2H61

X-ray structure of human Ca2+-loaded S100B

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001726	cellular_component	ruffle
A	0005102	molecular_function	signaling receptor binding
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0007155	biological_process	cell adhesion
A	0007409	biological_process	axonogenesis
A	0007417	biological_process	central nervous system development
A	0007611	biological_process	learning or memory
A	0008270	molecular_function	zinc ion binding
A	0008284	biological_process	positive regulation of cell population proliferation
A	0008360	biological_process	regulation of cell shape
A	0031643	biological_process	positive regulation of myelination
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0043025	cellular_component	neuronal cell body
A	0043065	biological_process	positive regulation of apoptotic process
A	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
A	0044548	molecular_function	S100 protein binding
A	0045471	biological_process	response to ethanol
A	0045666	biological_process	positive regulation of neuron differentiation
A	0046872	molecular_function	metal ion binding
A	0048156	molecular_function	tau protein binding
A	0048306	molecular_function	calcium-dependent protein binding
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0048708	biological_process	astrocyte differentiation
A	0050786	molecular_function	RAGE receptor binding
A	0050806	biological_process	positive regulation of synaptic transmission
A	0051384	biological_process	response to glucocorticoid
A	0051597	biological_process	response to methylmercury
A	0060291	biological_process	long-term synaptic potentiation
A	0071456	biological_process	cellular response to hypoxia
A	0072347	biological_process	response to anesthetic
A	0097490	biological_process	sympathetic neuron projection extension
A	1990138	biological_process	neuron projection extension
A	1990845	biological_process	adaptive thermogenesis
A	2001015	biological_process	negative regulation of skeletal muscle cell differentiation
B	0001726	cellular_component	ruffle
B	0005102	molecular_function	signaling receptor binding
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0007155	biological_process	cell adhesion
B	0007409	biological_process	axonogenesis
B	0007417	biological_process	central nervous system development
B	0007611	biological_process	learning or memory
B	0008270	molecular_function	zinc ion binding
B	0008284	biological_process	positive regulation of cell population proliferation
B	0008360	biological_process	regulation of cell shape
B	0031643	biological_process	positive regulation of myelination
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0043025	cellular_component	neuronal cell body
B	0043065	biological_process	positive regulation of apoptotic process
B	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
B	0044548	molecular_function	S100 protein binding
B	0045471	biological_process	response to ethanol
B	0045666	biological_process	positive regulation of neuron differentiation
B	0046872	molecular_function	metal ion binding
B	0048156	molecular_function	tau protein binding
B	0048306	molecular_function	calcium-dependent protein binding
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0048708	biological_process	astrocyte differentiation
B	0050786	molecular_function	RAGE receptor binding
B	0050806	biological_process	positive regulation of synaptic transmission
B	0051384	biological_process	response to glucocorticoid
B	0051597	biological_process	response to methylmercury
B	0060291	biological_process	long-term synaptic potentiation
B	0071456	biological_process	cellular response to hypoxia
B	0072347	biological_process	response to anesthetic
B	0097490	biological_process	sympathetic neuron projection extension
B	1990138	biological_process	neuron projection extension
B	1990845	biological_process	adaptive thermogenesis
B	2001015	biological_process	negative regulation of skeletal muscle cell differentiation
C	0001726	cellular_component	ruffle
C	0005102	molecular_function	signaling receptor binding
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0007155	biological_process	cell adhesion
C	0007409	biological_process	axonogenesis
C	0007417	biological_process	central nervous system development
C	0007611	biological_process	learning or memory
C	0008270	molecular_function	zinc ion binding
C	0008284	biological_process	positive regulation of cell population proliferation
C	0008360	biological_process	regulation of cell shape
C	0031643	biological_process	positive regulation of myelination
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0043025	cellular_component	neuronal cell body
C	0043065	biological_process	positive regulation of apoptotic process
C	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
C	0044548	molecular_function	S100 protein binding
C	0045471	biological_process	response to ethanol
C	0045666	biological_process	positive regulation of neuron differentiation
C	0046872	molecular_function	metal ion binding
C	0048156	molecular_function	tau protein binding
C	0048306	molecular_function	calcium-dependent protein binding
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0048708	biological_process	astrocyte differentiation
C	0050786	molecular_function	RAGE receptor binding
C	0050806	biological_process	positive regulation of synaptic transmission
C	0051384	biological_process	response to glucocorticoid
