Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SO4 A 246 |
| Chain | Residue |
| A | ALA15 |
| A | HOH398 |
| A | HOH407 |
| A | ASN15 |
| A | ARG230 |
| A | PRO233 |
| A | HOH309 |
| A | HOH334 |
| A | HOH339 |
| A | HOH374 |
| A | HOH379 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 208 |
| Chain | Residue |
| A | ALA169 |
| A | ASN170 |
| B | MSU199 |
| B | ALA200 |
| B | HOH409 |
| B | HOH602 |
| B | HOH711 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 247 |
| Chain | Residue |
| A | ARG90 |
| A | HOH318 |
| A | HOH372 |
| A | HOH377 |
| A | HOH480 |
| A | HOH603 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE SO4 A 248 |
| Chain | Residue |
| A | LEU41 |
| A | THR125 |
| A | ARG141 |
| A | SO4249 |
| A | HOH324 |
| A | HOH357 |
| A | HOH566 |
| A | HOH593 |
| A | HOH616 |
| A | HOH617 |
| A | HOH623 |
| A | HOH640 |
| A | HOH649 |
| A | HOH705 |
| A | HOH719 |
| site_id | AC5 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE SO4 A 249 |
| Chain | Residue |
| A | SER120 |
| A | GLY123 |
| A | SER124 |
| A | THR125 |
| A | ARG192 |
| A | SO4248 |
| A | HOH332 |
| A | HOH343 |
| A | HOH357 |
| A | HOH578 |
| A | HOH616 |
| A | HOH625 |
| A | HOH641 |
| A | HOH649 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 250 |
| Chain | Residue |
| A | THR168 |
| A | ARG178 |
| A | HOH415 |
| A | HOH513 |
| A | HOH646 |
| A | HOH650 |
| A | HOH706 |
| site_id | AC7 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE SO4 A 251 |
| Chain | Residue |
| A | ALA48 |
| A | THR49 |
| A | SER110 |
| A | ALA176 |
| A | ARG178 |
| A | HOH323 |
| A | HOH344 |
| A | HOH361 |
| A | HOH463 |
| A | HOH599 |
| A | HOH613 |
| A | HOH658 |
| A | HOH707 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 252 |
| Chain | Residue |
| A | ALA131 |
| A | VAL132 |
| A | LYS165 |
| A | HOH472 |
| A | HOH533 |
| A | HOH591 |
| A | HOH609 |
| A | HOH670 |
| site_id | AC9 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE GOL B 204 |
| Chain | Residue |
| A | LEU41 |
| A | CYS42 |
| A | HIS57 |
| A | GLY193 |
| A | SER195 |
| A | GLN208 |
| A | HOH393 |
| A | HOH520 |
| A | HOH582 |
| A | HOH642 |
| B | PRO202 |
| B | B2V203 |
| B | HOH378 |
| B | HOH519 |
| B | HOH589 |
| B | HOH654 |
| site_id | BC1 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR CHAIN B OF MEOSUC-ALA-ALA-PRO-ALA BORONIC ACID INHIBITOR |
| Chain | Residue |
| A | TYR171 |
| A | GLY191 |
| A | GLY193 |
| A | ASP194 |
| A | SER195 |
| A | MET213 |
| A | SER214 |
| A | GLY215 |
| A | GLY216 |
| A | ASN217 |
| A | VAL218 |
| A | GLN219 |
| A | GLY245 |
| A | HOH382 |
| A | HOH572 |
| A | HOH585 |
| A | HOH587 |
| A | HOH642 |
| A | HOH688 |
| A | HOH715 |
| A | HOH730 |
| B | GOL204 |
| B | SO4208 |
| B | HOH483 |
| B | HOH654 |
| B | HOH695 |
| B | HOH711 |
| A | HIS57 |
| A | ARG122 |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VTAGHC |
| Chain | Residue | Details |
| A | VAL53-CYS58 | |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. CMgrGDSGGSWI |
| Chain | Residue | Details |
| A | CYS189-ILE200 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | ACT_SITE: Charge relay system => ECO:0000250 |
| Chain | Residue | Details |
| A | HIS57 | |
| A | ASP102 | |
| A | SER195 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1ssx |
| Chain | Residue | Details |
| A | ASP102 | |
| A | SER195 | |
| A | GLY193 | |
| A | HIS57 | |
| A | SER214 | |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1ssx |
| Chain | Residue | Details |
| A | ASP102 | |
| A | SER195 | |
| A | GLY193 | |
| A | HIS57 | |
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 609 |
| Chain | Residue | Details |
| A | HIS57 | proton acceptor, proton donor |
| A | ASP102 | electrostatic stabiliser |
| A | GLY193 | electrostatic stabiliser |
| A | SER195 | electrostatic stabiliser |
| A | SER214 | electrostatic stabiliser |
