Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2H63

Crystal Structure of Human Biliverdin Reductase A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
A	0004074	molecular_function	biliverdin reductase [NAD(P)H] activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0008270	molecular_function	zinc ion binding
A	0009986	cellular_component	cell surface
A	0016491	molecular_function	oxidoreductase activity
A	0042167	biological_process	heme catabolic process
A	0046872	molecular_function	metal ion binding
A	0070062	cellular_component	extracellular exosome
A	0106276	molecular_function	biliberdin reductase (NADH) activity
A	0106277	molecular_function	biliverdin reductase (NADPH) activity
B	0000166	molecular_function	nucleotide binding
B	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
B	0004074	molecular_function	biliverdin reductase [NAD(P)H] activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0008270	molecular_function	zinc ion binding
B	0009986	cellular_component	cell surface
B	0016491	molecular_function	oxidoreductase activity
B	0042167	biological_process	heme catabolic process
B	0046872	molecular_function	metal ion binding
B	0070062	cellular_component	extracellular exosome
B	0106276	molecular_function	biliberdin reductase (NADH) activity
B	0106277	molecular_function	biliverdin reductase (NADPH) activity
C	0000166	molecular_function	nucleotide binding
C	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
C	0004074	molecular_function	biliverdin reductase [NAD(P)H] activity
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0008270	molecular_function	zinc ion binding
C	0009986	cellular_component	cell surface
C	0016491	molecular_function	oxidoreductase activity
C	0042167	biological_process	heme catabolic process
C	0046872	molecular_function	metal ion binding
C	0070062	cellular_component	extracellular exosome
C	0106276	molecular_function	biliberdin reductase (NADH) activity
C	0106277	molecular_function	biliverdin reductase (NADPH) activity
D	0000166	molecular_function	nucleotide binding
D	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
D	0004074	molecular_function	biliverdin reductase [NAD(P)H] activity
D	0004674	molecular_function	protein serine/threonine kinase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0008270	molecular_function	zinc ion binding
D	0009986	cellular_component	cell surface
D	0016491	molecular_function	oxidoreductase activity
D	0042167	biological_process	heme catabolic process
D	0046872	molecular_function	metal ion binding
D	0070062	cellular_component	extracellular exosome
D	0106276	molecular_function	biliberdin reductase (NADH) activity
D	0106277	molecular_function	biliverdin reductase (NADPH) activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE NAP A 501

Chain	Residue
A	GLY15
A	SER75
A	SER77
A	HIS80
A	GLU97
A	TYR98
A	PHE162
D	SER235
A	VAL16
A	GLY17
A	ARG18
A	ALA19
A	SER44
A	ARG45
A	ARG46
A	CYS74

site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE NAP B 501

Chain	Residue
B	GLY15
B	VAL16
B	GLY17
B	ARG18
B	ALA19
B	SER44
B	ARG45
B	ARG46
B	CYS74
B	SER75
B	SER77
B	HIS80
B	GLU97
B	TYR98
B	PHE162
B	PHE251

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE NAP C 501

Chain	Residue
C	GLY15
C	VAL16
C	GLY17
C	ARG18
C	ALA19
C	SER44
C	ARG45
C	ARG46
C	CYS74
C	SER75
C	SER77
C	HIS80
C	GLU97
C	TYR98
C	GLU124

site_id	AC4
Number of Residues	19
Details	BINDING SITE FOR RESIDUE NAP D 501

Chain	Residue
A	ARG7
C	SER235
D	GLY15
D	VAL16
D	GLY17
D	ARG18
D	ALA19
D	SER44
D	ARG45
D	ARG46
D	CYS74
D	SER75
D	SER77
D	HIS80
D	GLU97
D	TYR98
D	GLU124
D	PHE162
D	HOH507

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of human biliverdin reductase A.","authoringGroup":["Structural genomics consortium (SGC)"]}},{"source":"PDB","id":"2H63","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"8631357","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	6
Details	Annotated By Reference To The Literature 1gcu

Chain	Residue	Details
A	ARG172
A	GLU97
A	TYR98
A	GLU124
A	GLU127
A	SER171

site_id	CSA2
Number of Residues	6
Details	Annotated By Reference To The Literature 1gcu

Chain	Residue	Details
B	ARG172
B	GLU97
B	TYR98
B	GLU124
B	GLU127
B	SER171

site_id	CSA3
Number of Residues	6
Details	Annotated By Reference To The Literature 1gcu

Chain	Residue	Details
C	ARG172
C	GLU97
C	TYR98
C	GLU124
C	GLU127
C	SER171

site_id	CSA4
Number of Residues	6
Details	Annotated By Reference To The Literature 1gcu

Chain	Residue	Details
D	ARG172
D	GLU97
D	TYR98
D	GLU124
D	GLU127
D	SER171

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)