C	0051597	biological_process	response to methylmercury
C	0060291	biological_process	long-term synaptic potentiation
C	0071456	biological_process	cellular response to hypoxia
C	0072347	biological_process	response to anesthetic
C	0097490	biological_process	sympathetic neuron projection extension
C	1990138	biological_process	neuron projection extension
C	1990845	biological_process	adaptive thermogenesis
C	2001015	biological_process	negative regulation of skeletal muscle cell differentiation
D	0001726	cellular_component	ruffle
D	0005102	molecular_function	signaling receptor binding
D	0005509	molecular_function	calcium ion binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0007155	biological_process	cell adhesion
D	0007409	biological_process	axonogenesis
D	0007417	biological_process	central nervous system development
D	0007611	biological_process	learning or memory
D	0008270	molecular_function	zinc ion binding
D	0008284	biological_process	positive regulation of cell population proliferation
D	0008360	biological_process	regulation of cell shape
D	0031643	biological_process	positive regulation of myelination
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0043025	cellular_component	neuronal cell body
D	0043065	biological_process	positive regulation of apoptotic process
D	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
D	0044548	molecular_function	S100 protein binding
D	0045471	biological_process	response to ethanol
D	0045666	biological_process	positive regulation of neuron differentiation
D	0046872	molecular_function	metal ion binding
D	0048156	molecular_function	tau protein binding
D	0048306	molecular_function	calcium-dependent protein binding
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0048708	biological_process	astrocyte differentiation
D	0050786	molecular_function	RAGE receptor binding
D	0050806	biological_process	positive regulation of synaptic transmission
D	0051384	biological_process	response to glucocorticoid
D	0051597	biological_process	response to methylmercury
D	0060291	biological_process	long-term synaptic potentiation
D	0071456	biological_process	cellular response to hypoxia
D	0072347	biological_process	response to anesthetic
D	0097490	biological_process	sympathetic neuron projection extension
D	1990138	biological_process	neuron projection extension
D	1990845	biological_process	adaptive thermogenesis
D	2001015	biological_process	negative regulation of skeletal muscle cell differentiation
E	0001726	cellular_component	ruffle
E	0005102	molecular_function	signaling receptor binding
E	0005509	molecular_function	calcium ion binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0007155	biological_process	cell adhesion
E	0007409	biological_process	axonogenesis
E	0007417	biological_process	central nervous system development
E	0007611	biological_process	learning or memory
E	0008270	molecular_function	zinc ion binding
E	0008284	biological_process	positive regulation of cell population proliferation
E	0008360	biological_process	regulation of cell shape
E	0031643	biological_process	positive regulation of myelination
E	0042802	molecular_function	identical protein binding
E	0042803	molecular_function	protein homodimerization activity
E	0043025	cellular_component	neuronal cell body
E	0043065	biological_process	positive regulation of apoptotic process
E	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
E	0044548	molecular_function	S100 protein binding
E	0045471	biological_process	response to ethanol
E	0045666	biological_process	positive regulation of neuron differentiation
E	0046872	molecular_function	metal ion binding
E	0048156	molecular_function	tau protein binding
E	0048306	molecular_function	calcium-dependent protein binding
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0048708	biological_process	astrocyte differentiation
E	0050786	molecular_function	RAGE receptor binding
E	0050806	biological_process	positive regulation of synaptic transmission
E	0051384	biological_process	response to glucocorticoid
E	0051597	biological_process	response to methylmercury
E	0060291	biological_process	long-term synaptic potentiation
E	0071456	biological_process	cellular response to hypoxia
E	0072347	biological_process	response to anesthetic
E	0097490	biological_process	sympathetic neuron projection extension
E	1990138	biological_process	neuron projection extension
E	1990845	biological_process	adaptive thermogenesis
E	2001015	biological_process	negative regulation of skeletal muscle cell differentiation
F	0001726	cellular_component	ruffle
F	0005102	molecular_function	signaling receptor binding
F	0005509	molecular_function	calcium ion binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0007155	biological_process	cell adhesion
F	0007409	biological_process	axonogenesis
F	0007417	biological_process	central nervous system development
F	0007611	biological_process	learning or memory
F	0008270	molecular_function	zinc ion binding
F	0008284	biological_process	positive regulation of cell population proliferation
F	0008360	biological_process	regulation of cell shape
F	0031643	biological_process	positive regulation of myelination
F	0042802	molecular_function	identical protein binding
F	0042803	molecular_function	protein homodimerization activity
F	0043025	cellular_component	neuronal cell body
F	0043065	biological_process	positive regulation of apoptotic process
