2H63

Crystal Structure of Human Biliverdin Reductase A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004074	molecular_function	biliverdin reductase [NAD(P)H] activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006631	biological_process	fatty acid metabolic process
A	0006641	biological_process	triglyceride metabolic process
A	0006935	biological_process	chemotaxis
A	0006954	biological_process	inflammatory response
A	0006979	biological_process	response to oxidative stress
A	0008270	molecular_function	zinc ion binding
A	0010467	biological_process	gene expression
A	0016491	molecular_function	oxidoreductase activity
A	0032094	biological_process	response to food
A	0032496	biological_process	response to lipopolysaccharide
A	0034440	biological_process	lipid oxidation
A	0038178	biological_process	complement component C5a signaling pathway
A	0042167	biological_process	heme catabolic process
A	0042440	biological_process	pigment metabolic process
A	0046872	molecular_function	metal ion binding
A	0070062	cellular_component	extracellular exosome
A	0106276	molecular_function	biliberdin reductase (NADH) activity
A	0106277	molecular_function	biliverdin reductase (NADPH) activity
A	0160025	biological_process	sensory perception of itch
A	1905237	biological_process	response to cyclosporin A
B	0000166	molecular_function	nucleotide binding
B	0004074	molecular_function	biliverdin reductase [NAD(P)H] activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006631	biological_process	fatty acid metabolic process
B	0006641	biological_process	triglyceride metabolic process
B	0006935	biological_process	chemotaxis
B	0006954	biological_process	inflammatory response
B	0006979	biological_process	response to oxidative stress
B	0008270	molecular_function	zinc ion binding
B	0010467	biological_process	gene expression
B	0016491	molecular_function	oxidoreductase activity
B	0032094	biological_process	response to food
B	0032496	biological_process	response to lipopolysaccharide
B	0034440	biological_process	lipid oxidation
B	0038178	biological_process	complement component C5a signaling pathway
B	0042167	biological_process	heme catabolic process
B	0042440	biological_process	pigment metabolic process
B	0046872	molecular_function	metal ion binding
B	0070062	cellular_component	extracellular exosome
B	0106276	molecular_function	biliberdin reductase (NADH) activity
B	0106277	molecular_function	biliverdin reductase (NADPH) activity
B	0160025	biological_process	sensory perception of itch
B	1905237	biological_process	response to cyclosporin A
C	0000166	molecular_function	nucleotide binding
C	0004074	molecular_function	biliverdin reductase [NAD(P)H] activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006631	biological_process	fatty acid metabolic process
C	0006641	biological_process	triglyceride metabolic process
C	0006935	biological_process	chemotaxis
C	0006954	biological_process	inflammatory response
C	0006979	biological_process	response to oxidative stress
C	0008270	molecular_function	zinc ion binding
C	0010467	biological_process	gene expression
C	0016491	molecular_function	oxidoreductase activity
C	0032094	biological_process	response to food
C	0032496	biological_process	response to lipopolysaccharide
C	0034440	biological_process	lipid oxidation
C	0038178	biological_process	complement component C5a signaling pathway
C	0042167	biological_process	heme catabolic process
C	0042440	biological_process	pigment metabolic process
C	0046872	molecular_function	metal ion binding
C	0070062	cellular_component	extracellular exosome
C	0106276	molecular_function	biliberdin reductase (NADH) activity
C	0106277	molecular_function	biliverdin reductase (NADPH) activity
C	0160025	biological_process	sensory perception of itch
C	1905237	biological_process	response to cyclosporin A
D	0000166	molecular_function	nucleotide binding
D	0004074	molecular_function	biliverdin reductase [NAD(P)H] activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006631	biological_process	fatty acid metabolic process
D	0006641	biological_process	triglyceride metabolic process
D	0006935	biological_process	chemotaxis
D	0006954	biological_process	inflammatory response
D	0006979	biological_process	response to oxidative stress
D	0008270	molecular_function	zinc ion binding
D	0010467	biological_process	gene expression
D	0016491	molecular_function	oxidoreductase activity
D	0032094	biological_process	response to food
D	0032496	biological_process	response to lipopolysaccharide
D	0034440	biological_process	lipid oxidation
D	0038178	biological_process	complement component C5a signaling pathway
D	0042167	biological_process	heme catabolic process
D	0042440	biological_process	pigment metabolic process
D	0046872	molecular_function	metal ion binding
D	0070062	cellular_component	extracellular exosome
D	0106276	molecular_function	biliberdin reductase (NADH) activity
D	0106277	molecular_function	biliverdin reductase (NADPH) activity
D	0160025	biological_process	sensory perception of itch
D	1905237	biological_process	response to cyclosporin A

