{"source":"PubMed","id":"12779345","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Region: {"description":"Ser-Xaa-Pro motif, crucial for potent interaction with nAChR","evidences":[{"source":"UniProtKB","id":"P56636","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Region: {"description":"Key region for inhibition of alpha-9-alpha-10/CHRNA9-CHRNA10 nAChR","evidences":[{"source":"PubMed","id":"19447885","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"4-hydroxyproline","evidences":[{"source":"PubMed","id":"15170751","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"4-carboxyglutamate","evidences":[{"source":"PubMed","id":"15170751","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Cysteine amide","evidences":[{"source":"PubMed","id":"15170751","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---