F	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
F	0044548	molecular_function	S100 protein binding
F	0045471	biological_process	response to ethanol
F	0045666	biological_process	positive regulation of neuron differentiation
F	0046872	molecular_function	metal ion binding
F	0048156	molecular_function	tau protein binding
F	0048306	molecular_function	calcium-dependent protein binding
F	0048471	cellular_component	perinuclear region of cytoplasm
F	0048708	biological_process	astrocyte differentiation
F	0050786	molecular_function	RAGE receptor binding
F	0050806	biological_process	positive regulation of synaptic transmission
F	0051384	biological_process	response to glucocorticoid
F	0051597	biological_process	response to methylmercury
F	0060291	biological_process	long-term synaptic potentiation
F	0071456	biological_process	cellular response to hypoxia
F	0072347	biological_process	response to anesthetic
F	0097490	biological_process	sympathetic neuron projection extension
F	1990138	biological_process	neuron projection extension
F	1990845	biological_process	adaptive thermogenesis
F	2001015	biological_process	negative regulation of skeletal muscle cell differentiation
G	0001726	cellular_component	ruffle
G	0005102	molecular_function	signaling receptor binding
G	0005509	molecular_function	calcium ion binding
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0007155	biological_process	cell adhesion
G	0007409	biological_process	axonogenesis
G	0007417	biological_process	central nervous system development
G	0007611	biological_process	learning or memory
G	0008270	molecular_function	zinc ion binding
G	0008284	biological_process	positive regulation of cell population proliferation
G	0008360	biological_process	regulation of cell shape
G	0031643	biological_process	positive regulation of myelination
G	0042802	molecular_function	identical protein binding
G	0042803	molecular_function	protein homodimerization activity
G	0043025	cellular_component	neuronal cell body
G	0043065	biological_process	positive regulation of apoptotic process
G	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
G	0044548	molecular_function	S100 protein binding
G	0045471	biological_process	response to ethanol
G	0045666	biological_process	positive regulation of neuron differentiation
G	0046872	molecular_function	metal ion binding
G	0048156	molecular_function	tau protein binding
G	0048306	molecular_function	calcium-dependent protein binding
G	0048471	cellular_component	perinuclear region of cytoplasm
G	0048708	biological_process	astrocyte differentiation
G	0050786	molecular_function	RAGE receptor binding
G	0050806	biological_process	positive regulation of synaptic transmission
G	0051384	biological_process	response to glucocorticoid
G	0051597	biological_process	response to methylmercury
G	0060291	biological_process	long-term synaptic potentiation
G	0071456	biological_process	cellular response to hypoxia
G	0072347	biological_process	response to anesthetic
G	0097490	biological_process	sympathetic neuron projection extension
G	1990138	biological_process	neuron projection extension
G	1990845	biological_process	adaptive thermogenesis
G	2001015	biological_process	negative regulation of skeletal muscle cell differentiation
H	0001726	cellular_component	ruffle
H	0005102	molecular_function	signaling receptor binding
H	0005509	molecular_function	calcium ion binding
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0007155	biological_process	cell adhesion
H	0007409	biological_process	axonogenesis
H	0007417	biological_process	central nervous system development
H	0007611	biological_process	learning or memory
H	0008270	molecular_function	zinc ion binding
H	0008284	biological_process	positive regulation of cell population proliferation
H	0008360	biological_process	regulation of cell shape
H	0031643	biological_process	positive regulation of myelination
H	0042802	molecular_function	identical protein binding
H	0042803	molecular_function	protein homodimerization activity
H	0043025	cellular_component	neuronal cell body
H	0043065	biological_process	positive regulation of apoptotic process
H	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
H	0044548	molecular_function	S100 protein binding
H	0045471	biological_process	response to ethanol
H	0045666	biological_process	positive regulation of neuron differentiation
H	0046872	molecular_function	metal ion binding
H	0048156	molecular_function	tau protein binding
H	0048306	molecular_function	calcium-dependent protein binding
H	0048471	cellular_component	perinuclear region of cytoplasm
H	0048708	biological_process	astrocyte differentiation
H	0050786	molecular_function	RAGE receptor binding
H	0050806	biological_process	positive regulation of synaptic transmission
H	0051384	biological_process	response to glucocorticoid
H	0051597	biological_process	response to methylmercury
H	0060291	biological_process	long-term synaptic potentiation
H	0071456	biological_process	cellular response to hypoxia
H	0072347	biological_process	response to anesthetic
H	0097490	biological_process	sympathetic neuron projection extension
H	1990138	biological_process	neuron projection extension
H	1990845	biological_process	adaptive thermogenesis
H	2001015	biological_process	negative regulation of skeletal muscle cell differentiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 801

