2H8M

N-Domain Of Grp94 In Complex With the 2-Iodo-NECA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0006457	biological_process	protein folding
A	0016887	molecular_function	ATP hydrolysis activity
A	0051082	molecular_function	unfolded protein binding
A	0140662	molecular_function	ATP-dependent protein folding chaperone
B	0005524	molecular_function	ATP binding
B	0006457	biological_process	protein folding
B	0016887	molecular_function	ATP hydrolysis activity
B	0051082	molecular_function	unfolded protein binding
B	0140662	molecular_function	ATP-dependent protein folding chaperone

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE NEI A 401

Chain	Residue
A	ALA111
A	HOH524
A	HOH631
A	HOH689
A	ASP149
A	VAL152
A	GLY153
A	MET154
A	ASN162
A	LEU163
A	PHE199
A	HOH522

---

site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE NEI B 402

Chain	Residue
B	ALA111
B	ASP149
B	VAL152
B	GLY153
B	MET154
B	ASN162
B	LEU163
B	PHE199
B	HOH604
B	HOH605
B	HOH607
B	HOH608
B	HOH693
B	HOH699

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PG4 B 501

Chain	Residue
B	THR212
B	ARG237
B	HOH675
B	HOH720

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PG4 B 502

Chain	Residue
B	LYS137
B	HIS146
B	THR148
B	LEU241
B	HOH708

---

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PG4 A 504

Chain	Residue
A	THR212
A	ARG237
A	THR240
A	THR248
A	HOH534
A	HOH554
A	HOH585
A	HOH651
A	HOH686

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PG4 A 505

Chain	Residue
A	LYS137
A	HIS146
A	TRP282
A	HOH590
A	HOH597

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PG4 A 506

Chain	Residue
A	ASN162
A	HOH668

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PG4 A 507

Chain	Residue
A	ASP110
A	ASP113
A	LYS114
A	LEU117

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PG4 B 508

Chain	Residue
B	ASN107
B	ALA108
B	ASP149

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PG4 B 509

Chain	Residue
B	ASP110
B	LYS114
B	LEU117
B	HOH711

---

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PG4 A 510

Chain	Residue
A	THR263
A	ASN266

---

site_id	BC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 1PE B 601

Chain	Residue
A	ASN83
A	LYS87
A	ILE90
A	SER227
B	ASN83
B	LYS87
B	ILE90
B	SER227

---

site_id	BC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 1PE B 602

Chain	Residue
A	LYS75
A	ALA77
A	PHE78
B	LYS75
B	PHE76
B	ALA77
B	HOH724

---

Functional Information from PROSITE/UniProt

site_id	PS00298
Number of Residues	10
Details	HSP90 Heat shock hsp90 proteins family signature. YkNKEIFLRE

Chain	Residue	Details
A	TYR94-GLU103

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:15292259, ECO:0000269|PubMed:15951571, ECO:0000269|PubMed:17936703, ECO:0007744|PDB:1TC0, ECO:0007744|PDB:1TC6, ECO:0007744|PDB:1YT0, ECO:0007744|PDB:2O1U, ECO:0007744|PDB:2O1V

Chain	Residue	Details
A	ASN107
B	ASN107

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:15292259, ECO:0000269|PubMed:15951571, ECO:0000269|PubMed:17936703, ECO:0007744|PDB:1TBW, ECO:0007744|PDB:1TC0, ECO:0007744|PDB:1TC6, ECO:0007744|PDB:1YT0, ECO:0007744|PDB:2O1U, ECO:0007744|PDB:2O1V

Chain	Residue	Details
A	ASP149
A	PHE199
B	ASP149
B	PHE199

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:15292259, ECO:0000269|PubMed:15951571, ECO:0000269|PubMed:17936703, ECO:0007744|PDB:1TBW, ECO:0007744|PDB:1TC0, ECO:0007744|PDB:1TC6, ECO:0007744|PDB:2O1U, ECO:0007744|PDB:2O1V

Chain	Residue	Details
A	ASN162
B	ASN162

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-(2-hydroxyisobutyryl)lysine => ECO:0000250|UniProtKB:P14625

Chain	Residue	Details
A	LYS168
B	LYS168

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q66HD0

Chain	Residue	Details
A	SER172
B	SER172

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by CK2 => ECO:0000255

Chain	Residue	Details
A	GLY288
B	GLY288

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphoserine; by CK2 => ECO:0000250|UniProtKB:P14625, ECO:0000255

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN107
A	ASN217
B	ASN107
B	ASN217

---