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE NAP A 501

Chain	Residue
A	GLY15
A	SER75
A	SER77
A	HIS80
A	GLU97
A	TYR98
A	PHE162
D	SER235
A	VAL16
A	GLY17
A	ARG18
A	ALA19
A	SER44
A	ARG45
A	ARG46
A	CYS74

---

site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE NAP B 501

Chain	Residue
B	GLY15
B	VAL16
B	GLY17
B	ARG18
B	ALA19
B	SER44
B	ARG45
B	ARG46
B	CYS74
B	SER75
B	SER77
B	HIS80
B	GLU97
B	TYR98
B	PHE162
B	PHE251

---

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE NAP C 501

Chain	Residue
C	GLY15
C	VAL16
C	GLY17
C	ARG18
C	ALA19
C	SER44
C	ARG45
C	ARG46
C	CYS74
C	SER75
C	SER77
C	HIS80
C	GLU97
C	TYR98
C	GLU124

---

site_id	AC4
Number of Residues	19
Details	BINDING SITE FOR RESIDUE NAP D 501

Chain	Residue
A	ARG7
C	SER235
D	GLY15
D	VAL16
D	GLY17
D	ARG18
D	ALA19
D	SER44
D	ARG45
D	ARG46
D	CYS74
D	SER75
D	SER77
D	HIS80
D	GLU97
D	TYR98
D	GLU124
D	PHE162
D	HOH507

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269|Ref.19, ECO:0007744|PDB:2H63

Chain	Residue	Details
A	VAL16
C	SER44
C	SER77
C	TYR98
D	VAL16
D	SER44
D	SER77
D	TYR98
A	SER44
A	SER77
A	TYR98
B	VAL16
B	SER44
B	SER77
B	TYR98
C	VAL16

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000303|PubMed:8631357

Chain	Residue	Details
A	HIS280
C	CYS281
C	CYS292
C	CYS293
D	HIS280
D	CYS281
D	CYS292
D	CYS293
A	CYS281
A	CYS292
A	CYS293
B	HIS280
B	CYS281
B	CYS292
B	CYS293
C	HIS280

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332

Chain	Residue	Details
A	THR174
B	THR174
C	THR174
D	THR174

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332

Chain	Residue	Details
A	SER178
B	SER178
C	SER178
D	SER178

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
A	SER230
B	SER230
C	SER230
D	SER230

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS248
A	LYS253
B	LYS248
B	LYS253
C	LYS248
C	LYS253
D	LYS248
D	LYS253

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	6
Details	Annotated By Reference To The Literature 1gcu

Chain	Residue	Details
A	ARG172
A	GLU97
A	TYR98
A	GLU124
A	GLU127
A	SER171

---

site_id	CSA2
Number of Residues	6
Details	Annotated By Reference To The Literature 1gcu

Chain	Residue	Details
B	ARG172
B	GLU97
B	TYR98
B	GLU124
B	GLU127
B	SER171

---

site_id	CSA3
Number of Residues	6
Details	Annotated By Reference To The Literature 1gcu

Chain	Residue	Details
C	ARG172
C	GLU97
C	TYR98
C	GLU124
C	GLU127
C	SER171

---

site_id	CSA4
Number of Residues	6
Details	Annotated By Reference To The Literature 1gcu

Chain	Residue	Details
D	ARG172
D	GLU97
D	TYR98
D	GLU124
D	GLU127
D	SER171

---