Chain	Residue
A	SER18
A	GLU21
A	ASP23
A	LYS26
A	GLU31
A	HOH804

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 802

Chain	Residue
A	GLU67
A	GLU72
A	HOH805
A	ASP61
A	ASP63
A	ASP65

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 803

Chain	Residue
B	SER18
B	GLU21
B	ASP23
B	LYS26
B	GLU31
B	HOH807

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 804

Chain	Residue
B	ASP61
B	ASP63
B	ASP65
B	GLU67
B	GLU72
B	HOH839

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 805

Chain	Residue
C	SER18
C	GLU21
C	ASP23
C	LYS26
C	GLU31
C	HOH812

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 806

Chain	Residue
C	ASP61
C	ASP63
C	ASP65
C	GLU67
C	GLU72
C	HOH809

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA D 807

Chain	Residue
D	SER18
D	GLU21
D	ASP23
D	LYS26
D	GLU31
D	HOH820

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA D 808

Chain	Residue
D	ASP61
D	ASP63
D	ASP65
D	GLU67
D	GLU72
D	HOH821

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA D 817

Chain	Residue
D	ASP12
D	HOH822
D	HOH823
E	SER41
E	LEU44
E	HOH904

---

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 809

Chain	Residue
E	SER18
E	GLU21
E	ASP23
E	LYS26
E	GLU31
E	HOH902

---

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 810

Chain	Residue
E	ASP61
E	ASP63
E	ASP65
E	GLU67
E	GLU72
E	HOH903

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA F 811

Chain	Residue
F	SER18
F	GLU21
F	ASP23
F	LYS26
F	GLU31
F	HOH814

---

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA F 812

Chain	Residue
F	ASP61
F	ASP63
F	ASP65
F	GLU67
F	GLU72
F	HOH874

---

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA G 813

Chain	Residue
G	SER18
G	GLU21
G	ASP23
G	LYS26
G	GLU31
G	HOH851

---

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA G 814

Chain	Residue
G	ASP61
G	ASP63
G	ASP65
G	GLU67
G	GLU72
G	HOH820

---

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA G 818

Chain	Residue
B	SER41
B	HOH805
B	HOH806
G	ASP12
G	HOH819

---

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA H 815

Chain	Residue
H	GLU31
H	HOH820
H	SER18
H	GLU21
H	ASP23
H	LYS26

---

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA H 816

Chain	Residue
H	ASP61
H	ASP63
H	ASP65
H	GLU67
H	GLU72
H	HOH818

---

site_id	CC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PG4 E 901

Chain	Residue
C	PHE88
D	ILE11
D	ASP12
D	HIS15
E	HIS42
E	PHE43
E	ALA83
E	PHE87
E	HOH964

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DNDGDGECDfqEF

Chain	Residue	Details
A	ASP61-PHE73
C	ASP61-PHE73

---

site_id	PS00303
Number of Residues	22
Details	S100_CABP S-100/ICaBP type calcium binding protein signature. VMetLDndgDgecDFqEFmaFV

Chain	Residue	Details
A	VAL56-VAL77
C	VAL56-VAL77

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	280
Details	Domain: {"description":"EF-hand 1","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	280
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	28
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20950652","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3CZT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	40
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20950652","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3CZT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3D0Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3D10","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20950652","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3CZT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3D0Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3D10","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20950652","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2H61","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CZT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3D0Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3D10","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	Modified residue: {"description":"N-acetylserine; alternate","evidences":[{"source":"UniProtKB","id":"P02638","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---